智脑胶囊对实验性AD 模型大鼠学习记忆及自由基代谢的影响

目的 观察智脑胶囊对实验性AD 模型大鼠学习记忆及自由基代谢的影响。方法 采用β-淀粉样蛋白(β-AP) 大鼠侧脑室注射, 联用转移生长因子β1(TGF β1) 脑内注射, 制作实验性AD 大鼠模型。在此基础上, 应用避暗法和水迷路法测定AD 模型大鼠学习记忆功能, 并采用黄嘌呤氧化酶法、硫代巴比妥酸比色法分别测定实验性AD 模型大鼠脑组织超氧化物歧化酶(SOD) 活性和丙二醛(MDA) 含量。结果 经改进由β-AP 联用TGF β1 诱导的AD 模型大鼠既表现有行为学改变(学习记忆障碍), 又有典型的AD 病理学特征(β-AP 沉积斑), 同时模型大鼠脑组织SOD 活性明显下降, MDA 含量显著增加。智脑胶囊能有效地改善实验性AD 模型大鼠学习记忆功能, 提高模型大鼠脑组织SOD 活性, 减少MDA含量。结论 智脑胶囊能明显提高β-AP 联用TGFβ1 诱导的实验性AD 模型大鼠学习记忆能力, 其机制与清除自由基密切相关。     

Emulsion-forming properties of heat-induced pork myofibrillar protein affected by NaCl

The emulsification characteristics of myofibrillar proteins (MPs) with different NaCl concentrations also affect the quality of meat products after cooking. We investigated the effects of heating (100 °C) on the solubility, emulsifying activity, and conformational and environmental changes of MPs prepared with different NaCl concentrations. Emulsifying activity increased with increasing NaCl prior to heating, but there was no significant effect after heating. The viscosity increased and particle size decreased with increasing NaCl before heating, but these properties did not change after heating. NaCl did not affect the amount of α-helix and β-sheet. We deduced that the different emulsifying activity of myofibrillar proteins with different NaCl concentrations after heating may have been due to changes in the local environment of MPs. An understanding of the physicochemical and functional properties of MPs would unlock an area for development of meat products at different NaCl and temperature in the food industry.     

An approach to improve active disturbance rejection control

ABSTRACT

In order to reduce the error and phase delay of the classical extended state observer (ESO) in estimating the system state and disturbance, in this paper, we combine ESO and tracking differentiator (TD) to construct a tracking differential extended state observer (TDESO). The observation error and observation speed of TDESO are also discussed. Then a nonlinear active disturbance rejection control system improved by TDESO for a linear plant is transformed into a Lurie system. Moreover, the circular criterion is used to analyse the absolute stability of the transformed Lurie system. Finally, TDESO is optimised and an improved linear state error feedback (PLSEF) is proposed to improve the rapidity of the system by using simulation and time domain analysis. And a second-order system is used to illustrate the performance of the proposed scheme. The simulation results show that our algorithm is effective.     

Accelerating Data Transfer in Dataflow Architectures Through a Look-Ahead Acknowledgment Mechanism

The dataflow architecture, which is characterized by a lack of a redundant unified control logic, has been shown to have an advantage over the control-flow architecture as it improves the computational performance and power efficiency, especially of applications used in high-performance computing (HPC). Importantly, the high computational efficiency of systems using the dataflow architecture is achieved by allowing program kernels to be activated in a simultaneous manner. Therefore, a proper acknowledgment mechanism is required to distinguish the data that logically belongs to different contexts. Possible solutions include the tagged-token matching mechanism in which the data is sent before acknowledgments are received but retried after rejection, or a handshake mechanism in which the data is only sent after acknowledgments are received. However, these mechanisms are characterized by both inefficient data transfer and increased area cost. Good performance of the dataflow architecture depends on the efficiency of data transfer. In order to optimize the efficiency of data transfer in existing dataflow architectures with a minimal increase in area and power cost, we propose a Look-Ahead Acknowledgment (LAA) mechanism. LAA accelerates the execution ow by speculatively acknowledging ahead without penalties. Our simulation analysis based on a handshake mechanism shows that our LAA increases the average utilization of computational units by 23.9%, with a reduction in the average execution time by 17.4% and an increase in the average power efficiency of dataflow processors by 22.4%. Crucially, our novel approach results in a relatively small increase in the area and power consumption of the on-chip logic of less than 0.9%. In conclusion, the evaluation results suggest that Look-Ahead Acknowledgment is an effective improvement for data transfer in existing dataflow architectures.

     

混和进化算法求解具有分段恶化效应的并行机调度问题

本文提出了一种新的混合进化算法求解具有线性恶化的并行机调度问题,目标是使总完工时间最小.该算法采用对立策略以及最小比率优先规则生成初始种群,并且引入种群多样度指标加快算法的收敛;同时加入含有3-opt扰动算子的变邻域搜索算法对遗传算法得到的结果进行局部搜索.通过对不同规模算例的实验进行仿真,其结果与传统GA和VNS算法相比,效果均有所提升.     

