The bioconversion of tunisian phosphorite usingAspergillus niger

It is well known that the production of phosphoric fertilizers by traditional methods is connected with certain environmental problems, particularly related to use of acids during the decomposition of natural phosphates. A basic problem is also the fact that only 15 – 20% of the phosphorus contained in superphosphates is assimilated by plants.The development of methods to process natural phosphates without acid precipitation has potential advantages and in this respect biotechnological processing of natural phosphates in order to obtain organo-mineral fertilizers is very promising. The possibility of bioconverting the phosphorus of natural phosphates by usingAspergillus niger fungi through their deep incubation has been investigated. The investigations aim to achieve a high degree of P₂O₅ extraction from the phosphates with conversion from a non-utilizable to a utilizable form. The influence of the fungal strain, the kind of nutritive medium and the time of incubation of the process of biological mobilization of the phosphate rock is examined.It was established that the time of incubation, the kind of micro-organisms of theAspergillus niger group, as well as the kind of nutritive medium, influence significantly the process of bioconversion and the conversion of phosphorus from non-utilizable to water-soluble and utilizable for plants form. A maximum degree 90% of phosphorus extraction in the form of water-soluble and citrate-soluble has been reached for 10-day incubation. Physicochemical examinations have been carried out and they have proved that, as a result of the produced organic acids, a process of decomposition of the initial Tunisian phosphorite takes place.     

膜分离技术在制药工业中的应用

膜分离技术在制药工业中的应用包括生物发酵制药、中药生产和现代生物技术等．膜分离技术在抗生素、半合成抗生素、维生素和氨基酸生产中尤其常见．随着膜材料、膜组件和膜设备的不断改进，膜分离技术在制药工业中将扮演越来越重要角色．     

新型功能高分子材料及其应用

功能高分子是一类具有特殊用途的高分子材料 ,印迹高分子、敏感性水凝胶和固定化酶是三种较有特色的功能高分子材料。该文将对上述三种功能高分子材料以及它们在生化分离、生物催化、物质分析与检测以及药物控制释放中的应用做一介绍 ,同时也对它们的不足和发展前景进行了评述     

生物工程及其在化学工业中的应用

生物工程是近年来崛起的一门综合性的高新科学技术，也是当代新技术革命中最为活跃的领域。文章简要地介绍和评述了生物工程的主要内容及其在化学工业中应用的概况及发展趋势。     

生物化工

从生物化工的形成、研究内容、研究现状与展望等方面介绍了生物化工。     

Alternative technologies for biotechnological fuel ethanol manufacturing

The challenges of implementing biorefineries on a global scale include socioeconomic, financial, and technological constraints. In particular, the development of biorefineries is tightly linked to the continued availability of fermentation raw materials. These constraints can be relaxed by the use of diverse raw materials, while advances that confer higher flexibility would enable biotechnological plant managers to swiftly react to volatile markets. In conventional processes, Saccharomyces cerevisiae grows on a relatively limited range of substrates, and produces only a single product—ethanol. Given the observed maturity of the S. cerevisiae fermentation technology, alternatives to baker's yeast may be needed to tip the economic balance in favour of biotechnological ethanol. These alternative fermentation technologies may allow a greater diversity of substrates to be used to produce an individually tailored mix of ethanol and other chemicals. Copyright © 2007 Society of Chemical Industry     

Acidolysis of babassu fat catalyzed by immobilized lipase

The lipase-catalyzed interesterification of oils and fats gives products that are unobtainable by chemical interesterification methods. Acidolysis of babassu fat and palmitic acid, catalyzed by immobilized lipase (Lipozyme; Novo Industri, Bagsveard, Denmark), was studied. The reactions were performed at 65°C with 5% w/w enzyme for 4 h. The molar proportions of babassu fat/palmitic acid were 1∶0.1, 1∶0.3 and 1∶0.5. At the end of the reaction period, the catalyst particles were removed by filtration, and the residual oil was extracted with organic solvent (diethyl ether). The recovered particles were then reused. The palmitic acid content of babassu fat before and after acidolysis changed from 10 to 22% at a molar proportion of 1∶0.5. The equilibrium was attained in about 4 h. The original water and enzymatic activities of Lipozyme were maintained after acidolysis. Water sorption isotherms of the immobilized enzyme were determined at 25, 35 and 45°C. From the temperature dependence of the isotherms, isosteric heats of sorption were evaluated by means of the Clausius Clapeyron equation. Monolayer moisture content was calculated by means of the B.E.T. and Guggenhein-Anderson-De Boer analyses. Paper presented at the International Meeting on Fats and Oils Technology, Universidade Estadual de Campinas, Brazil, 1991.     

From IP to Start-up： Building a Robust Life Science Incubator

An incubator is an organization that supports new ventures to grow and survive during the early stages. Mainly dedicated to information technology, life science may appear to be the next hot spot for incubators. Are there stabilized good practices？ Are the business models in information technology and in life science comparable when it goes to start-ups＇ incubation？ Leveraging our experience as practitioner in this field and using an inductive methodology, this paper tends to propose simple principles to help build robust incubators in life science, and to contribute to disseminate an entrepreneurial approach through an industry still dominated by blue chips.     

生物技术生产纤维素酶及其应用研究进展

简要介绍纤维素酶的酶学性质、降解机制、生产工程菌的选育、纤维素酶的应用情况,以及对纤维素酶生产与应用方面存在的问题和未来发展趋势进行了分析与探讨。纤维素酶在食品、酿造行业、农副产品深加工、饲料、医药、环境保护和化工等领域有着非常广阔的应用前景和应用潜力。我国纤维素酶的生产及应用研究近年来取得了很大进展,今后必将在应用深度和广度上进一步扩展。