Direct Growth of Germanene at Interfaces between Van der Waals Materials and Ag(111)

Germanene, a 2D honeycomb germanium crystal, is grown at graphene/Ag(111) and hexagonal boron nitride (h-BN)/Ag(111) interfaces by segregating germanium atoms. A simple annealing process in N₂ or H₂/Ar at ambient pressure leads to the formation of germanene, indicating that an ultrahigh-vacuum condition is not necessary. The grown germanene is stable in air and uniform over the entire area covered with a van der Waals (vdW) material. As an important finding, it is necessary to use a vdW material as a cap layer for the present germanene growth method since the use of an Al₂O₃ cap layer results in no germanene formation. The present study also proves that Raman spectroscopy in air is a powerful tool for characterizing germanene at the interfaces, which is concluded by multiple analyses including first-principles density functional theory calculations. The direct growth of h-BN-capped germanene on Ag(111), which is demonstrated in the present study, is considered to be a promising technique for the fabrication of future germanene-based electronic devices.     

Defining Dry Eye from a Clinical Perspective

Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED etiology. Although many definitions of DED have been used, discrepancies exist between the various definitions of dry eye disease (DED) used across the globe. This article presents a clinical consensus on the definition of DED, as formulated in four meetings with global DED experts. The proposed new definition is as follows: “Dry eye is a multifactorial disease characterized by a persistently unstable and/or deficient tear film (TF) causing discomfort and/or visual impairment, accompanied by variable degrees of ocular surface epitheliopathy, inflammation and neurosensory abnormalities.” The key criteria for the diagnosis of DED are unstable TF, inflammation, ocular discomfort and visual impairment. This definition also recommends the assessment of ocular surface epitheliopathy and neurosensory abnormalities in each patient with suspected DED. It is easily applicable in clinical practice and should help practitioners diagnose DED consistently. This consensus definition of DED should also help to guide research and clinical trials that, to date, have been hampered by the lack of an established surrogate endpoint.     

Investigation of hydrogen plasma treatment for reducing defects in silicon quantum dot superlattice structure with amorphous silicon carbide matrix

We investigate the effects of hydrogen plasma treatment (HPT) on the properties of silicon quantum dot superlattice films. Hydrogen introduced in the films efficiently passivates silicon and carbon dangling bonds at a treatment temperature of approximately 400°C. The total dangling bond density decreases from 1.1 × 10¹⁹ cm^-3 to 3.7 × 10¹⁷ cm^-3, which is comparable to the defect density of typical hydrogenated amorphous silicon carbide films. A damaged layer is found to form on the surface by HPT; this layer can be easily removed by reactive ion etching.     

Silicon quantum dot superlattice solar cell structure including silicon nanocrystals in a photogeneration layer

The solar cell structure of n-type poly-silicon/5-nm-diameter silicon nanocrystals embedded in an amorphous silicon oxycarbide matrix (30 layers)/p-type hydrogenated amorphous silicon/Al electrode was fabricated on a quartz substrate. An open-circuit voltage and a fill factor of 518 mV and 0.51 in the solar cell were obtained, respectively. The absorption edge of the solar cell was 1.49 eV, which corresponds to the optical bandgap of the silicon nanocrystal materials, suggesting that it is possible to fabricate the solar cells with silicon nanocrystal materials, whose bandgaps are wider than that of crystalline silicon.

PACS

85.35.Be; 84.60.Jt; 78.67.Bf     

哈尔滨近代建筑的形态母题及美学意匠1、2

本文从形态学的角度通过对哈尔滨近代建筑顶部形态（屋顶突出物和女儿墙）的细部构成的归纳、抽象，概括出其母题的基本类型；并根据统计结果，得出具有普遍性的形态母题。通过对整体关系的抽象，概括出其模式的基本类型；并根据统计结果，得出具有普遍性的关系模式；在上述定量分析的基础上，结合美学原理，对其所蕴含的美学意匠作了分析。     

Capability of Utilizing CYP3A5 Polymorphisms to Predict Therapeutic Dosage of Tacrolimus at Early Stage Post-Renal Transplantation

