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Dr. Ying Wang Prof. Dr. Andrew Ewing 《Chembiochem : a European journal of chemical biology》2021,22(5):807-813
Exocytosis plays an essential role in the communication between cells in the nervous system. Understanding the regulation of neurotransmitter release during exocytosis and the amount of neurotransmitter content that is stored in vesicles is of importance, as it provides fundamental insights to understand how the brain works and how neurons elicit a certain behavior. In this minireview, we summarize recent progress in amperometric measurements for monitoring exocytosis in single cells and electrochemical cytometry measurements of vesicular neurotransmitter content in individual vesicles. Important steps have increased our understanding of the different mechanisms of exocytosis. Increasing evidence is firmly establishing that partial release is the primary mechanism of release in multiple cell types. 相似文献
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Analog integrated circuit design has as integral parts both analytical reasoning and numerical validation in the process from topology construction to sizing. Given a circuit topology, different circuit sizing results can be obtained from different processes of sizing inference. Sizing methods by simulation-based numerical searching have been a continuously studied subject. However, almost all approaches in this category require an overwhelming number of circuit simulations to arrive at an optimized sizing result. On the other hand, many published manual sizing methods by using the conventional device equations also require repeated SPICE simulations to correct the equation-based sizing results. This paper proposes a systematic gm/ID-based initial sizing method specifically customized for designing multiple-stage operational amplifiers (Op Amps). A main feature of the proposal is to use circuit-level design equations as constraints on the gm/ID table lookup method to substantially reduce the uncertainty in the sizing calculations. As a result, a significant amount of SPICE based correction work can be reduced to complete an initial sizing. The proposed sizing procedure includes a few regular sizing rules customized to the configuration of multi-stage Op Amps. We validate the proposed sizing method by application to several multi-stage Op Amp examples with a capacitive load or Miller compensation. Simulations have justified that the produced initial sizing results can achieve most of the prespecified design targets. 相似文献
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2018年初,我国提出“乡村振兴”战略,此战略目的是增强农村农业发展的新活力,从而加速推进其现代化进程。光纤有线电视因具有损耗小、传输距离远、频带宽、传输容量大、抗电磁干扰等实用优势,并在贯彻及落实着“社会效益优先,两个效益统一”的原则下在社会、经济及文化等方面助力着乡村的振兴。 相似文献
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现有文献针对计及转子变流器(RSC)控制的双馈感应风电机组(DFIG)定子短路电流解析表达,将定子磁链当作一阶直流衰减分量或忽略功率外环控制。基于DFIG电压、磁链和RSC控制方程,得到定子电流关于定子电压和定子功率的传递函数,提出定子电流的精确解析表达式。基于RSC内、外环PI参数关系,推导直流分量衰减时间常数和角频率关于PI参数的表达式。分析了RSC内外环PI参数对定子电流直流衰减分量的影响。仿真结果验证了解析表达式的准确性,为PI参数选取和保护装置测量、整定提供依据。 相似文献
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永磁无刷直流电机是近些年发展起来的一种新型电机,具有效率高、调速性能好、启动转矩大等诸多优点,在运动控制领域中的应用日趋广泛。基于电机专用控制芯片MC33035,采用单片机C8051F500为主控芯片,设计一款无刷直流电机智能控制器,实现对无刷直流电机启动停止、正反转、调速、转速显示等控制。通过简要介绍无刷直流电机工作原理,使用MATLAB/Simulink对控制系统进行建模仿真,对无刷直流电机控制系统进行软、硬件设计。实验结果表明,该控制系统运行稳定,抗干扰性强,具有良好的市场应用价值。 相似文献
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Radio-Frequency (RF) energy harvesting must cope with the limited availability and high variability of the energy source. In this paper, the modeling of an RF harvester for ultra low power environments is presented. A mathematical model based on theoretical analysis is developed. The model demonstrates that the maximum transferred power point is located in a three-dimensional space defined by the input capacitance, the output voltage, and the load resistance of the rectifier circuit. Moreover, the mathematical model returns results in substantial agreement with the SPICE simulation results, while guaranteeing a remarkable reduction of the required computation time. Furthermore, the paper reports the implementation of a mixed signal system for the 3-D MPPT, to be embedded in an RF harvester, in a 65 nm CMOS technology. The circuit exhibits a simulated power consumption lower than 100 nW, making this solution suitable for ultra low power harvesting. 相似文献
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ABSTRACT Supply chains are becoming increasingly complex, and many companies and researchers are looking to nature for finding solutions. In this paper, we provide a narrative synthesis and systematic review to explore state-of-the-art, and identify key areas for exploration of nature inspired solutions in the supply chain area. We consider strategic, tactical, and operational decisions within supply chains and identify analogies between biological systems and supply chains to create a new research agenda. Our findings show that the majority of the research in nature inspired supply chains from the systemic perspective focuses on closed loop supply chains. In contrast, similar systemic solutions such as industrial symbiosis, circular economy, and industrial ecology have not been explored as frequently. Reducing production waste (industrial symbiosis) in addition to end-of-life product waste (closed loop supply chains), optimising raw material use and extending the life of used resources (circular economy), investigating the interactions between biosphere and technosphere (industrial ecology), and seeking solutions to industrial problems from nature (biomimicry) are all possible paths for reaching a zero-waste economy. These systemic solutions have a considerable impact on the supply chains at the strategic, tactical, and operational levels, which need to be explored to identify efficient and effective solutions. 相似文献
10.
对我国常用的闭口闪点测定方法宾斯基-马丁闭口杯法、阿贝尔闭口杯法和泰格闭口杯法的测定原理进行对比分析,并采用这3种方法分别对2种有证标准样品、4种有机试剂样品和7种喷气燃料样品的闭口闪点进行测定。结果表明:这3种方法在适用范围、仪器结构、升温速率和点火操作要求等方面都有一定差异,导致采用这3种方法测定同一样品的闭口闪点结果略有差异,闪点测定结果之间的最大差值与样品闪点的高低呈正相关;与阿贝尔闭口杯法相比,宾斯基-马丁闭口杯法测得的闪点结果较高,对于3号喷气燃料,二者之差为0~1.0 ℃,阿贝尔闭口杯法更适合3号喷气燃料闭口闪点的测定;对于纯有机试剂样品,阿贝尔闭口杯法和宾斯基-马丁闭口杯法测得的闪点结果呈现较好的线性关系。 相似文献