高精度测微计在车轴测量机上的应用方案

介绍了高精度测微计用于车轴直径测量的基本结构、关键技术及其在车轴测量设备上的应用。     

Strain Concentration Effect in Cu–Al–Ni Single Crystals under a Longitudinal Bending Force

The behavior of a superelastic Cu?14.2% Al?4%Ni single crystal in the case of high reversible strains under a longitudinal bending force was investigated. The effect of strain confinement along the crystal length was revealed and studied. The highest reversible strains (up to 10%) were shown to be confined within the central part of the bent crystal.     

Finishing Surface Treatment of Potassium Titanyl Phosphate Single Crystals by Argon Cluster Ions

Technical Physics Letters - It is demonstrated that a argon cluster ion beam can be used for the finishing treatment of ultrasmooth surfaces (with initial root-mean-square roughness below 0.3 nm)...     

Elp3 modulates neural crest and colorectal cancer migration requiring functional integrity of HAT and SAM domains

Cell migration is a finely tuned biological process that often involves epithelial-mesenchymal transition (EMT). EMT is typically characterized by the upregulation of mesenchymal markers such as Snail1. This process has been shown to be of critical importance to normal developmental processes, including neural crest migration and invasion. Interestingly, similar mechanisms are utilized in disease processes, such as tumor metastasis and migration. Notably, EMT and EMT-like processes confer tumor cells with the ability to migrate, invade, and adopt stem cell-like properties that largely account for immunosuppression and tumor recurrence. Therefore, identifying sensitive EMT markers may contribute to cancer prognosis and diagnosis in many facets. Previously, we showed that Elp3 plays an essential role during neural crest migration by stabilizing Snail1. In the current study, we further elucidate the molecular mechanism underlying colorectal cancer migration. We found that mElp3 exerted an identical function to xElp3 in modulating neural crest migration, and both HAT and SAM domains are imperative during this migratory process. Interestingly, overexpression of mElp3 in SW480 cells promoted cell migration and invasion, and we further showed that Elp3 stabilized Snail1 requiring integrity of both SAM and HAT domains. Our findings warrant further exploration of the specific target of Elp3 in cancer cells.     

Optimizing the Technology of Titanium Phosphate Adsorbent Synthesis from Sulfate-Containing Titanium(IV) Solutions

Theoretical Foundations of Chemical Engineering - An important state in the technology of a compositional silicon-containing titanium phosphate adsorbent is studied. The conditions of washing of...     

四氢姜黄素经PI3K/Akt信号通路对人血小板活化和聚集的调控作用

目的：探讨姜黄素的主要肠道代谢物四氢姜黄素（tetrahydrocurcumin，THC）对血小板活化和聚集的影响及其可能的分子机制。方法：在体外实验中，用不同浓度的THC（0、0.5、1、10 μmol/L）提前与健康人纯化血小板共同孵育40 min，然后加入凝血酶激活血小板2 min，用流式细胞术测定血小板表面CD62P和CD63的表达量，用酶联免疫吸附法测定血小板释放血小板因子-4（platelet factor-4，PF4）和趋化因子配体-5（chemokine ligand 5，CCL5）水平，用血小板聚集仪检测血小板释放ATP水平和血小板最大聚集率，用Western blot蛋白免疫印迹法检测血小板磷酸肌醇-3-激酶（phosphoinositide 3-kinase，PI3K）和Akt蛋白的磷酸化水平。结果：与模型组（血小板悬液中加入0.05%二甲基亚砜）相比，THC能抑制凝血酶诱导的血小板表面CD62P和CD63的表达，抑制PF4、CCL5和ATP的释放，降低血小板最大聚集率，下调PI3K和Akt蛋白的磷酸化水平，且呈浓度依赖效应，其中10 μmol/L的浓度下作用效果显著（P＜0.01、P＜0.001）。PI3K的特异性激动剂740 Y-P可部分逆转THC对PF4和CCL5释放和血小板聚集的抑制作用（P＜0.05、P＜0.01）。结论：THC具有显著抑制血小板活化和聚集的作用，其机制可能是THC可下调PI3K/Akt介导的信号通路。     

淡盐水脱氯的精细化控制

阐述了游离氯产生的原因及脱氯方法。介绍了新疆中泰化学(集团)股份有限公司华泰分公司通过对脱氯淡盐水pH值进行精细化控制,达到了降低成本、节能降耗的目的。     

温压补偿在CS3000中的应用

结合横河CS3000系统的使用情况,介绍了CS3000系统利用压力和温度检测点实现温度压力补偿功能,CS3000系统组态过程及功能块的运用等。     

采用微型桩加固塔吊基础的工程实践

天然地基承载力不能满足要求时,必须采用桩基加固塔吊基础。某高层建筑施工场地狭小,无法进行正常桩基础施工,采用微型桩加固塔吊地基处理仅用1d时间,经济效益良好,塔吊运行安全。     

水泥基材料热膨胀性能测试方法发展现状

综述国内外水泥基材料热膨胀性能测试方法的发展现状和各种测量方法的适用范围及特点。并以差示热膨胀法为例,详细介绍了硬化水泥基材料的热膨胀性能的测试原理、方法及测试结果。