While CYP3A5 polymorphisms are used to predict the initial dosage of tacrolimus therapy, the predictive capability of genetic information for dosing at early stage post-renal transplantation is unknown. We investigated the influence of polymorphisms over time. An initial oral dose of modified-release once-daily tacrolimus formulation (0.20 mg/kg) was administered to 50 Japanese renal transplant patients every 24 h. Stepwise multiple linear regression analysis for tacrolimus dosing was performed each week to determine the effect of patient clinical characteristics. The dose-adjusted trough concentration was approximately 70% higher for patients with the CYP3A5*3/*3 than patients with the CYP3A5*1 allele before the second pre-transplantation tacrolimus dose (0.97 (0.78–1.17) vs. 0.59 (0.45–0.87) ng/mL/mg; p < 0.001). The contribution of genetic factors (CYP3A5*1 or *3) for tacrolimus dosing showed increased variation from Day 14 to Day 28 after transplantation: 7.2%, 18.4% and 19.5% on Days 14, 21 and 28, respectively. The influence of CYP3A5 polymorphisms on the tacrolimus maintenance dosage became evident after Day 14 post-transplantation, although the tacrolimus dosage was determined based only on patient body weight for the first three days after surgery. Tacrolimus dosage starting with the initial administration should be individualized using the CYP3A5 genotype information.     

Sensitivity of charged particle activation analysis for long-lived radioactive nuclide determination

ABSTRACT

Charged Particle Activation Analysis (CPAA) utilizing an 8-MeV proton beam has been studied for determination of 35 long-lived radioactive nuclides. We accumulated the reaction cross section and nuclear decay data by referring to nuclear database supplied by National Nuclear Data Center in Brookhaven National Laboratory. We also calculated the reaction cross sections by using statistical model code ALICE. By using the nuclear data, we have derived determination sensitivity of the radioactive nuclides relative to unit weight and specific radioactivity. The result indicates that several hardly measurable nuclides with long half-lives such as ¹³⁵Cs, ²⁴⁴Pu, ¹²⁹I, ¹²⁶Sn, ⁹³Mo, ¹⁰⁷Pd, ²³⁶U, ²⁴⁸Cm, and ²³⁷Np have high sensitivity. It may be concluded that CPAA can be applied to determination of several long-lived nuclei and will provide a quick and non-destructive analysis method.     

Adaptive set‐point regulation of discrete‐time nonlinear systems

In this paper, adaptive set‐point regulation controllers for discrete‐time nonlinear systems are constructed. The system to be controlled is assumed to have a parametric uncertainty, and an excitation signal is used in order to obtain the parameter estimate. The proposed controller belongs to the category of indirect adaptive controllers, and its construction is based on the policy of calculating the control input rather than that of obtaining a control law. The proposed method solves the adaptive set‐point regulation problem under the assumption that the target state is reachable for each fixed parameter value. Additional feature of the proposed method is that Lyapunov‐like functions have not been used in the construction of the controllers. Copyright © 2015 John Wiley & Sons, Ltd.     

Experimental investigation on optimization of invert trap configuration for sewer solid management

Invert traps have been successfully used to collect sediments at convenient locations within the sewer network, where large volumes of solids can be stored. In the present study, experiments have been performed in 15 cm wide and 5 m long channel for the measurement of retention ratios of five different invert trap configurations (namely, rectangular, trapezoidal with one side vertical, trapezoidal, trapezoidal with rectangular base, rectangular with trapezoidal base) having top width of 32 cm and depth of 28 cm with slots of three different sizes (namely, 5, 9 and 15 cm) for the flow of seven different sediment types (namely, two types of sand, glass beads and four types of plastic beads) at different flow rates for each trap. The flow rates selected in present study cover entire range of flow rate expected in channels during dry weather flow and monsoon. Flow field and retention ratio predictions for each invert trap configuration have been carried out using CFD modeling with the help of FLUENT software using Renormalization Group (RNG) k–ε along with Discrete Phase Model (DPM). The simulation results are capable of showing particle trajectories, the effect of flow rate and trap geometry on the flow patterns, developed within the trap. Based on CFD modeling and experimental measurements, it is concluded that the invert trap having rectangular shape with trapezoidal base is the most efficient trap configuration with highest sediment retention ratio.