Designing amorphous formulations of polyphenols with naringin by spray-drying for enhanced solubility and permeability

Naringin (NAR), a major flavanone (FVA) glycoside, is a component of food mainly obtained from grapefruit. We used NAR as a food additive to improve the solubility and permeability of hydrophobic polyphenols used as supplements in the food industry. The spray-dried particles (SDPs) of NAR alone show an amorphous state with a glass transition temperature (T_g) at 93.2 °C. SDPs of hydrophobic polyphenols, such as flavone (FVO), quercetin (QCT), naringenin (NRG), and resveratrol (RVT) were prepared by adding varying amounts of NAR. All SDPs of hydrophobic polyphenols with added NAR were in an amorphous state with a single T_g, but SDPs of hydrophobic polyphenols without added NAR showed diffraction peaks derived from each crystal. The SDPs with NAR could keep an amorphous state after storage at a high humidity condition for one month, except for SDPs of RVT/NAR. SDPs with NAR enhanced the solubility of hydrophobic polyphenols, especially NRG solubility, which was enhanced more than 9 times compared to NRG crystal. The enhanced solubility resulted in the increased membrane permeability of NRG. The antioxidant effect of the hydrophobic NRG was also enhanced by the synergetic effect of NAR. The findings demonstrated that NAR could be used as a food additive to enhance the solubility and membrane permeability of hydrophobic polyphenols.     

新型高k栅介质材料研究进展

随着半导体技术的不断发展，MOSFET（metal-oxide-semiconductor field effect transistor）的特征尺寸不断缩小，栅介质等效氧化物厚度已小至nm数量级。这时电子的直接隧穿效应将非常显著，将严重影响器件的稳定性和可靠性。因此需要寻找新型高k介质材料，能够在保持和增大栅极电容的同时，使介质层仍保持足够的物理厚度来限制隧穿效应的影响。本文综述了研究高k栅介质材料的意义；MOS栅介质的要求；主要新型高k栅介质材料的最新研究动态；展望了高k介质材料今后发展的主要趋势和需要解决的问题。     

种分Δαk与种分首槽αk的关系

针对烧结法和拜尔法种分槽的 Δαk 变化进行了概述 ,阐述了种分 Δαk 与种分首槽 αk 的关系。     

棒束临界热流密度流体模化研究

在空泡物理和自然循环重点实验室氟里昂热工实验装置上进行了CHF实验 ,实验段为9 5×1 0mm元件管组成的 4× 4棒束 ,并对其开展了 4× 4棒束CHF流体模化研究。在压力 1 5 9～ 2 73MPa、质量流速 4 88～ 2 0 80kg (m2 ·s)、临界含汽率 -0 2 0～ 0 3 0的工况范围内 ,采集了 1 70个 4× 4棒束CHF实验数据 ,并与压力 9 9～ 1 6 2MPa、质量流速 2 74～ 1 4 73kg (m2 ·s)、临界含汽率 -0 2 0～0 3 4工况范围内 ,以水为工质相同棒束实验段内的 2 0 6个棒束CHF实验数据进行比较 ,发现Ahmad补偿失真模型、张振杰模型和Stevens Kirby模型在上述工况范围内不再适用于棒束CHF的模化 ,这些模型的预测偏差均大于 2 0 %以上 ,而且棒束CHF模化的流量模化因子k明显地受压力、质量流量和入口含汽率的影响。据此提出适用于上述工况范围内 4× 4棒束CHF模化的流量模化因子k的关系式 ,其CHF预测偏差在± 1 5 %以内 ,均方根误差为 7 0 5 %。     

Barrier layer effect of tantalum on the electromigration in sputtered copper films on hydrogen silsesguioxane and SiO2

As IC devices scale down to the submicron level, the resistance-capacitance (RC) time delays are the limitation to circuit speed. A solution is to use low dielectric constant materials and low resistivity materials. In this work, the influence of underlying barrier Ta on the electromigration (EM) of Cu on hydrogen silsesquioxane (HSQ) and SiO₂ substrates was investigated. The presence of a Ta barrier not only improves the adhesion between Cu and dielectrics, but also enhances the crystallinity of Cu film and improves the Cu electromigration resistance. The activation energy obtained suggests a grain boundary migration mechanism and the current exponent calculated indicates the Joule heating effect.     

不含4圈的最大简单图边数的下界

证明了具有不小于6个顶点的不包含4圈的简单图的最大可能边数的下界是2n-5。     

一种智能卡口令认证方案的分析与改进

袁,吕提出了一种智能卡口令认证方案.在他们的方案中,用户能随意更改口令,远程系统不需要存储用户的口令表或验证表,并能防止重放攻击.作者指出袁-吕方案不能抵抗假冒攻击,并进行了改进.     

Consequences of the formation of Cooper-pairs near oxygen-deficient sites

In this investigation we consider the formation of Cooper pairs near the oxygen-deficient sites in Y-Ba-Cu-O ceramic superconductors which would give rise to an energy-dependent potential as seen by conduction charge carriers. It is shown that Cooper pairs could be formed under such conditions, resulting in a supercurrent. We use the Bogoliubov transformation technique to calculate the energy gap, the energy difference, and the transition temperature of the model superconductor using certain data obtained from previous experiments. Numerical analysis shows that the superconducting current can be explained by the presence of such oscillating Cooper pairs.     

Persistence of nonprotein seed amino acid s-(β-carboxyethyl)-cysteine in young leaves ofCalliandra rubescens Ecological implications

The insecticidal nonprotein amino acid S-(-carboxyethyl)-cysteine (S-CEC) is the major free amino acid in the seeds of severalCalliandra spp. where it accounts for up to 2.9 % of dry weight. Lesser amounts of other related S-containing amino acids and an array of nonprotein imino acids derived from pipecolic acid are other constituents. High concentrations of imino acids, which also show insecticidal activity, are maintained in the mature leaves, but sulfur compounds are lacking. In this study the disappearance of S-CEC from the germinating seeds and young seedlings ofC. rubescens was monitored over time. After 10 weeks, S-CEC continues to be found in high concentrations in the stems and new leaves. As young leaves mature, sulfur compounds quickly decrease in concentration. Traces of S-CEC are found in new leaves of plants up to nine months after germination. Whether high concentration of S-CEC in young leaves is due to transportation from the seed or de novo synthesis is unclear. The ecological implications are discussed.     

无线传感器网络不确定数据PT-Top k查询处理技术

在无线传感器网络现实应用中,感知数据普遍存在不确定性。由于不确定数据引入了概率维度,使得不确定数据查询种类更加丰富,同时也给查询处理带来困难。不确定数据Top-k查询是一个典型的不确定数据查询任务。考虑到无线传感器网络查询处理技术对查询响应时间和网络通信消耗的高要求,研究了面向层次聚簇结构的无线传感器网络不确定数据Top-k查询处理技术。通过分析不确定数据特点,基于x-tuple规则元组模型,采用簇内与簇间的两阶段数据查询处理机制,提出了基于Poisson分布的分布式不确定数据PT-Top k查询处理近似算法TPQP。通过实验,从总体通信消耗、与概率阈值p相关分析、与排序数k相关分析以及数据敏感度分析等方面,说明了TPQP算法在通信消耗、查询响应时间上的优越性。