Objective: Establish an effective experimental strategy to determine the compatibility of rubber closures for drugs.
Significance: Various types of rubber closures with different compositions are available for drug packaging. Many additives of rubber closures can be released from rubber closures and may affect the quality of drugs and pose a risk to human health. In this study, we aimed to determine the relationship between cephalosporin structure, solution clarity, and rubber closure compatibility using volatile components profile of butyl rubber closures.
Methods: Two opposite polarity gas chromatography (GC) systems and GC-mass spectrometry (MS) were used to achieve rapid qualitative determination of the main volatile components in rubber closures. Simulated adsorption experiment was performed to investigate the adsorption of main volatile components in rubber closures by cephalosporins with different side chain structures, and to determine the effects of adsorption on solution clarity.
Results: A volatile components screening library of rubber closures was established and the structures of some volatile component were confirmed. The specific adsorption of the structure of cephalosporins on volatile components from rubber closures was studied.
Conclusion: Based on the results of this study, rubber closures with good compatibility for cephalosporins with different side chain structures can be selected rapidly. This experimental strategy not only facilitates the screening of suitable rubber closures more effectively, but also enables the quick determination of volatile components adsorbed by drugs. 相似文献
The present study aimed to identify the potential existence of spatio-temporal variability in the fatty acid (FA) profile of the adductor muscle (AM) of a commercially important bivalve, the common cockle Cerastoderma edule, and determine if such variability can be used to trace their geographic origin post-harvesting. Common cockles were sampled in eight ecosystems along the coast of mainland Portugal, as well as in two different channels within one of those ecosystems over two consecutive years. Results showed significant differences in FA profiles among ecosystems, namely due to different levels of eicosapentaenoic acid (EPA; 20:5n-3), arachidonic acid (20:4n-6), ratio of polyunsaturated FA (PUFA) n-3/n-6, monounsaturated FA (MUFA; 18:1n-9 and 20:1n-9/11) and bacterial FA (15:0, 17:0 and 18:1n-7). FA profiles also displayed significant differences between two consecutive years in channels from the same ecosystem. Overall, while the FA profile displayed by the AM of C. edule can be successfully used to trace their geographic origin, the existence of temporal variability requires a periodical verification of FA signatures to identify potential shifts, namely when comparing specimens from the same ecosystem. 相似文献