Current Urban Discourse,Urban Transformation and Gentrification in Istanbul

In the mid-2000s, unprecedented economic growth provided a catalyst for Istanbul's transformation. Tolga İslam outlines the background to large-scale urban development and renewal projects that have been undertaken by local authorities throughout the city. Copyright © 2010 John Wiley & Sons, Ltd.     

对现行高校财务管理模式的思考

分析了我国高校的财务管理工作存在的不足及问题,并提出了相应的改革措施.     

关于城市规划行政许可若干问题的思考

根据《行政许可法》的规定,现行有效的规划许可事项主要包括建设项目选址规划许可、建设用地规划许可和建设工程规划许可。县级以上的规划主管部门是法定的规划许可主体,设区的市所辖区、各类开发区的规划管理机构及建制镇政府均不享有规划许可主体资格。《行政许可法》规定的许可条件和程序、监督与责任等无条件适用于规划许可,规划管理实践中必须严格执行,同时注意找准规划许可与《行政许可法》的切入点。     

光电子技术在信息化作战中的应用

现代信息化战争的特点决定了未来信息化作战中交战双方更加注重争夺制信息权、制空权。各类用于争夺制空权、制信息权的光电武器装备纷纷投入战场,加之精确制导武器的使用,彻底改变了现代战争的形式和方式,催生了新的作战模式。主要探讨了未来信息化战场光电子技术在夺取制信息权、制空权,精确打击中的一些典型运用,并就弱势一方如何进行有效手段进行光电对抗,在强大的光电武器打击下如何取得战场生存,最后取得胜利进行了分析,并给出了结论。     

Determination of pesticide residues in food matrices using the QuEChERS methodology

The determination of pesticide residues in food matrices is a formidable challenge mainly because of the small quantities of analytes and large amounts of interfering substances which can be co-extracted with analytes and, in most cases, adversely affect the results of an analysis. However, safety concerns require that pesticides of the wide range of chemical properties (including acidic, basic and neutral) should be monitored. Because of the wide variety of food matrices, the sample must initially be cleaned up before final analysis. That is why the analytical chemist is faced with the need to devise new methodologies for determining such residues to be determined in a single analytical run. To accomplish the goal, QuEChERS methodology has been developed. It is a streamlined and effective extraction and cleanup approach for the analysis of diverse analyte residues in food matrices. So far, there have been achieved promising results by liquid or gas chromatography analysis, including pesticides, but also acrylamide, pharmaceuticals and veterinary drugs.     

地方政府公共行政中的"塔西佗陷阱"探析

当前,由于各种原因导致地方政府在公共行政中陷入了"塔西佗陷阱". "塔西佗陷阱"的实质是社会公众对政府的政治信任问题. 要提高社会公众对地方政府的政治信任,破解"塔西佗陷阱",不但要确立明晰的产权关系,树立正确的政绩观,还要建立完善的制度体系,依法实行"阳光行政",同时正确引导公共话语、构建服务型政府、加强公职人员诚信建设.     

A review of digital twin in product design and development

In the era of digitalization, there are many emerging technologies, such as the Internet of Things (IoT), Digital Twin (DT), Cloud Computing and Artificial Intelligence (AI), which are quickly developped and used in product design and development. Among those technologies, DT is one promising technology which has been widely used in different industries, especially manufacturing, to monitor the performance, optimize the progresses, simulate the results and predict the potential errors. DT also plays various roles within the whole product lifecycle from design, manufacturing, delivery, use and end-of-life. With the growing demands of individualized products and implementation of Industry 4.0, DT can provide an effective solution for future product design, development and innovation. This paper aims to figure out the current states of DT research focusing on product design and development through summarizing typical industrial cases. Challenges and potential applications of DT in product design and development are also discussed to inspire future studies.     

工程建设合同管理软件的开发和应用

本文介绍了工程建设合同管理软件的主要用途,编程思路。     

Building a drug development database: challenges in reliable data availability

Abstract

Context: Policy and legislative efforts to improve the biomedical innovation process must rely on a detailed and thorough analysis of drug development and industry output.

Objective: As part of our efforts to build a publicly-available database on the characteristics of drug development, we present work undertaken to test methods for compiling data from public sources. These initial steps are designed to explore challenges in data extraction, completeness and reliability. Specifically, filing dates for Investigational New Drugs (IND) applications with the U.S. Food and Drug Administration (FDA) were chosen as the initial objective data element to be collected.

Materials and methods: FDA’s Drugs@FDA database and the Federal Register (FR) were used to collect IND dates for the 587 New Molecular Entities (NMEs) approved between 1994 and 2014. When available, the following data were captured: approval date, IND number, IND date and source of information.

Results: At least one IND date was available for 445 (75.8%) of the 587 NMEs. The Drugs@FDA database provided IND dates for 303 (51.6%) NMEs and the FR contributed with 297 (50.6%) IND dates. Out of the 445 NMEs for which an IND date was obtained, 274 (61.6%) had more than one date reported.

Discussion: Key finding of this paper is a considerable inconsistency in reliably available or reported data elements, in this particular case, IND application filing dates as assembled from publicly-available sources.

Conclusion: Our team will continue to focus on finding ways to collect relevant information to measure impact of drug innovation.     

面向拜登政府的过渡期网络安全建议

美国网络空间日光浴委员会为新上任的拜登政府提出的网络安全建议。重点建议拜登政府在上任头100天内组建国家网络总监办公室,制定和颁布国家网络战略,改善当前政府网络安全工作的连贯性和影响力,并进一步加强与私营部门的合作关系。同时阐述了拜登政府此后应优先开展的七项工作,以及白宫和国会应围绕网络安全展开立法合作的六个领域。