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排序方式: 共有567条查询结果,搜索用时 15 毫秒
1.
Rajiv K. Bedi Dr. Danzhi Huang Stefanie A. Eberle Dr. Lars Wiedmer Dr. Pawel Śledź Prof. Amedeo Caflisch 《ChemMedChem》2020,15(9):744-748
The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to the N6 atom of adenine. We have screened a library of 4000 analogues and derivatives of the adenosine moiety of SAM by high-throughput docking into METTL3. Two series of adenine derivatives were identified in silico, and the binding mode of six of the predicted inhibitors was validated by protein crystallography. Two compounds, one for each series, show good ligand efficiency. We propose a route for their further development into potent and selective inhibitors of METTL3. 相似文献
2.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite numerous efforts to target epidermal growth factor receptor (EGFR), commonly dysregulated in GBM, approaches directed against EGFR have not achieved the same degree of success as seen in other tumor types, particularly as compared to non-small cell lung cancer (NSCLC). EGFR alterations in glioblastoma lie primarily in the extracellular domain, unlike the kinase domain alterations seen in NSCLC. Small molecule inhibitors are difficult to develop for the extracellular domain. Monoclonal antibodies can be developed to target the extracellular domain but must contend with the blood brain barrier (BBB). We review the role of EGFR in GBM, the history of trialed treatments, and the potential paths forward to target the pathway that may have greater success. 相似文献
3.
Multimedia Tools and Applications - In high speed railways, the intelligent railway safety system is necessary to avoid the accidents due to collision between trains and obstacles on the railway... 相似文献
4.
This paper analyses the experimental results, obtained in a compartment fire experiment [Kumar R. Studies on compartment fires. Ph.D. thesis. Indian Institute of Technology, Roorkee, 2004], by using CFD modelling. Experiments were conducted in a compartment by burning methanol as a fuel. Temperatures vs. time were recorded at 11 different locations in the compartment for three sizes of fires. 相似文献
5.
One way of overcoming the problem of false alarms encountered in a single parameter detection system due to non-fire stimulii is the simultaneous use of multiple signatures. Researchers have found significant benefits of multi-sensor detection in reducing false triggering. Appreciable interest has been expressed in using carbon monoxide (CO) or carbon dioxide (CO2) gas sensors in combination with smoke sensors. The present study has been carried out to determine the correlation and inter-dependence between two different fire signatures like CO–OD (optical density), CO–CO2, CO2–OD. The signatures have been investigated using experimental measurements of a fire inside a closed compartment measuring 7 x 7 x 4.2 m. A range of fuels are used, and both smouldering and flaming combustion are examined. Attempts have been made to examine whether correlation coefficients between two signatures can form a basis of detection and be exploited as one of the components in multi- criteria fire detection algorithm. The CO/CO2 ratio as a criterion for detector operation has also been examined and discussed in the light of existing literature and codal provisions. 相似文献
6.
This paper presents the effect of open dumping of municipal solid waste (MSW) on soil characteristics in the mountainous region of Himachal Pradesh, India. The solid waste of dumpsite contains various complex characteristics with organic fractions of the highest proportions. As leachate percolates into the soil, it migrates contaminants into the soil and affects soil stability and strength. The study includes the geotechnical investigation of dump soil characteristics and its comparison with the natural soil samples taken from outside the proximity of dumpsites. The geochemical analysis of dumpsite soil samples was also carried out by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). Visual inspection revealed that the MSW consists of high fraction of organics, followed by paper. The soil samples were collected from five trial pits in the dumpsites at depths of 0.5 m, 1 m and 1.5 m. Then the collected soil samples were subjected to specific gravity test, grain size analysis, Atterberg's limit test, compaction test, direct shear test, California bearing ratio (CBR) test and permeability analysis. The study indicated that the dumpsite soils from four study regions show decreasing trends in the values of maximum dry density (MDD), specific gravity, cohesion and CBR, and increasing permeability as compared to the natural soil. The results show that the geotechnical properties of the soils at all four study locations have been severely hampered due to contamination induced by open dumping of waste. 相似文献
7.
Pal Shaili Kumar Ajay Kumar Sunil De Arup Kumar Prakash Rajiv Sinha Indrajit 《Catalysis Letters》2022,152(11):3259-3271
Catalysis Letters - Magnetically recyclable visible light photocatalysts for the degradation of critical organic pollutants are an urgent industrial requirement. Nonetheless, one component... 相似文献
8.
9.
Singh Siddharth Rathore Vivek Singh Singh Rajiv Singh Manoj Kumar 《Multimedia Tools and Applications》2017,76(18):19113-19137
Multimedia Tools and Applications - Image watermarking in wavelet domain has been found useful for copyright protection and rightful ownership. Classical wavelet transforms, like discrete wavelet... 相似文献
10.
Praveen Siluvai Antony Rajiv Ananth Sohony Rajesh B. Biniwale 《International Journal of Hydrogen Energy》2014
A mathematical model has been developed to study the impact of nozzle-catalyst distance and bulk gas temperature on the conversion and hydrogen evolution rate in a spray pulse reactor. The effects of reactor configuration and operating parameters on conversion and evolution rate were predicted with more than 90% accuracy. Reactor optimization and sensitivity analysis were carried out and an optimal design of nozzle-catalyst distance 5 cm and bulk gas temperature of 50 °C were proposed. The optimized design was predicted to increase the conversion from approximately 32–74%. The model could be in general used for designing any endothermic heterogeneous catalytic reaction in a spray pulse reactor. 相似文献