AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression

The extracellular matrix (ECM) is important for normal development and disease states, including inflammation and fibrosis. To understand the complex regulation of ECM, we performed a suppressor screening using Caenorhabditis elegans expressing the mutant ROL-6 collagen protein. One cuticle mutant has a mutation in dpy-23 that encodes the μ2 adaptin (AP2M1) of clathrin-associated protein complex II (AP-2). The subsequent suppressor screening for dpy-23 revealed the lon-2 mutation. LON-2 functions to regulate body size through negative regulation of the tumor growth factor-beta (TGF-β) signaling pathway responsible for ECM production. RNA-seq analysis showed a dominant change in the expression of collagen genes and cuticle components. We noted an increase in the cav-1 gene encoding caveolin-1, which functions in clathrin-independent endocytosis. By knockdown of cav-1, the reduced TGF-β signal was significantly restored in the dpy-23 mutant. In conclusion, the dpy-23 mutation upregulated cav-1 expression in the hypodermis, and increased CAV-1 resulted in a decrease of TβRI. Finally, the reduction of collagen expression including rol-6 by the reduced TGF-β signal influenced the cuticle formation of the dpy-23 mutant. These findings could help us to understand the complex process of ECM regulation in organism development and disease conditions.     

AP1000稳压器波动管竖直管段空气-水CCFL实验研究

使用竖直管代替波动管模型开展稳压器波动管竖直管段内空气-水两相逆流限制（CCFL）特性可视化实验研究。实验现象表明:竖直管与上容器接口处的局部CCFL决定了进入竖直管内的液相流量；竖直管内的局部CCFL决定了从竖直管流出的液相流量；两处局部CCFL均随空气流量的增大而增强。在较低气量情况，进入竖直管内的液相能够完全或大部分流出，竖直管内的局部CCFL较弱，上容器和竖直管接口处的局部CCFL在整体CCFL中占主导地位，整体CCFL程度随着上容器液位升高而略有增强。在高气量情况，从上容器进入竖直管的液相大部分或者完全被限制而不能向下流出，竖直管内的局部CCFL强烈，在整体CCFL中占主导地位，整体CCFL特性不受上容器液位变化的影响。通过实验数据拟合得到了新的稳压器竖直管CCFL模型。稳压器波动管CCFL数据和稳压器竖直管CCFL数据基本重合，表明波动管CCFL主要由CCFL-U决定。      

A self-adaptive weighted affinity propagation clustering for key frames extraction on human action recognition

In this paper, we propose a novel approach for key frames extraction on human action recognition from 3D video sequences. To represent human actions, an Energy Feature (EF), combining kinetic energy and potential energy, is extracted from 3D video sequences. A Self-adaptive Weighted Affinity Propagation (SWAP) algorithm is then proposed to extract the key frames. Finally, we employ SVM to recognize human actions on the EFs of selected key frames. The experiments show the information including whole action course can be effectively extracted by our method, and we obtain good recognition performance without losing classification accuracy. Moreover, the recognition speed is greatly improved.     

Coastal trapped waves in the southern Caspian Sea

Previous studies reported coastal trapped waves (CTWs) in the Caspian Sea (CS). This study deals with the generation mechanisms, the temporal and spatial variability of CTWs in this area, and their transformations during propagation from the origin to the destination using recent measurements and high-resolution numerical simulations. CTWs are observed at all stations with periods of 2–6 days after northerly storms. The Absheron Peninsula, old Sefidrud delta, and Nur coasts were identified as the CTWs prone regions. The generation of CTWs in these locations was confirmed using numerical experiments. The propagation away from the generating location of CTWs was analyzed using a representative real wind storm. In the west part of the CS, the generation mechanism of CTWs is mainly similar to the barotropic Kelvin waves; in contrast, it is similar to the continental shelf waves in the southern shelves. The results can be used to study the contribution of generated CTWs to the transport of sediment and biological materials in all large lakes.     

