Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. We examined AID expression in IgG4-related ophthalmic disease (IgG4-ROD; n = 16), marginal zone lymphoma with IgG4-positive cells (IgG4+ MZL; n = 11), and marginal zone lymphoma without IgG4-positive cells (IgG4- MZL; n = 12) of ocular adnexa using immunohistochemical staining. Immunohistochemistry revealed significantly higher AID-intensity index in IgG4-ROD and IgG4+ MZL than IgG4- MZL (p < 0.001 and = 0.001, respectively). The present results suggest that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation, and AID may be a driver of oncogenesis in IgG4-ROD to IgG4+ MZL.     

Full AC analysis of value of DER to the grid and optimal DER scheduling

This paper presents part of the work ComEd and Quanta Technology have performed to quantify the locational and temporal value of DER to avoid distribution grid upgrade investments. It focuses on the formulation of a robust and efficient algorithm for DER optimal dispatch on a distribution feeder to mitigate the violation of current and voltage limits using the allocated cost of capacity and locational marginal value of real and reactive DER injection/withdrawal.     

Physiologically Active Molecules and Functional Properties of Soybeans in Human Health—A Current Perspective

In addition to providing nutrients, food can help prevent and treat certain diseases. In particular, research on soy products has increased dramatically following their emergence as functional foods capable of improving blood circulation and intestinal regulation. In addition to their nutritional value, soybeans contain specific phytochemical substances that promote health and are a source of dietary fiber, phospholipids, isoflavones (e.g., genistein and daidzein), phenolic acids, saponins, and phytic acid, while serving as a trypsin inhibitor. These individual substances have demonstrated effectiveness in preventing chronic diseases, such as arteriosclerosis, cardiac diseases, diabetes, and senile dementia, as well as in treating cancer and suppressing osteoporosis. Furthermore, soybean can affect fibrinolytic activity, control blood pressure, and improve lipid metabolism, while eliciting antimutagenic, anticarcinogenic, and antibacterial effects. In this review, rather than to improve on the established studies on the reported nutritional qualities of soybeans, we intend to examine the physiological activities of soybeans that have recently been studied and confirm their potential as a high-functional, well-being food.     

迁钢210 t钢包全程加盖工艺及实践

迁钢二炼钢厂自投入使用210 t钢包全程加盖技术及工艺后，取得了显著效果，平均出钢温度降低10 ℃，钢包热周转使用率长期保持在85%以上，取消了钢包在线烘烤，降低了煤气消耗，有效地保证了钢包洁净度，提高了钢包包衬寿命。实践生产运行表明，炼钢生产中钢包全程加盖工艺是一项节能、环保、降耗的先进技术，为迁钢二炼钢厂取得了显著的经济效益。但在一段时间内，该工艺运行稳定性较差，通过现场生产数据归纳分析，从中找出了影响钢包加、揭盖的因素，并制定了控制措施；同时，岗位要掌握其操作要点及主要设备，才能提高运行稳定性。     

The Marginal Density of a TMA(1) Process

This note reconsiders the marginal density of a threshold moving average process and proposes a simple yet effective numerical algorithm to implement that by solving an associated integral equation. This algorithm can also be applied to calculate stationary probability density or distribution functions of a few other types of nonlinear stationary stochastic processes numerically.     

Social licence: power imbalances and levels of consciousness – two case studies

ABSTRACT

Social licence to operate (SLO) is a term that is finding increasing acceptance in a number of industries. Like all new terms, its precise meaning and implications are still being investigated. Using data from previous studies, this paper offers an analysis of the SLO of two case studies with each study being viewed separately through the grid of a distinct theoretical framework. Case study 1 looks at the development of differential social licence negotiated in the Hamlet of Cambridge Bay, Nunavut, as a result of an impact and benefit agreement negotiated between Tahera Diamond Corp. and the Kitikmeot Inuit Organisation in 2004. The study demonstrates that general acceptance of resource development can be uneven and reflect an unequal distribution of decision-making power. In case study 2, stakeholders of a failed mineral development project were queried across time about the specifics of the proposed mine development and were queried about resource development across different levels of consciousness. Perhaps, SLO is variable across different levels of consciousness. The paper concludes with observations about the variable nature of SLO acceptance across populations and across levels of consciousness within individuals. Perhaps, the concept of SLO is, in fact, complex, difficult to define and measure and, at this point, of limited utility as a measure of resource development acceptance.     

Consumer perception of extruded snacks containing brown rice and dried mushroom

Effects of mushroom type, seasoning and health benefit information (HBI) on consumers’ saltiness expectation, sensory liking, elicited emotions and purchase intent (PI) of extruded snacks were investigated. Five snacks were evaluated: straw mushroom (Volvariella volvacea) extrudates without (SME) or with seasoning (SMES), phoenix mushroom (Pleurotus pulmonarius) extrudates without (PME) or with seasoning (PMES), and the control without mushroom and seasoning. Hedonic scores and positive emotions were generally higher for seasoned mushroom-containing snacks (SMES and PMES) with 65% and 75.83% of consumers reporting willingness to purchase, respectively, after receiving HBI. Bored, interested and satisfied were identified as significant emotional predictors for PI odds. Flavour, saltiness, overall liking, bored, good and interested were critical attributes, differentiating snacks. This study demonstrated that sensory liking and PI of extruded brown rice-based snacks containing mushroom could be improved through savoury seasoning addition, which also allowed saltiness expectations to be met.     

基于MED和边际谱的自动倾斜器轴承故障诊断

针对直升机自动倾斜器轴承早期微弱故障特征易被强烈背景噪声淹没的问题，提出了一种基于最小熵反褶积（Minimum Entropy Deconvolution，MED）和边际谱的自动倾斜器轴承故障诊断方法。采用MED对采集的振动信号进行滤波降噪，提高了信号的信噪比，突出了轴承早期微弱故障特征；通过Hilbert变换和经验模态分解（Empirical Mode Decomposition，EMD）获取去噪包络信号的本征模态函数（Intrinsic Mode Functions，IMF）集，并引入峭度筛选准则选取合理IMF集计算局部Hilbert边际谱，有效地提取了故障特征频率，能够通过故障特征频率进行故障类型判别。通过某型直升机自动倾斜器故障诊断试验系统验证了该诊断方法的合理性和可行性。     

面向电网实时运行风险的快速定级方法研究及应用

为满足电网运行实时风险评估时效性要求,解决电网运行实时风险评估与定级中效率与精度两者间协调的问题,在当前国家和主要电网企业规定的电网运行事故定级标准基础上提出了一种快速定级方法。快速定级方法充分考虑了电网运行实际特性,采取数据治理和算法重构两方面主要措施,对原判定方法进行优化处理。通过数据治理,大幅降低了对外部数据的依赖性,并取消了部分不必要的输入数据。采用算法重构,进一步将运行风险定级与实际业务流程紧密联系。以该快速定级方法为核心,构建了支撑电网运行风险分析与事故处置的实时运行风险管理系统,介绍了该系统的功能框架与系统架构。最后结合该系统在贵阳的实际应用情况,分析了快速定级方法的实际使用效益。