Sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) have been considered as attractive alternatives for next-generation battery systems, which have promising application potential due to their earth abundance of potassium and sodium, high capacity and suitable working potential, however, the design and application of bi-functional high-performance anode still remain a great challenge up to date. Bismuth sulfide is suitable as anode owing to its unique laminar structure with relatively large interlayer distance to accommodate larger radius ions, high theoretical capacity and high volumetric capacity etc. In this study, dandelion-like Bi2S3/rGO hierarchical microspheres as anode material for PIBs displayed reversible capacity, and 206.91 mAh·g−1 could be remained after 1,200 cycles at a current density of 100 mA·g−1. When applied as anode materials for SIBs, 300 mAh·g−1 could be retained after 300 cycles at 2 A·g−1 and its initial Coulombic efficiency is as high as 97.43%. Even at high current density of 10 A·g−1, 120.3 mAh·g−1 could be preserved after 3,400 cycles. The Na3V2(PO4)3@rGO//Bi2S3/rGO sodium ion full cells were successfully assembled which displays stable performance after 60 cycles at 100 mA·g−1. The above results demonstrate that Bi2S3/rGO has application potential as high performance bi-functional anode for PIBs and SIBs.
Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV
infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the
immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall
survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed
immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and
immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network construction
were performed to explore the differentially expressed genes (DEGs). The analysis identified 425 DEGs, which
included 295 up-regulated genes and 130 down-regulated genes. We established that upregulation of CCL5 was
correlated with significantly better survival, meaning that CCL5 expression could serve as a novel prognostic
biomarker for CESC patients. We further focused on CCL5 as a hub gene in CESC, as it had significant correlations
with increased numbers of several types of immune cells. Cell-type fractions of M1 macrophages were significantly
higher in the high-immune-scores group, which was associated with better overall survival. Finally, we concluded that
CCL5 is a promising prognostic biomarker for CESC, as well as a novel chemotherapeutic target. 相似文献