| 吴景,陈骁鹏,袁华峰,曹进,钱忠义,邢书霞.清咽类保健食品中非法添加盐酸二氧丙嗪的 检测方法研究[J].食品安全质量检测学报,2014,5(9):2663-2669 |
| 清咽类保健食品中非法添加盐酸二氧丙嗪的 检测方法研究 |
| Determination of dioxopromethazine hydrochloride illegally adulteration in health care food |
| 投稿时间：2014-07-24 修订日期：2014-09-15 |
| DOI： |
| 中文关键词: 保健食品 盐酸二氧丙嗪 非法添加 高效液相色谱法 超高效液相-飞行时间质谱联用法 |
| 英文关键词:health food dioxopromethazine hydrochloride illegally adulteration high performance liquid chromatography ultra performance liquid chromatography-quadrupole time of flight mass spectrometry |
| 基金项目:中国食品药品检定研究院中青年发展研究基金项目(2013NC6) |
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| 中文摘要: |
| 目的 建立对保健食品中非法添加的盐酸二氧丙嗪的筛查方法。方法 采用薄层色谱法(TLC)进行快速筛查, 采用高效液相色谱法(HPLC)对盐酸二氧丙嗪进行定性分析以及定量测定, 并采用超高效液相-质谱联用法(UPLC-MS)进行确证。结果 薄层色谱法盐酸二氧丙嗪斑点显色明显; 高效液相色谱法在11.149?222.977 μg/mL范围内线性良好, 质谱图中盐酸二氧丙嗪分子离子峰及二级碎片离子明显。 结论 本方法专属性强, 灵敏度高, 重现性好, 可作为清咽类保健食品是否添加盐酸二氧丙嗪的检测方法。 |
| 英文摘要: |
| Objective To establish a method for identification of dioxopromethazine hydrochloride illegally added in health care food. Methods The dioxopromethazine hydrochloride was identified by thin layer chromatography (TLC) and ultra performance liquid chromatography quadrupole time of flight mass spectrometry(UPLC-QTOF-MS), and the content was determined by high performance liquid chro-matography (HPLC). Results The linear range of the method was between 11.149 and 222.977 μg/mL, and the regression equation was Y=4.8870×104X+8.6351×103 with correlation coefficient of 0.9999. The detection limit was 1.115 μg/mL. Conclusion The method is convenient, reliable and accurate. It can be used to detect illegal adulteration of dioxopromethazine hydrochloride in health care food. |
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