预控法与均值极差图在磷铵生产中的应用

以磷铵生产工艺指标中和料浆中N与P物质的量比为例,对比分析了预控法与均值极差图应用效果差异,发现在标准偏差较小的数据分析时,应用预控法效果更佳。     

超临界水氧化工艺降低高氯酸铵废水中氨氮浓度的试验

通过建立超临界水氧化试验装置,采用超临界技术对固体推进剂生产废水进行处理,研究了含高氯酸铵废水NH3N去除率与氧气流量、废水流量、反应釜温度和压力的关系。结果表明最佳的超临界水氧化条件：温度为390～410℃、压力为22MPa、控制氧气流量为0．6～1．0L/min、废水流量为2L/h,NH3N去除率可达99％,处理后NH3N浓度低于3mg/L,达到了国家排放标准。     

基于STEP的异型螺杆数控加工技术

为了适应异型螺杆集成制造技术的发展趋势,研究了螺旋面的STEP数据模型和内旋风铣削技术,提出一种基于STEP的异型螺杆数控加工方法。研究了螺旋面的STEP数据模型和几何信息的提取方法;给出了利用非均匀有理B样条模型获取螺旋面参数的方法;研究了螺旋面的内旋风包络铣削加工工艺及其刀轨计算方法;针对异型螺杆设计了一种计算机辅助制造系统,该系统包括STEP文件读取分析、特征识别、刀轨计算、刀轨验证、后处理等模块,实现了异型螺杆的设计系统与数控加工系统之间的有效集成。该系统的主要功能已实现并在实际加工中获得了验证。     

纳米CuCr_2O_4的制备及其对AP热分解性能的影响

采用HLG-5型纳米化粉碎机制备了粒径约为60nm的纳米CuCr2O4,用X射线衍射仪(XRD)、透射电子显微镜(TEM)表征了样品的结构及形貌,分析了纳米CuCr2O4的形成机理,用差示扫描量热仪(DSC)研究了原料CuCr2O4和纳米CuCr2O4对AP热分解性能的影响。结果表明,与原料CuCr2O4相比,质量分数2%的纳米CuCr2O4对AP具有更好的催化性能,可使AP的低温分解峰减弱,高温分解峰温降低67℃,反应速率常数提高数倍,使AP的表观分解热从821J/g提高到1 393J/g,增长率为69.7%。     

含AP炸药装药在剪切加载下的动态响应特性

采用小落锤加载装置和自行设计的剪切装置研究了含AP及不含AP的两种炸药装药在剪切加载下的动态响应特性,分别采用高速摄影和扫描电镜记录了装药动态响应过程和晶体的微观状态。结果表明,含AP炸药装药的临界点火阈值为1.0m,不含AP炸药装药的临界点火阈值为1.2m,表明AP的加入使整个炸药装药变得敏感;炸药药柱在加载作用下主要经历冲击、塑性流动、剪切、飞散、反应等阶段;剪切加载后的AP晶体损伤以剪切变形和穿晶断裂为主,而RDX晶体以塑性变形和破碎为主,差异主要与AP晶体的力学强度较低及没有明确的熔点性能有关。     

AP1000核电厂二回路主管道双端断裂流体喷射力计算分析

AP1000是先进的第三代压水堆核电厂,为确保核电厂在事故工况下的安全性,需对二回路主管道发生双端断裂的工况进行研究。本文采用RELAP5/MOD3.4软件对核电厂二回路突发主管道双端断裂的事故工况进行了数值模拟,计算得到断裂后管道破口处的喷放流量、压强、空泡份额及喷射力等物理参数的变化特性,并将计算结果与ANSI 58.2简化计算方法的结果进行了比较分析。结果表明,RELAP5/MOD3.4计算所得的喷射力小于简化计算方法所得结果。本文分析结果为进行AP1000核电厂的破裂管道甩击防护提供了基础。