The tangent stiffness matrix for an absolute interface coordinates floating frame of reference formulation

Multibody System Dynamics - In this work, a full and complete development of the tangent stiffness matrix is presented, suitable for the use in an absolute interface coordinates floating frame of...     

Peripheral and central adrenoceptor modulation of the behavioural effects of clozapine in the paw test

1. In rats, the atypical neuroleptic, clozapine, has been found to increase the hindlimb retraction time but not the forelimb retraction time, in the paw test. These parameters have predictive validity for the antipsychotic efficacy and extrapyramidal side-effects of drugs, respectively. The present study analysed to what extent drugs acting on adrenoceptors affect the behavioural effect of clozapine in the paw test. 2. The alpha 1-adrenoceptor agonist, ST 587 but not the peripherally working alpha 1-agonist, methoxamine, decreased the effect of clozapine on the hindlimb retraction time. The alpha 1-antagonist phenoxybenzamine increased this effect of clozapine, and blocked the effect of ST 587 on clozapine at low doses. Only the combination of phenoxybenzamine with clozapine produced an increase in forelimb retraction time. 3. The alpha 2-adrenoceptor agonist, clonidine, decreased the effect of clozapine on the hindlimb retraction time. This effect was neither antagonized by the alpha 2-antagonist rauwolscine nor by the alpha 1-antagonist phenoxybenzamine. Rauwolscine or the peripherally working alpha 2-antagonist L-659,066 did not influence the effect of clozapine on the hindlimb retraction time. The forelimb retraction time was not affected by any of the drug combinations. 4. In contrast to the beta 2-adrenoceptor agonist, clenbuterol, which was ineffective, the peripherally acting beta-agonist, (-)-isoprenaline, increased the effects of clozapine on the hindlimb retraction time. The beta-antagonist, (-)-propranolol as well as the peripherally acting beta-antagonist, nadolol decreased this effect of clozapine. Low doses of the peripherally acting beta 1-antagonist, atenolol, as well as low doses of the beta2-antagonist, ICI-118,551, decreased the effect of clozapine. A low dose of nadolol blocked the effect of (-)-isoprenaline on clozapine. Only the combination of clenbuterol with clozapine produced an increase in forelimb retraction time.5. It is concluded that blockade of central alpha l-adrenoceptors plays an important role in the effect of clozapine on the hindlimb retraction time. Furthermore, the effect of clozapine on the hindlimb retraction time is strongly modulated by peripheral beta 1- and/or beta 2-adrenoceptors. Given the predictive validity of the paw test, the presented data suggest that the alpha 1-adrenoceptor antagonist properties of clozapine are important for its therapeutic effects, but not for its lack of extrapyramidal side-effects.     

Dynamic substructuring and reanalysis methods in a surrogate-based design optimization environment

In light weight structure design, vibration control is necessary to meet strict stability requirements and to improve the fatigue life of structural components. Due to ever-increasing demands on products, it is generally more convenient to include vibration prerequisites in a design process instead of using vibration control devices on fixed designs. One of the main difficulties associated to design optimization of complex and/or large structures is the numerous computationally demanding Finite Element (FE) calculations. The objective of this research is to present a novel strategy for efficient and accurate optimization of vibration characteristics of structures. In the proposed strategy, a sub-structuring method is utilized. The FE model of the complete structure is partitioned, reduced and then reassembled. This increases the computational efficiency of dynamic analyses. Moreover, this method is coupled with a novel reanalysis technique to speed up the repeated structural analyses. These methods are finally embedded in a surrogate-based design optimization procedure. An academic test problem is used for the validation of this novel approach.     

Updating the Craig–Bampton reduction basis for efficient structural reanalysis

A Combined Approximation (CA) based reanalysis technique is proposed for updating the static modes in a reduction basis which can be used for sizing optimization problems. Although the proposed technique is utilized under the framework of the Craig–Bampton (CB) method, it can be employed with any condensation procedure that involves the computation of the static modes. An automated update scheme is also presented that switches the proposed technique with the exact analysis when the computational efficiency is lost. Moreover, the Enriched Craig–Bampton (ECB) method is studied for the reanalysis of the normal modes. The ECB‐ and the CA‐based techniques are merged for efficient update of the CB reduction basis. An academic test problem is utilized for the demonstration of the introduced concepts. Copyright © 2010 John Wiley & Sons, Ltd.     

An optimization method for dynamics of structures with repetitive component patterns

The design obtained from a topology optimization problem can be sensitive to the type and details of the ground structure used. A new type of ground structure containing hinged beam elements is described that increases the types of elements in the ground structure available to the optimizer. In addition to the pin-ended truss and rigidly-connected beam elements that have traditionally been used, two new types of elements are introduced: (1) a beam with a hinge on one end and a solid connection on the other end, (2) a beam with hinges on both ends. These elements have different deflection characteristics than those of the typical truss or beam elements, and can be used in ground structure-based compliant mechanism design. Given a reduced ground structure, these new elements effectively increase the design space. Pin-ended members with lengths larger than those of the ground structure cell size are permitted to develop, reducing the sensitivity of solutions to the cell density of the reduced ground structure. Furthermore, because these longer members do not require intermediate lateral support to provide stability, as series connections of shorter pin-ended members do, fewer ancillary members are required. Two compliant mechanism problems are solved to demonstrate the effectiveness of these new elements.