银杏叶提取物的猴头菌转化产物降血糖作用的研究

对比研究了银杏叶提取物（EGB）、猴头菌转化EGB的产物、猴头菌发酵液、猴头菌发酵液中添加EGB以及二甲双胍等对四氧嘧啶诱导的糖尿病模型小鼠血糖水平的影响。将四氧嘧啶诱导的糖尿病模型小鼠分组给样，考察各组样品对各组小鼠的血糖、血咐、果糖胺（FA）以及超氧化歧化酶（SOD）水平等指标的影响。结果表明：相对于其他组别，猴头菌转化银杏叶提取物的转化产物能显著降低糖尿病模型小鼠的血脂、血糖和FA水平，能有效提高SOD酶活和增加模型小鼠的体重。表明猴头菌转化银杏叶提取物的转化产物的降血糖能力得到了明显提高。本项研究为寻求新的中药防治糖尿病的方法，改善和提高中药药效具有参考价值。

Hypoglycemic Effect of the Transformation Products from the Extract of Ginkgo biloba Leaf by Hericium erinaceus

The blood glucose effects of various treatments, such as Ginkgo biloba leaf extract (EGB), biotransformation products of EGB by Hericium erinaceus, supernatant of submerged culture of H.erinaceus, the supernatant combined with EGB, and the control groups were compared in alloxan-induced hyperglycemic mice. The levels of blood glucose, lipid, fructosamine, and SOD activity in the model mice were measured after different treatments using samples above. Results showed that the biotransformation products of EGB by H.erinaceus, comparing with other groups, significantly reduced the levels of blood glucose, fructosamine, and increased the serum SOD activity and the body weights of the alloxan-induced mice. The results indicated that the blood glucose decreasing by biotransformation products of EGB was remarkably improved. Our investigations also provided useful information and references for screening the new herb products to control the diabetes and improving the effects of the herbs.