| 阿司匹林-壳聚糖缓释微球的制备和释药性能研究 |
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| 引用本文： | 周莉,吴奕光,罗仲宽,刘波,廖传东,张念.阿司匹林-壳聚糖缓释微球的制备和释药性能研究[J].广东化工,2010,37(2):197-199. |
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| 作者姓名： | 周莉 吴奕光 罗仲宽 刘波 廖传东 张念 |
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| 作者单位： | 深圳大学,化学与化工学院,深圳市功能高分子重点实验室,广东,深圳,518060 |
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| 摘 要： | 采用乳化交联法制备阿司匹林-壳聚糖缓释凝胶微球,通过透析实验检测微球的体外释放特性。应用正交实验设计,考察了壳聚糖浓度,搅拌速度,阿司匹林/壳聚糖质量比,交联时间对微球制备的影响。体外释放实验表明,壳聚糖微球前5个小时的释放符合SRP的释药行为。以5个小时的体外释放总量为指标进行直观分析,交联时间对5小时的体外释放总量影响最大。
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| 关 键 词： | 阿司匹林 壳聚糖 缓释微球 乳化交联法 |
Preparation and Controlled Release Characteristic of Aspirin-loaded Chitosan Microspheres |
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| Zhou Li,Wu Yiguang,Luo Zhonkuang,Liu Bo,Liao Chuandong,Zhang Nian.Preparation and Controlled Release Characteristic of Aspirin-loaded Chitosan Microspheres[J].Guangdong Chemical Industry,2010,37(2):197-199. |
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| Authors: | Zhou Li Wu Yiguang Luo Zhonkuang Liu Bo Liao Chuandong Zhang Nian |
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| Affiliation: | College of Chemistry and Chemical Engineering;Shenzhen University;Shenzhen Key Laboratory of Functional polymer;Shenzhen 518060;China |
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| Abstract: | The preparation technique of aspirin-loaded chitosan microspheres and its release characteristic was investigated.Aspirin-loaded chitosan sustained-release gel microspheres were prepared via emulsion cross-linking technology.Dialysis method was used to determine the releasing characteristic of microspheres in vitro.The orthogonal experimental design was applied to review the preparation procedure by influence of chitosan concentration,stirred rate,mass ratio of aspirin/chitosan and emulsion cross-linking ti... |
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| Keywords: | aspirin chitosan sustained-release microspheres emulsion cross-linking technology |
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