Designing amorphous formulations of polyphenols with naringin by spray-drying for enhanced solubility and permeability

Naringin (NAR), a major flavanone (FVA) glycoside, is a component of food mainly obtained from grapefruit. We used NAR as a food additive to improve the solubility and permeability of hydrophobic polyphenols used as supplements in the food industry. The spray-dried particles (SDPs) of NAR alone show an amorphous state with a glass transition temperature (T_g) at 93.2 °C. SDPs of hydrophobic polyphenols, such as flavone (FVO), quercetin (QCT), naringenin (NRG), and resveratrol (RVT) were prepared by adding varying amounts of NAR. All SDPs of hydrophobic polyphenols with added NAR were in an amorphous state with a single T_g, but SDPs of hydrophobic polyphenols without added NAR showed diffraction peaks derived from each crystal. The SDPs with NAR could keep an amorphous state after storage at a high humidity condition for one month, except for SDPs of RVT/NAR. SDPs with NAR enhanced the solubility of hydrophobic polyphenols, especially NRG solubility, which was enhanced more than 9 times compared to NRG crystal. The enhanced solubility resulted in the increased membrane permeability of NRG. The antioxidant effect of the hydrophobic NRG was also enhanced by the synergetic effect of NAR. The findings demonstrated that NAR could be used as a food additive to enhance the solubility and membrane permeability of hydrophobic polyphenols.     

新型高k栅介质材料研究进展

随着半导体技术的不断发展，MOSFET（metal-oxide-semiconductor field effect transistor）的特征尺寸不断缩小，栅介质等效氧化物厚度已小至nm数量级。这时电子的直接隧穿效应将非常显著，将严重影响器件的稳定性和可靠性。因此需要寻找新型高k介质材料，能够在保持和增大栅极电容的同时，使介质层仍保持足够的物理厚度来限制隧穿效应的影响。本文综述了研究高k栅介质材料的意义；MOS栅介质的要求；主要新型高k栅介质材料的最新研究动态；展望了高k介质材料今后发展的主要趋势和需要解决的问题。     

Bootstrapping the Local Periodogram of Locally Stationary Processes

Abstract. Locally stationary processes are non‐stationary stochastic processes the second‐order structure of which varies smoothly over time. In this paper, we develop a method to bootstrap the local periodogram of a locally stationary process. Our method generates pseudo local periodogram ordinates by combining a parametric time and non‐parametric frequency domain bootstrap approach. We first fit locally a time varying autoregressive model so as to capture the essential characteristics of the underlying process. A locally calculated non‐parametric correction in the frequency domain is then used so as to improve upon the locally parametric autoregressive fit. As an application, we investigate theoretically the asymptotic properties of the bootstrap method proposed applied to the class of local spectral means, local ratio statistics and local spectral density estimators. Some simulations demonstrate the ability of our method to give accurate estimates of the quantities of interest in finite sample situations and an application to a real‐life data‐set is presented.     

种分Δαk与种分首槽αk的关系

针对烧结法和拜尔法种分槽的 Δαk 变化进行了概述 ,阐述了种分 Δαk 与种分首槽 αk 的关系。     

棒束临界热流密度流体模化研究

在空泡物理和自然循环重点实验室氟里昂热工实验装置上进行了CHF实验 ,实验段为9 5×1 0mm元件管组成的 4× 4棒束 ,并对其开展了 4× 4棒束CHF流体模化研究。在压力 1 5 9～ 2 73MPa、质量流速 4 88～ 2 0 80kg (m2 ·s)、临界含汽率 -0 2 0～ 0 3 0的工况范围内 ,采集了 1 70个 4× 4棒束CHF实验数据 ,并与压力 9 9～ 1 6 2MPa、质量流速 2 74～ 1 4 73kg (m2 ·s)、临界含汽率 -0 2 0～0 3 4工况范围内 ,以水为工质相同棒束实验段内的 2 0 6个棒束CHF实验数据进行比较 ,发现Ahmad补偿失真模型、张振杰模型和Stevens Kirby模型在上述工况范围内不再适用于棒束CHF的模化 ,这些模型的预测偏差均大于 2 0 %以上 ,而且棒束CHF模化的流量模化因子k明显地受压力、质量流量和入口含汽率的影响。据此提出适用于上述工况范围内 4× 4棒束CHF模化的流量模化因子k的关系式 ,其CHF预测偏差在± 1 5 %以内 ,均方根误差为 7 0 5 %。     

建筑节能发展缓慢的原因及其对策

我国实施建筑节能已近10年，但仍然只停留在试点、示范的层面上，尚未扩大到整体．分析了造成建筑节能发展缓慢的原因，并提出了推行和普及建筑节能的对策．     

Barrier layer effect of tantalum on the electromigration in sputtered copper films on hydrogen silsesguioxane and SiO2

As IC devices scale down to the submicron level, the resistance-capacitance (RC) time delays are the limitation to circuit speed. A solution is to use low dielectric constant materials and low resistivity materials. In this work, the influence of underlying barrier Ta on the electromigration (EM) of Cu on hydrogen silsesquioxane (HSQ) and SiO₂ substrates was investigated. The presence of a Ta barrier not only improves the adhesion between Cu and dielectrics, but also enhances the crystallinity of Cu film and improves the Cu electromigration resistance. The activation energy obtained suggests a grain boundary migration mechanism and the current exponent calculated indicates the Joule heating effect.     

不含4圈的最大简单图边数的下界

证明了具有不小于6个顶点的不包含4圈的简单图的最大可能边数的下界是2n-5。     

一种智能卡口令认证方案的分析与改进

袁,吕提出了一种智能卡口令认证方案.在他们的方案中,用户能随意更改口令,远程系统不需要存储用户的口令表或验证表,并能防止重放攻击.作者指出袁-吕方案不能抵抗假冒攻击,并进行了改进.     

ANOM在质量控制中的应用

ANOM（均值分析）是一种有效的质量工具，可以用来分析实验因素对输出的影响是否显著。可以应用于单因子，双因子的实验设计，无论是计量值数据，还是计数值数据，ANOM检验异常值的能力都很强，介绍了ANOM的基本分析过程，对ANOM和ANOVA进行了检验异常值灵敏度大小的比较，同时给出了实例。