A Non-Stop Double Buffering Mechanism for Dataflow Architecture

两倍缓冲是有效机制隐藏在在薄片上和离开薄片记忆之间的数据转移的潜伏。在 dataflow 建筑学,因为 dataflow 加速器的重复充满并且排干,然而,交换二在许多瓦减少的执行期间缓冲性能。在这个工作,我们为 dataflow 建筑学建议连续双的缓冲机制。没有停止通过在 dataflow 建筑学优化控制逻辑处理元素的执行,建议不停的机制把瓦分到处理元素数组。而且,我们建议一个工作流节目与连续双的缓冲机制合作。在控制逻辑上并且在工作流节目上的优化以后,充满并且排干数组需要越过属于一样的 dataflow 图的所有瓦的执行被做仅仅一次。试验性的结果证明没有优化,为 dataflow 建筑学的建议双缓冲机制在那上完成 16.2% 平均效率改进。     

A New Strategy for Quantitative Proportions in Complex Systems of Blended Oils by Triacyglycerols and Chemometrics Tools

Many oils sold in China and India are a blend of various oils to improve performance, stability, and nutritional characteristics, which are required in their respective markets. Quantitative analysis of the proportions of constitutive components is fundamental to the conformity and adulteration checking of edible blended oil products. A multi linear regression model with constrained linear least squares and exhaustion calculation was applied in this study. The source of the varieties in the model is a database (614 pure oils) of triacylglycerols (TAGs) collected by GC–FID and HPLC–RID. There were 20 groups of binary and ternary blended oils consisting of two or three oils out of five kinds, namely soybean, corn, peanut, rapeseed, and sunflower, which were analyzed and processed separately. Results showed that the method was able to predict the proportions of constitutive components in the edible blended oils, given that relative errors required less than 20%, the accuracy was 98.2% for the binary system if the proportion of each oil in blended oils was more than 20%, while the accuracy was 84.7% for the ternary system if the proportion of each oil in blended oils was more than 10%. The quantitative method is based on a simple analysis to determine the TAGs composition and thus it is useful for quick segregation and quality control of blended oils in routine analysis.     

非结构P2P网络受限搜索机制

降低搜索过程中产生的大量网络开销,是非结构P2P 网络重点研究内容之一.泛洪算法和随机查找算法简单且易于实现,但其在搜索过程中产生的大量冗余消息是造成大量网络开销的主要原因.针对这一问题,提出一种受限搜索机制(restricted forward search algorithm,简称RFSA),定义了搜索路径和冗余搜索路径,引入本地消息索引缓存机制,通过节点对消息的受限接收,消除节点对消息的重复接收与转发;利用搜索过程中携带的实时搜索路径信息,选择未出现在搜索路径中的邻居节点对消息进行转发,消除冗余搜索路径的产生.从理论上分析了RFSA 所产生的消息数目和网络开销.模拟实验分别从网络开销、查询点击率、搜索覆盖率和产生的冗余消息数目等方面对受限机制下和非受限机制下的泛洪算法和随机查找算法进行了对比分析,结果表明,在搜索覆盖率和查询点击率基本相同的情况下,受限机制下的泛洪算法和随机查找算法能够减少大量冗余消息的产生,降低了网络开销.     

下庄矿田蛇岭地区铀成矿地质特征及找矿方向

蛇岭地区位于下庄矿田东北部江西省境内。区内地层出露有震旦-寒武系浅变质岩系，主要出露燕山期花岗岩，基性岩脉呈岩墙产出。区内断裂构造十分发育，主要有NNE向、NEE向、NW向和EW向4组构造，控制了铀矿体（化）的空间展布。区内分布有蛇岭矿床（由307、308、617矿点组成），以及410、310、105矿点，铀矿化主要产于燕山期细不等粒白云母花岗岩和中粗粒似斑状黑云母花岗岩中，受断裂构造、花岗岩体、基性岩脉和部分受不整合面联合控制。结合该区地质工作成果，详细分析了区内铀成矿地质特征，总结了控矿因素，探讨了蛇岭矿床（307、308、617矿点）以及410、310、105矿点的找矿方向，供区内后续找矿工作参考。     

Evaluation of Eddy-Current Effects on Diamagnetic Bearings for Microsystems

Diamagnetic materials could be utilized with permanent magnets to offer a simple passive solution to micro bearings as a result of scale reduction. In this paper, we investigate the eddy-current effect on the performance of diamagnetic bearings. Due to the good electrical conductivity of some of diamagnetic materials or the intentionally introduced eddy-current damper for vibration control, eddy current could be induced in the diamagnetic bearing with viscous forces opposing the relative motion between the rotor and the stator. Such damping mechanism is analyzed with a thin-sheet model and the image method and compared with that due to aerodynamic effects so as to give an idea of its significance at the microscale. Following the calculation, extracted damping coefficients are employed in a rotor dynamic model to investigate their influence on dynamic behaviors of the bearing. Results indicated that damping provided by eddy-current effects has pros and cons for the performance of the diamagnetic bearing which involves rotational motion. Finally, rundown characteristics of the bearing are evaluated, and the implication for operation scheme is discussed.