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Fatemighomi Hamideh Sadat Golalizadeh Mousa Amani Meisam 《Pattern Analysis & Applications》2022,25(2):467-481
Pattern Analysis and Applications - Efficient high-dimensional analyses of hyperspectral datasets and their utilization within classification algorithms is a popular topic in the field of data... 相似文献
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Marziyeh Hayati Ghasem Rezanejade Bardajee Majid Ramezani Samaneh Sadat Hosseini Farhang Mizani 《Polymer International》2020,69(2):156-164
Hydrogels, nanogels and nanocomposites show increasing potential for application in drug delivery systems due to their good chemical and physical properties. Therefore, we were encouraged to combine them to produce a new compound with unique properties for a long‐term drug release system. In this regard, the design and application of a nanocomposite hydrogel containing entrapped nanogel for drug delivery are demonstrated. To this aim, we first prepared an iron oxide nanocomposite nanogel based on poly(N‐isopropylacrylamide)‐co‐((2‐dimethylaminoethyl) methacrylate) (PNIPAM‐co‐PDMA) grafted onto sodium alginate (NaAlg) as a biocompatible polymer and iron oxide nanoparticles (ION) as nanometric base (PND/ION‐NG). This was then added into a solution of PDMA grafted onto NaAlg. Through dropwise addition of mixed aqueous solution of iron salts into the prepared polymeric solution, a novel hydrogel nanocomposite with excellent pH, thermal and magnetic responsivity was fabricated. The synthesized samples were fully characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy with energy‐dispersive X‐ray analysis, vibrating sample magnetometry and atomic force microscopy. A mechanism for the formation of PNIPAM‐co‐PDMA/NaAlg‐ION nanogel–PDMA/NaAlg‐ION hydrogel and PND/ION nanogel is suggested. Swelling capacity was measured at various temperatures (25 to 45 °C), pH values (from 2 to 11) and magnetic field and under load (0.3 psi) and the dependence of swelling properties of the nanogel–hydrogel nanocomposite on these factors was well demonstrated. The release rate of doxorubicin hydrochloride (DOX) as an anticancer drug was studied at different pH values and temperatures in the presence and absence of a magnetic field. The results showed that these factors have a high impact on drug release from this nanocomposite. The result showed that DOX release could be sustained for up to 12.5 days from these nanocomposite hydrogels, significantly longer than that achievable using the constituent hydrogel or nanogel alone (<1 day). The results indicated that the nanogel–hydrogel nanocomposite can serve as a novel nanocarrier for anticancer drug delivery. © 2019 Society of Chemical Industry 相似文献
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Saadatmand Faezeh Sadat Rohbani Nezam Baharvand Farshad Farbeh Hamed 《The Journal of supercomputing》2021,77(2):1939-1957
The Journal of Supercomputing - Technology scaling has exacerbated the aging impact on the performance and reliability of integrated circuits. By entering into nanotechnology era in recent years,... 相似文献
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Shi Yuyuan Taylor Lindsey Waterton Cheung Vien Sayem Abu Sadat Muhammad 《Applied Composite Materials》2022,29(1):159-171
Applied Composite Materials - Current sports bras are typically manufactured via a cut and sew process resulting in a high volume of post-production material waste. Seams derived from this cut and... 相似文献