Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-β/Smad Signaling Pathway

Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl₄)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl₄-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway.     

基于全U网络的混凝土路面裂缝检测算法

针对现有的混凝土裂缝检测算法在各种复杂环境中检测精度不够、鲁棒性不强的问题,根据深度学习理论和U-net模型,提出一种全U型网络的裂缝检测算法。首先,依照原U-net模型路线构建网络;然后,在每个池化层后都进行一次上采样,恢复其在池化层之前的特征图规格,并将其与池化之前的卷积层进行融合,将融合之后的特征图作为新的融合层与原U-net网络上采样之后的网络层进行融合;最后,为了验证算法的有效性,在测试集中进行实验。结果表明,所提算法的平均精确率可达到83.48%,召回率为85.08%,F1为84.11%,相较于原U-net分别提升了1.48%,4.68%和3.29%,在复杂环境中也能提取完整裂缝,保证了裂缝检测的鲁棒性。     

金针菇多糖对微冻大黄鱼及其鱼片品质变化的影响

为研究金针菇多糖（polysaccharide from Flammulina velutipes，FVP）对微冻大黄鱼及鱼片在贮藏期间肌原纤维蛋白性质的变化及水分分布的影响，实验分别选用0.03、0.06、0.09 g/L FVP浸渍处理大黄鱼和鱼片，以无菌水处理为对照组，分析微冻贮藏期间样品的感官指标得分、总挥发性盐基氮含量、总巯基含量、Ca2＋-ATPase活性、蛋白流变学性质以及水分迁移变化规律。结果表明：FVP可有效抑制整鱼总挥发性盐基氮含量上升和感官得分的下降；减缓整鱼及鱼片在微冻过程中总巯基含量、Ca2＋-ATPase活性下降和水分流失；此外FVP还能够延缓大黄鱼因腐败而出现的蛋白凝胶能力减弱。在本实验选取的多糖浓度范围内，0.09 g/L FVP处理组保鲜效果较强。该研究结果可为FVP用于水产品贮运保鲜提供理论参考。     

反坦克导弹用热电池研究进展

反坦克导弹作为击毁坦克和其他装甲目标的武器装备,在国家安全领域具有重要地位.热电池作为反坦克导弹的能源系统,对导弹功能实现具有重要意义.围绕反坦克导弹用热电池快激活和瞬时高比功率技术,结合热电池电化学材料体系发展历史、现状,探讨了提升快激活能力,提高瞬时比功率输出能力的技术,并对技术发展趋势进行了展望.     

Strong tribocatalytic dye degradation by tungsten bronze Ba4Nd2Fe2Nb8O30

The triboelectric effect has recently demonstrated its great potential in environmental remediation and even new energy applications for triggering a number of catalytic reactions by utilizing trivial mechanical energy. In this study, Ba₄Nd₂Fe₂Nb₈O₃₀ (BNFN) submicron powders were used to degrade organic dyes via the tribocatalytic effect. Under the frictional excitation of three PTFE stirring rods in a 5 mg/L RhB dye solution, BNFN demonstrates a high tribocatalytic degradation efficiency of 97% in 2 h. Hydroxyl radicals (?OH) and superoxide radicals (?O₂－) were also detected during the catalysis process, which proves that triboelectric energy stimulates BNFN to generate electron-hole pairs. The tribocatalysis of tungsten bronze BNFN submicron powders provides a novel and efficient method for the degradation of wastewater dye by utilizing trivial mechanical energy.     

黄淮平原“环城湖”景观的空间发展与生成机制研究 — —以淮阳为例

地缘环境造就了不同城市景观的独 特性。环城湖就是受黄河泛滥影响，河流中下 游平原产生的特殊城市景观。但在发展过程 中，这些城市出现了不同程度的水域面积缩减 的现象，城市风景的独特性也随之消失。淮阳 作为此类环城湖景观保存较为完好的城市， 环城湖的发展历程具有很强的代表性，研究 环城湖的生成机制能为保护和发展城市整体 格局提供明晰的理论支撑。论文在史料研究 基础上，梳理了淮阳的城市景观发展特征以 及此特征下城湖空间格局的形成过程；整理了 在地势低下、极端降雨、河泛频繁、政治经济 转移影响下的淮阳环城湖的形成机制，以期为 淮阳城市的发展研究提供参考与借鉴。     

Effects of (Li0.5Sm0.5)/W co-substitution and sintering temperature on the structure and electrical properties of ultrahigh Curie temperature piezoceramics,Ca0.92(Li0.5Sm0.5)0.08Bi2Nb2-xWxO9

With co-substitution of (Li_0.5Sm_0.5) at A site and W at B site, the electrical properties of modified Ca_0.92(Li_0.5Sm_0.5)_0.08Bi₂Nb_2-xW_xO₉ [(CLS)BN-xW, x = 0, 0.015 and 0.03] piezoceramics with ultrahigh Curie temperature (T_C) of > 930 °C were enhanced dramatically. The increased resistivity induced by the co-substitution ensure them to be polarized under an enough high field. Combined with the increase of spontaneous ferroelectric polarization (P_S), the significant enhancements in the piezoelectric, dielectric and ferroelectric properties can be obtained in the composition x = 0.015. Furthermore, the piezoelectric activity (d₃₃) and bulk resistivity (ρ_b) of (CLS)BN-0.015 W can be further enhanced at an appropriate sintering temperature. This optimum composition sintered at 1170 °C shows ultrahigh T_C of ～948 °C, d₃₃ of ～17.3 pC/N and ρ_b of ～6.9 MΩ cm at 600 °C, which are comparable to those of the reported high-temperature Aurivillius piezoceramics with T_C > 850 °C.     

美国网络空间领域战略思想及发展重点研究

美军将网络空间视为继陆、海、空、天外的第五大作战域,并将其列为国防部11项现代化优先事项之一,在美国等军事大国推动下,网络空间成为国家安全竞争和军事斗争的新疆域.文中对近年美国联邦政府、各部门及各军种发布的网络空间领域主要战略政策、规划计划进行梳理,研究其主要战略思想;分析美军2022财年国防预算、研究经费投向投量及重点项目的 研发情况.形成的研究成果将对我国网络空间安全领域研究提供技术支撑.     

基于图神经网络的网络性能智能预测

传统网络性能预测技术存在网络状态获取不够全面及网络性能评估准确性欠佳等问题，利用图神经网络学习推理网络关系数据的特点，结合捕获的网络全局信息，提出了一种基于图神经网络的网络性能智能预测方法。通过网络系统抽象及网络性能建模，将复杂的网络信息转化为形式化的图数据进行描述，利用图空域卷积处理图网络节点的消息传递过程，实现网络信息之间的关系推理，研究了实现网络性能预测的图神经网络模型，提出了一种能处理流量矩阵、网络拓扑、路由策略、节点配置的图神经网络体系结构，最后通过实验论证了模型能更好地实现包括时延、抖动和丢包率的网络性能的准确预测。