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排序方式: 共有822条查询结果,搜索用时 31 毫秒
1.
Matthew Thomas Ferreira Juliano Andreoli Miyake Renata Nascimento Gomes Fbio Feitoza Pollyana Bulgarelli Stevannato Andrew Silva da Cunha Fernanda de Oliveira Serachi Alexandros Theodoros Panagopoulos Alison Colquhoun 《International journal of molecular sciences》2021,22(9)
Prostaglandin E2 (PGE2) is known to increase glioblastoma (GBM) cell proliferation and migration while cyclooxygenase (COX) inhibition decreases proliferation and migration. The present study investigated the effects of COX inhibitors and PGE2 receptor antagonists on GBM cell biology. Cells were grown with inhibitors and dose response, viable cell counting, flow cytometry, cell migration, gene expression, Western blotting, and gelatin zymography studies were performed. The stimulatory effects of PGE2 and the inhibitory effects of ibuprofen (IBP) were confirmed in GBM cells. The EP2 and EP4 receptors were identified as important mediators of the actions of PGE2 in GBM cells. The concomitant inhibition of EP2 and EP4 caused a significant decrease in cell migration which was not reverted by exogenous PGE2. In T98G cells exogenous PGE2 increased latent MMP2 gelatinolytic activity. The inhibition of COX1 or COX2 caused significant alterations in MMP2 expression and gelatinolytic activity in GBM cells. These findings provide further evidence for the importance of PGE2 signalling through the EP2 and the EP4 receptor in the control of GBM cell biology. They also support the hypothesis that a relationship exists between COX1 and MMP2 in GBM cells which merits further investigation as a novel therapeutic target for drug development. 相似文献
2.
Journal of Signal Processing Systems - 相似文献
3.
Alexandros Papadopoulos Issaak Parcharidis Panagiotis Elias Pierre Briole 《International journal of remote sensing》2019,40(16):6365-6382
We analysed the ground deformation across two blocks defined by the Rio-Patras fault from 1993 to 2017 using multi-temporal Synthetic Aperture Radar Interferometry (InSAR) techniques. Our main objective was to contribute to the assessment of seismic hazard near the large city of Patras. Multiple data-sets were used, each one covering different temporal periods. Descending and ascending acquisitions, providing different viewing geometries contribute to fully determine the ground displacement in 3D. The data-sets used are from the European Space Agency’s (ESA) European Remote Sensing (ERS), Environmental Satellite (ENVISAT) and SENTINEL-1 as well as German Aerospace Center (DLR) ’s TERRASAR-X missions. Considering ESA’s missions covering both acquisition geometries and long periods, the southern block, showing lack of a sufficient number of scatterers does not allow the displacement characterization. In contrary, the northern block is characterized by a high number of scatterers having values of maximum likehood ranging from ?3.5 to ?4.3 mm year?1 for ascending geometry and from ?1.6 to ?2.7 mm year?1 for the descending one. The fact that both geometries show negative values of displacements are consistent with downlift movement and at the same time the quantitative differentiation probably indicates an horizontal component as well. 相似文献
4.
Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
5.
Panayiotis M. Papadopoulos Vasso Reppa Marios M. Polycarpou Christos G. Panayiotou 《IEEE/CAA Journal of Automatica Sinica》2020,7(3):638-655
The enormous energy use of the building sector and the requirements for indoor living quality that aim to improve occupants’ productivity and health, prioritize Smart Buildings as an emerging technology. The Heating, Ventilation and Air-Conditioning (HVAC) system is considered one of the most critical and essential parts in buildings since it consumes the largest amount of energy and is responsible for humans comfort. Due to the intermittent operation of HVAC systems, faults are more likely to occur, possibly increasing eventually building’s energy consumption and/or downgrading indoor living quality. The complexity and large scale nature of HVAC systems complicate the diagnosis of faults in a centralized framework. This paper presents a distributed intelligent fault diagnosis algorithm for detecting and isolating multiple sensor faults in large-scale HVAC systems. Modeling the HVAC system as a network of interconnected subsystems allows the design of a set of distributed sensor fault diagnosis agents capable of isolating multiple sensor faults by applying a combinatorial decision logic and diagnostic reasoning. The performance of the proposed method is investigated with respect to robustness, fault detectability and scalability. Simulations are used to illustrate the effectiveness of the proposed method in the presence of multiple sensor faults applied to a 83-zone HVAC system and to evaluate the sensitivity of the method with respect to sensor noise variance. 相似文献
6.
