Expression of Main Toll-Like Receptors in Patients with Different Types of Colorectal Polyps and Their Relationship with Gut Microbiota

Abnormal activation of Toll-like receptor (TLRs) signaling can result in colon cancer development. The aim of this study was to investigate the expression of important TLRs in different histological types of colorectal polyps and evaluate their relationship with intestinal microbiota. The expression levels of TLR2, 3, 4, and 5 were analyzed in intestinal biopsy specimens of 21 hyperplastic polyp (HP), 16 sessile serrated adenoma (SSA), 29 tubular adenoma (TA), 21 villous/tubulovillous (VP/TVP) cases, and 31 normal controls. In addition, selected gut bacteria including Streptococcus bovis, Enterococcus faecalis, Enterotoxigenic Bacteroides fragilis (ETBF), Fusobacterium nucleatum, Porphyromonas spp., Lactobacillus spp., Roseburia spp., and Bifidobacterium spp. were quantified in fecal samples using absolute qRT PCR, and, finally, the association between TLRs and these gut microbiota- was evaluated by Spearman’s correlation coefficient. Higher expression of TLR2 and TLR4 in VP/TVP and TA, and lower expression levels of TLR3 and TLR5 in all type of polyps were observed. The differences in TLR expression patterns was not only dependent on the histology, location, size, and dysplasia grade of polyps but also related to the intestinal microbiota patterns. TLR2 and TLR4 expression was directly associated with the F. nucleatum, E. faecalis, S. bovis, Porphyromonas, and inversely to Bifidobacterium, Lactobacillus, and Roseburia quantity. Furthermore, TLR3 and TLR5 expression was directly associated with Bifidobacterium, Roseburia, and Lactobacillus quantity. Our results suggest a possible critical role of TLRs during colorectal polyp progression. An abnormal regulation of TLRs in relation to gut microbial quantity may contribute to carcinogenesis.     

An experimental study of forced convective heat transfer for fully developed Al 2 O 3 –water nanofluid in an annulus tube

Nanofluids have been known as practical materials to ameliorate heat transfer within diverse industrial systems. The current work presents an empirical study on forced convection effects of Al₂O₃–water nanofluid within an annulus tube. A laminar flow regime has been considered to perform the experiment in high Reynolds number range using several concentrations of nanofluid. Also, the boundary conditions include a constant uniform heat flux applied on the outer shell and an adiabatic condition to the inner tube. Nanofluid particle is visualized with transmission electron microscopy to figure out the nanofluid particles. Additionally, the pressure drop is obtained by measuring the inlet and outlet pressure with respect to the ambient condition. The experimental results showed that adding nanoparticles to the base fluid will increase the heat transfer coefficient (HTC) and average Nusselt number. In addition, by increasing viscosity effects at maximum Reynolds number of 1140 and increasing nanofluid concentration from 1% to 4% (maximum performance at 4%), HTC increases by 18%.     

High Temperature Property Development of Bauxite Based Bricks

Physical properties and microstructural evolution on firing of 3 types of bauxite based refractory bricks were carried out using techniques such as porosimetry,XRD and SEM.The groups differed from each other by progressive refining of the matrix or bond phase.It is revealed that such a refinement of the matrix can improve the high temperature properties of the bricks made from poor grade materials.     

Energy-efficient video streaming over Bluetooth using rateless coding

Energy-efficient error control for IEEE 802.15.1 (Bluetooth) video communication is proposed. The scheme is based on block-oriented incremental redundancy provided by rateless coding and receiver feedback. Results are presented for time-sensitive video streaming applications under a Markovian channel model. When the proposed algorithm is compared to variations of Bluetooth forward error control, there are improvements of around 3 dB in received video quality and of over 10% in energy efficiency.     

