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排序方式: 共有424条查询结果,搜索用时 31 毫秒
1.
Vancha Harish Effi Haque Magdalena
miech Hiroaki Taniguchi Sarah Jamieson Devesh Tewari Anupam Bishayee 《International journal of molecular sciences》2021,22(9)
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers. 相似文献
2.
D.V.N. Harish A. Bharatish H.N. Narasimha Murthy B. Anand K.N. Subramanya 《Ceramics International》2021,47(3):3498-3513
Laser ablation of high-temperature ceramic coatings results in thermal residual stresses due to which the coatings fail by cracking and debonding. Hence, the measurement of such residual stresses during laser ablation process holds utmost importance from the view of performance of coatings in extreme conditions. The present research aims at investigating the effect of laser parameters such as laser pulse energy, scanning speed and line spacing on thermal residual stresses induced in tantalum carbide-coated graphite substrates. Residual stresses were measured using micro-Raman spectroscopy and correlated with Raman peak shifts. Transient thermal analysis was performed using COMSOL Multiphysics to model the single ablated track and residual stresses were reported at low, moderate and high pulse energy regimes. The results showed that the initial laser conditions caused higher tensile residual stresses. Moderate pulse energy regime comprised higher compressive residual stresses due to off centre overlapping of the laser pulses. Higher pulse energy (250 μJ), higher scanning speed (1000 mm/s) and moderate line spacing (20 μm) caused accumulation of tensile residual stresses during the final stage of laser ablation. The deviation of experimental residual stresses from COMSOL numerical model was attributed to unaccounted additional stresses induced during thermal spraying process and deformation potentials in the numerical model. 相似文献
3.
Geerthana M. Ramachandran K. Harish S. Ramesh R. Selvaraj M. Navaneethan M. 《Journal of Materials Science: Materials in Electronics》2022,33(12):9204-9210
Journal of Materials Science: Materials in Electronics - Herein, we report the synthesis of three-dimensional (3D) and one-dimensional (1D) hierarchical hematite (α-Fe2O3) nanostructures on... 相似文献
4.
Mining high utility itemsets (HUIs) from transaction databases considers such factors as the unit profit and quantity of purchased items. Two-phase tree-based algorithms transform a database into compressed tree structures and generate candidate patterns through a recursive pattern-growth procedure. This procedure requires a lot of memory and time to construct conditional pattern trees. To address this issue, this study employs two compressed tree structures, namely, Utility Count Tree and String Utility Tree, to enumerate valid patterns and thus promote fast utility computation. Furthermore, the study presents an algorithm called single-phase utility computation (SPUC) that leverages these two tree structures to mine HUIs in a single phase by incorporating novel pruning strategies. Experiments conducted on both real and synthetic datasets demonstrate the superior performance of SPUC compared with IHUP, UP-Growth, and UP-Growth+ algorithms. 相似文献
5.
Yaseen K.R. Shariff Harish K. Choudhary Vijay Khopkar Ankit Yadav R. Madhusudhana Balaram Sahoo 《Ceramics International》2021,47(10):14907-14912
We report the mechanism involved in sol-gel auto-combustion synthesis of Ba–Sr-hexaferrite (Ba1-xSrxFe12O19; x = 0, 0.25, 0.5, 0.75 and 1, BSFO) ceramic powders through the analysis of the phases evolved during annealing of the as-synthesized powders, along with their structure and morphological studies. The XRD patterns of the as-synthesized samples indicate the formation of barium/strontium monoferrite ((Ba/Sr)Fe2O4) and maghemite (γ-Fe2O3) phases along with a minute amount of hematite (α-Fe2O3) phase. Annealing of these samples facilitates formation of BSFO phase through the solid state reaction between BaFe2O4 and γ-Fe2O3 phase. Interestingly, after annealing the samples with x = 0, 0.5 and 1, at 1000 °C for 2 h, we observed that phase pure Ba–Sr hexaferrite structure forms, but for samples with x = 0.25 and 0.75, high amount of hematite (α-Fe2O3) phase is observed, especially for x = 0.75. The reason associated with this could be the large difference between the ionic radii of Ba2+ and Sr2+ ions occupying the oxygen site. Furthermore, our study on annealing dependent phase evolution confirms that, this difference in ionic radii forbids the formation of a single phase Ba–Sr hexaferrite. The growth of clear hexagonal-shaped plate-like particles with varied particle sizes was observed for all the samples. The particle size variation may be due to the influence of the ionic radii difference on the sinterability of the samples. Our study provides a better understanding of synthesis mechanism of Ba–Sr hexaferrite samples. 相似文献
6.
