433MHz物联网开发平台的设计与开发

物联网是当前信息领域中研究的热点。本文以CC1110芯片为核心,利用温湿度、烟雾、亮度等传感器结合自主开发的WIA-PA协议栈软件,研制了一种基于433MHz频段的物联网开发平台。利用该平台提供的开发套件,可方便地开发智能家居、环境监测等应用系统。目前,重庆伟岸测器利用本平台已成功开发了无线热能表系统。     

基于J2EE平台软件开发

在特定框架的基础上建立目标应用系统是当前Web应用开发的主流,如面向J2EE平台的Struts、Spring、JSF、Cocoon、Axis和Xalan等框架都得到了广泛的应用。这些框架是软件开发人员从以往的经验和教训中总结出的设计模式。这些模式的应用,不仅降低了软件开发的成本,同时也保证了Web应用系统的质量。     

一种基于多Agent的人群仿真多机并行平台研究

本文提出了一种针对多Agent人群仿真模型的多机并行平台,该平台利用MPI作为节点间的通讯软件,采用主从模式设计多机并行执行环境。在主控节点中设置结果回收模块与监控模块,通过K-means算法保证执行节点之间的负载均衡,同时以此作为任务分发与调度的依据;在执行节点(从节点)中,则根据主控节点的任务调度执行相关Agent模型,并执行仿真同步与状态信息汇报等任务。实验结果表明,该多机并行平台能够执行基于多Agent的人群仿真模型,能有效地提高仿真的性能,同时具有良好的可扩展性。     

实验室网络教学资源与人才培养创新理论的研究

实验室网络教学资源与人才培养创新理论的研究,要灵活多样,寻求多种途径,利用虚拟实验室及网络等现有资源,开展开放式实验实训和校外实训,利用远程教学,将实训教学与职业技能鉴定相结合,以网络资讯平台为基础,通过电视式校园媒体平台,以市场为导向的方针,规划人力资源,以就业为核心的现代化的传输手段,实现适应市场需求的各类人才的培养计划,努力建设一个以高校校园市场为基础的、完善的、能沟通企业、学校和学生的产、教、学信息平台。     

两轴稳定平台大俯仰角状态控制技术研究

在对两轴稳定平台一般构型分析的基础上,指出了其在俯仰方向大角度时稳定控制存在的不足,提出了采用三正交陀螺稳定控制方式解决大俯仰角控制问题的方法,最后利用MATLAB进行了数学仿真,结果表明该方法有效提高了系统的稳定精度。     

车载多层减振平台的主动控制及仿真

为了研究被动悬架车载主动减振平台的低成本控制策略及其减振效果,针对一种新型长宽比较大的多层减振平台,建立了车辆被动悬架与主动减振平台的一体化全系统动力学分析模型。进而,设计了"线性被动、旋转主动"的平台控制策略,并应用MATLAB及ADAMS软件,在三种典型路面激励下,进行了仿真测试。结果表明:采用垂向线性振动的多层被动减振、旋转振动的低成本主动控制策略,被动悬架车载减振平台的减振效果明显,实现了车载减振平台的高性价比设计。     

Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels

The voltage-gated proton channel, Hv1, also termed VSOP, was discovered in 2006. It has long been suggested that proton transport through voltage-gated proton channels regulate reactive oxygen species (ROS) production in phagocytes by counteracting the charge imbalance caused by the activation of NADPH oxidase. Discovery of Hv1/VSOP not only confirmed this process in phagocytes, but also led to the elucidation of novel functions in phagocytes. The compensation of charge by Hv1/VSOP sustains ROS production and is also crucial for promoting Ca²⁺ influx at the plasma membrane. In addition, proton extrusion into neutrophil phagosomes by Hv1/VSOP is necessary to maintain neutral phagosomal pH for the effective killing of bacteria. Contrary to the function of Hv1/VSOP as a positive regulator for ROS generation, it has been revealed that Hv1/VSOP also acts to inhibit ROS production in neutrophils. Hv1/VSOP inhibits hypochlorous acid production by regulating degranulation, leading to reduced inflammation upon fungal infection, and suppresses the activation of extracellular signal-regulated kinase (ERK) signaling by inhibiting ROS production. Thus, Hv1/VSOP is a two-way player regulating ROS production. Here, we review the functions of Hv1/VSOP in neutrophils and discuss future perspectives.     

Plumbagin,a Biomolecule with (Anti)Osteoclastic Properties

Plumbagin is a plant-derived naphthoquinone that is widely used in traditional Asian medicine due to its anti-inflammatory and anti-microbial properties. Additionally, plumbagin is cytotoxic for cancer cells due to its ability to trigger reactive oxygen species (ROS) formation and subsequent apoptosis. Since it was reported that plumbagin may inhibit the differentiation of bone resorbing osteoclasts in cancer-related models, we wanted to elucidate whether plumbagin interferes with cytokine-induced osteoclastogenesis. Using C57BL/6 mice, we unexpectedly found that plumbagin treatment enhanced osteoclast formation and that this effect was most pronounced when cells were pre-treated for 24 h with plumbagin before subsequent M-CSF/RANKL stimulation. Plumbagin caused a fast induction of NFATc1 signalling and mTOR-dependent activation of p70S6 kinase which resulted in the initiation of protein translation. In line with this finding, we observed an increase in RANK surface expression after Plumbagin stimulation that enhanced the responsiveness for subsequent RANKL treatment. However, in Balb/c mice and Balb/c-derived RAW264.7 macrophages, these findings could not be corroborated and osteoclastogenesis was inhibited. Our results suggest that the effects of plumbagin depend on the model system used and can therefore either trigger or inhibit osteoclast formation.     

高空作业平台臂架伸缩运动的横向振动特性

为了探究高空作业平台做伸缩运动时变幅平面内的横向振动动力学特性,针对臂架的实际搭接和支承情况,将臂架等效为根部铰接、中间弹性支承且带有集中参数的变截面变长度梁. 基于牛顿第二定律建立各臂段的运动微分方程,采用模态叠加法、结合边界条件求解臂架一系列时刻的瞬态振型函数,曲线拟合时变参数以近似表示梁的振型,并依据伽辽金截断方法,得到广义坐标下的状态空间方程. 在Matlab/Simulink环境下进行动态仿真,得到伸缩过程中臂架头部的变幅平面横向振动动态响应. 结果表明,就横向振动振幅而言,搭接简化会带来15.63%计算结果误差;支承简化会加大臂架整体刚度、减小臂架振动响应,不可取。     

基于多速度元胞自动机的海洋平台人员疏散

为了研究海洋平台人员疏散过程,定量评估疏散方案的合理性,基于元胞自动机模型开发适用于海洋平台人员逃生疏散的仿真系统,提出在离散模型中精确考虑多种人员速度的方法. 使用真实海洋平台疏散实验数据校核模型参数,并对比商业软件maritimeEXODUS的计算结果,验证仿真系统的可行性. 从疏散时间和出口使用效率对无烟和有烟场景下的人员疏散结果进行对比和量化分析,并提出优化方案. 结果表明：有烟环境不仅折减人员移动速度,延长疏散时间,更会影响人员的路径选择,导致疏散不平衡.