Suitability,efficiency and microbiological safety of novel physical technologies for the processing of ready‐to‐eat meals,meats and pumpable products 下载免费PDF全文
Alexandros Ch. Stratakos Anastasios Koidis 《International Journal of Food Science & Technology》2015,50(6):1283-1302
Consumer studies and market reports show an increase in consumption of ready‐to‐eat (RTE) foods. Although conventional processing technologies can in most cases produce safe products, they can also lead to the degradation of nutritional compounds and negatively affect quality characteristics. Consumers strongly prefer food that is minimally processed with the maximum amount of health‐promoting substances. Novel processing technologies as pre‐ or post‐treatment decontamination methods or as substitutes of conventional technologies have the potential to produce foods that are safe, rich in nutrient content and with superior organoleptic properties. Combining novel with conventional processes can eliminate potential drawbacks of novel technologies. This review examines available scientific information and critically evaluates the suitability and efficiency of various novel thermal and nonthermal technologies in terms of microbial safety, quality as well as nutrient content on the production of RTE meals, meats and pumpable products. 相似文献
7.
Chousainov Iskanter-Alexandros Moscholios Ioannis Kaloxylos Alexandros Logothetis Michael 《Wireless Networks》2020,26(6):3953-3965
Wireless Networks - In this paper we consider a cloud radio access network (C-RAN) where the remote radio heads (RRHs) are separated from the baseband signal processing servers, named baseband... 相似文献
8.
Alexandros G. Venetsanos 《International Journal of Hydrogen Energy》2018,43(50):22715-22726
The estimation of the release conditions is critical input to subsequent risk assessment accident analysis. To this respect a new homogeneous non-equilibrium two-phase model is proposed to simulate the depressurization from stagnation conditions leading to the bubbly flow regime. The proposed model, being intermediate between HEM (homogeneous equilibrium) and HFM (homogeneous frozen) models, presents no discontinuity in the liquid phase depressurization path gradient and therefore no discontinuity in sound speed. The proposed model is successfully validated against the NASA hydrogen critical flow experiments and compared against predictions from both HEM and HFM, using hydrogen physical properties from NIST. An increase of the pressure difference between stagnation and the intersection of isentropic with saturation line leads to increase of the choked mass flux, decrease of the throat to stagnation pressure ratio, decrease of the liquid superheat and decrease of the vapor quality. The proposed model was found to overestimate the experimental throat mass fluxes by no more than 10% and underestimate the experimental throat to stagnation pressure ratios by no more than 50%, while predicted liquid superheat values range from 3.8 to 11% of the saturation temperature. Deviations between models were found to increase for low values of the pressure difference parameter, where non-equilibrium effects become more important. Under these conditions the throat mass flux is underestimated by maximum 20% by HEM and overestimated up to 32% by HFM, while the throat to stagnation pressure ratio is overestimated by up to 72% and underestimated by 80% respectively. 相似文献
9.
10.
Theodoros A. Papadopoulos Hong Li Eung-Gun Kim Jie Liu James A. Cella Christian M. Heller Andrew Shu Antoine Kahn Anil Duggal Jean-Luc Brédas 《Israel journal of chemistry》2014,54(5-6):779-788
At metal/organic interfaces, the insertion of an organic monolayer can significantly modify the surface properties of the substrate, especially in terms of charge injection across the interface. Herein, we study the formation of an insulating monolayer of morpholine or amine-functionalized polystyrene on Al(111) and Au(111) surfaces and its impact on surface work-function and charge injection. First-principles calculations based on Density Functional Theory have been carried out and point to a significant decrease in the work-function of modified metal surfaces; this is in very good agreement with ultraviolet photoemission spectroscopy measurements performed on the Au(111) surface. In addition, a bilayer cathode, consisting of a thin film of high-work-function metal, such as Al and Au, and a layer of amine-functionalized polystyrene, was also fabricated and tested in organic light-emitting diodes. Such bilayer structures exhibit substantially enhanced efficiency when compared with controls without the functionalized polymers. Our combined theoretical and experimental investigation gives insight into how a thin layer of a commodity polymer can be used to transform rather high-work-function metals into high-performance cathodes to provide efficient electron injection. 相似文献