Anala M. Reddy B.P. Harish 《International Journal of Circuit Theory and Applications》2020,48(5):739-749
The dominance of leakage currents in circuit design has been impelled by steady downscaling of MOSFET into nanometer regime, and has become a significant component of total IC power dissipation. The issue is further aggravated with the inability to gauge the tolerance of process parameters around their nominal value. Consequently, the drive to improve the static power prediction has enticed accurate and reliable modeling of leakage current, specifically for ultralow power applications. In contrast to gate- and band-to-band-tunneling leakages, subthreshold leakage exhibits high susceptibility to process variations and hence has been considered for variability modeling. Fluctuations in the device electrical and geometry parameters result in a wider distribution of subthreshold leakage current. Hence, taking into account stacking effect, an analytical variability model to estimate subthreshold leakage power in subthreshold circuits, in the presence of threshold voltage variations is proposed. Further, the impact of threshold voltage variability on subthreshold leakage power is modeled in conjunction with simultaneous variations in gate length and width. The leakage power variability is characterized by model-generated distributions obtained using Monte Carlo analysis and validated against SPICE simulations. The proposed model is about 700 computationally faster than SPICE simulations with mean error being less than 0.19%. 相似文献
7.
Shalini Gaur Rudra Sunita Singh Harish H. Haritha Bollinedi Kamalesh Narain Singh Lata Nain Surender Singh Om Prakash Awasthi 《International Journal of Food Science & Technology》2022,57(7):4566-4574
Grewia is a tropical berry rich in anthocyanins and antioxidants but highly perishable in nature. In this study, desirable composite blend of overripe Grewia (Phalsa) berries and cantaloupe was sought for conversion to acetic acid. Composition of raw macerate, and the alcoholic and acetic ferments was analysed for sugars, alcohol and acetic acid. The primary alcohol yield varied significantly (5.75–99.44%) with blend composition. Vinegar from select blend attained 4.98% acidity with 138.57 mg mL−1 of phenols and high anthocyanins retention (74.77%). Gompertz model was used to fit the growth curves of S. cerevisiae and A. aceti (R2> 0.92) during fermentation. Presence of ethyl acetate, iso-pentyl alcohols explained pleasant sweet fruity aroma of resulting vinegar. Thus, high quality functional red fruit vinegar can be obtained to prevent spoilage and utilise the functional potential of this delicate and nutritious berry. 相似文献
8.
Simon Patrick D. Bharathi P. Krishna Mohan M. Muthamizchelvan C. Harish S. Navaneethan M. 《Journal of Materials Science: Materials in Electronics》2022,33(12):9235-9245
Journal of Materials Science: Materials in Electronics - Layered transition metal dichalcogenide (TMD) materials possess novel and unique semiconducting properties when exfoliated into thin sheets... 相似文献
9.
Santhi K. Harish S. Navaneethan M. Ponnusamy S. 《Journal of Materials Science: Materials in Electronics》2022,33(12):9066-9084
Journal of Materials Science: Materials in Electronics - In the recent years, metal oxides have attracted more interest for researchers because of their applications in energy and... 相似文献
10.
Harish C. Upadhyay Dr. Gaurav R. Dwivedi Dr. Sudeep Roy Dr. Ashok Sharma Mahendra P. Darokar Dr. Santosh K. Srivastava 《ChemMedChem》2014,9(8):1860-1868
Phytol was chemically transformed into fifteen semi‐synthetic derivatives, which were evaluated for their antibacterial and drug resistance reversal potential in combination with nalidixic acid against E. coli strains CA8000 and DH5α. The pivaloyl ( 4 ), 3,4,5‐trimethoxybenzoyl ( 9 ), 2,3‐dichlorobenzoyl ( 10 ), cinnamoyl ( 11 ), and aldehyde ( 14 ) derivatives of phytol ((2E,7R,11R)‐3,7,11,15‐tetramethyl‐2‐hexadecen‐1‐ol) were evaluated by using another antibiotic, tetracycline, against the MDREC‐KG4 clinical isolate of E. coli. Derivative 4 decreased the maximal inhibitory concentration (MIC) of the antibiotics by 16‐fold, while derivatives 9 , 10 , 11 , and 14 reduced MIC values of the antibiotics up to eightfold against the E. coli strains. Derivatives 4 , 9 , 10 , 11 , and 14 inhibited the ATP‐dependent efflux pump; this was also supported by their in silico binding affinity and down‐regulation of the efflux pump gene yojI, which encodes the multidrug ATP‐binding cassette transporter protein. This study supports the possible use of phytol derivatives in the development of cost‐effective antibacterial combinations. 相似文献