Reduced Graphene Oxides Modified Bi2Te3 Nanosheets for Rapid Photo-Thermoelectric Catalytic Therapy of Bacteria-Infected Wounds

Temperature variation-induced thermoelectric catalytic efficiency of thermoelectric material is simultaneously restricted by its electrical conductivity, Seebeck coefficient, and thermal conductivity. Herein, Bi₂Te₃ nanosheets are in situ grown on reduced graphene oxides (rGO) to generate an efficient photo-thermoelectric catalyst (rGO-Bi₂Te₃). This system exhibits phonon scattering effect and extra carrier transport channels induced by the formed heterointerface between rGO and Bi₂Te₃, which improves the power factor value and reduces thermal conductivity, thus enhancing the thermoelectric performance of 2.13 times than single Bi₂Te₃. The photo-thermoelectric catalysis of rGO-Bi₂Te₃ significantly improves the reactive oxygen species yields, resulting from the effective electron–hole separation caused by the unique thermoelectric field and heterointerfaces of rGO-Bi₂Te₃. Correspondingly, the electrospinning membranes containing rGO-Bi₂Te₃ nanosheets exhibit high antibacterial efficiency in vivo (99.35 ± 0.29%), accelerated tissue repair ability, and excellent biosafety. This study provides an insight into heterointerface design in photo-thermoelectric catalysis.     

深圳地区电力需求侧管理的回顾和展望

深圳电网在全国率先进行DSM试点,其经验可资借鉴。深圳市政府重视节能和循环经济工作,以错峰用电为主全面加强电力需求侧管理,先后出台了一系列有利于开展工作的政策措施并取得实效。2004年深圳市单位GDP能耗下降到0.525 tce/万元,介于日本和美国水平之间。对“十一五”期间政府主导规划和推动电力需求侧管理、设立专项基金、完善电价机制、培育需求侧管理服务市场、发挥供电企业主体作用等方面提出建议。     

ER、PR阳性乳腺分泌型癌1例报告并文献复习

目的探讨乳腺分泌型癌（secretory carcinoma of the breast,SCB）的临床病理特征,以提高对SCB的认识和病理诊断水平。方法对1例SCB患者的临床表现、组织病理和组织化学染色进行分析和观察,并结合国内外相关文献复习SCB的特点。结果患者为38岁女性,左乳单发肿物。组织病理学形态主要为实性、小管状及小囊腔状结构。肿瘤细胞分2种类型：一种胞浆内含嗜酸性分泌物,另一种胞质淡染甚至呈空泡状。胞浆内外的分泌物对PAS及AB染色呈阳性反应。免疫组化：ER（＋＋＋）、PR（＋＋＋）、E-cad（＋）、EMA（＋）、S-100（-）。结论 SCB是乳腺癌的一个少见类型,诊断主要依据组织病理学观察,虽然手术治疗及预后较好,但仍需要终生随访。     

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues. NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers. Therefore, it could be a target for cancer therapy. Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:quinone oxidoreductase 1 to diagnose tumours. Its expression is higher in tumours than in normal tissues, and using target drugs such as β-lapachone to reduce side effects in normal tissues can help. However, the physicochemical properties of β-lapachone limit its application. The problem can be solved by using nanosystems to deliver β-lapachone. This mini-review summarizes quinone-based fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)H:quinone oxidoreductase 1-activating drug β-lapachone. This review provides valuable information for the future development of probes and nano-delivery systems that target NAD(P)H:quinone oxidoreductase 1.     

海洋石油生产储油轮发电机组控制技术研究

海洋石油生产储油轮作为海洋油气开发系统的核心部分,其发电机组控制技术要求可靠性高、抗干扰能力强、实时性好。基于西门子S7～300／400PLC,提出采用层次化冗余控制结构构建发电机组控制系统：底层控制结构划分为各独立子系统,中间层控制站控制底层子系统协调工作,顶层系统实现人机交互以及系统监控;设计了各层控制系统硬件及软件结构;论述了层之间数据通信实现方式。系统具有开放性、智能性及易维护性等优点。     

重庆金融中心结构设计

重庆金融中心由办公楼和酒店组成,分别高178m和183.5m,结构体系均为框架－钢筋混凝土核心筒结构.初步设计阶段采用2个不同力学模型的三维空间分析软件SATWE和MIDAS进行结构整体内力和位移计算,以满足规范的各项要求,通过静力弹塑性分析找出结构的薄弱部位,并采取针对性的抗震加强措施,同时最大层间位移角满足规范规定...     

编码器IME6400在远程监控传输中的应用

介绍IEM6400的性能特点和引脚功能,以及其视频编码接口、时钟、外部信号,并给出了基于IME6400嵌入式PC内核的数字视频监控传输系统的设计。     

一种新型变曲率柔性关节微创手术机械手设计

针对狭窄工作空间,微创手术机器人受限于机械手末端执行器灵活度不足,导致医生无法有效进行手术操作的问题.本论文提出一种新型变曲率柔性关节微创手术机械手,通过刚柔体同轴嵌联结构,控制外层柔性关节机加工弹簧和内层刚性基杆的耦合长度,实现机械手前端连续变曲率万向弯曲运动.论文阐述了机械手柔性关节设计、动力传递实现方法及使用AN...     

国外PSA技术标准和应用导则适用性评价

介绍了国际上对PSA开发质量和应用过程进行规范的技术标准和导则,以ASME标准和RG1.174、RG1.177为例,对这些标准和导则的适用性进行了分析,并结合我国的PSA开发与应用趋势,提出了建立我国技术标准和导则的建议。     

靶控输注异丙酚不同麻醉深度对兔脑神经元型一氧化氮合酶mRNA水平的影响

目的: 研究异丙酚不同麻醉深度对兔脑神经元型一氧化氮合酶(nNOS)mRNA水平的影响。方法: 30只日本大耳兔,随机分为3组:对照组,浅麻醉组,深麻醉组,每组10只。浅麻醉组、深麻醉组予以异丙酚靶控输注,达到所需麻醉状态后1h断头处死。对照组行耳缘静脉注射空气造成空气栓塞后致死。动物处死后0～4℃分离取脑,原位杂交法测定小脑皮质、大脑顶叶皮质nNOSmRNA表达水平。结果: 与对照组比较,异丙酚麻醉状态下明显抑制兔大脑顶叶皮质、小脑皮质nNOSmRNA表达水平(P<0.05)。随麻醉深度的加深,小脑皮质nNOS表达水平进一步明显降低(P<0.05),但大脑顶叶皮质nNOS表达水平并未进一步降低(P>0.05)。结论: 异丙酚可能通过抑制nNOS活性,降低NO、环磷酸鸟苷(cGMP)水平,从而发挥麻醉作用。异丙酚对nNOS活性的抑制存在脑区差异。