Optimisation of enhancement layer DCT coefficients in MPEG-2 SNRscalable video

The authors describe an optimisation algorithm which can be applied to two-layer SNR scalable MPEG-2 video coding, such that bandwidth efficiency is achieved which is comparable to single-layer coding. Our optimised two-layer coder is shown to generate as little as 1% fewer bits than a single-layer coder compared to up to 15% more bits generated by the non-optimised SNR scalable coder     

An adapted H.261 two-layer video codec for ATM networks

An adaptive video codec which can maintain compatibility between the existing digital circuit switched networks and future ATM networks is described. It is based on two-layer coding principles, where in the base layer the H.261 standard video codec is employed. It is shown that a discrete cosine transform (DCT) in the second layer is unnecessary and can be replaced by a simple requantizer which finely quantizes the residue quantization distortions of the transform coefficients of the base layer. Characteristics of this quantizer in terms of nature of quantization and step sizes are studied. Efficient coding and addressing of residual distortions are described. Finally, a two-dimensional variable length code for the quantized residual distortions is given     

An incentive scheduling mechanism for peer-to-peer video streaming

P2P video streaming networks are found as a scalable solution and an alternative for traditional client–server based video streaming over the Internet. One of the significant issues affecting the success of any P2P streaming network is cooperation between peers. Practical observations have proved the prevalence of free riders in P2P networks that degrade their performance. To solve this problem, using incentive mechanisms, which encourage peers to contribute more in the network, is necessary. In this paper, we designed and proposed a distributed and scalable incentive mechanism for mesh based P2P video streaming networks. In the proposed approach the contribution of the peers is measured and maintained in a distributed fashion. Furthermore, we proposed an incentive sending side scheduler in which peers are served based on their contribution in the network. Our simulation evaluations show the efficiency of the proposed approach in improving the overall perceived video quality by the non-free rider nodes and consequently in the whole network.     

On the new solutions for a fully fuzzy linear system

In this paper, we propose a new method to present a fuzzy trapezoidal solution, namely “suitable solution”, for a fully fuzzy linear system (FFLS) based on solving two fully interval linear systems (FILSs) that are 1-cut and 0-cut of the related FILS. After some manipulations, two FILSs are transformed to 2n crisp linear equations and 4n crisp linear nonequations and n crisp nonlinear equations. Then, we propose a nonlinear programming problem (NLP) to computing simultaneous (synchronic) equations and nonequations. Moreover, we define two other new solutions namely, “fuzzy surrounding solution” and “fuzzy peripheral solution” for an FFLS. It is shown that the fuzzy surrounding solution is placed in a tolerable fuzzy solution set and the fuzzy peripheral solution is placed in a controllable fuzzy solution set. Finally, some numerical examples are given to illustrate the ability of the proposed methods.     

Mechanical and viscoelastic properties of polyethylene-based microfibrillated composites from 100% recycled resources

In this study, recycled polyethylene (rPE) based microfibrillated composites (MFCs) were developed while incorporating recycled poly(ethylene terephthalate) (rPET) and recycled polyamide 6 (rPA) as the reinforcing fibrillar phases at a given weight ratio of 80 wt% (rPE)/20 wt% (rPET or rPA). The blends were first melt processed using a twin-screw extruder. The extrudates were then cold stretched at a drawing ratio of 2.5 to form rPET and rPA fibrillar structures. Next, the pelletized drawn samples were injection molded at the barrel temperatures below the melting temperatures of rPET and rPA. The tensile, three-point bending, impact strength, dynamic thermomechanical, and rheological properties of the fabricated MFCs were analyzed. The effects of injection molding barrel temperature (i.e., 150°C and 190°C) and extrusion melt processing temperature (i.e., 250°C and 275°C) on the generated fibrillar structure and the resultant properties were explored. A strong correlation between the fibrillar morphology and the mechanical properties with the extrusion and injection molding temperatures was observed. Moreover, the ethylene/n-butyl acrylate/glycidyl methacrylate (EnBAGMA) terpolymer and maleic anhydride grafted PE (MAH-g-PE) were, respectively, melt processed with rPE/rPET and rPE/rPA6 blends as compatibilizers. The compatibilizers refined the fibrillar structure and remarkably influenced mechanical properties, specifically the impact strength.