全文获取类型
收费全文 | 33430篇 |
免费 | 5732篇 |
国内免费 | 2454篇 |
专业分类
电工技术 | 10489篇 |
技术理论 | 2篇 |
综合类 | 2858篇 |
化学工业 | 1494篇 |
金属工艺 | 613篇 |
机械仪表 | 3464篇 |
建筑科学 | 1202篇 |
矿业工程 | 2465篇 |
能源动力 | 1007篇 |
轻工业 | 821篇 |
水利工程 | 876篇 |
石油天然气 | 4084篇 |
武器工业 | 512篇 |
无线电 | 2280篇 |
一般工业技术 | 1866篇 |
冶金工业 | 646篇 |
原子能技术 | 260篇 |
自动化技术 | 6677篇 |
出版年
2024年 | 142篇 |
2023年 | 653篇 |
2022年 | 1171篇 |
2021年 | 1481篇 |
2020年 | 1582篇 |
2019年 | 1169篇 |
2018年 | 1055篇 |
2017年 | 1220篇 |
2016年 | 1449篇 |
2015年 | 1587篇 |
2014年 | 2431篇 |
2013年 | 2107篇 |
2012年 | 2749篇 |
2011年 | 2691篇 |
2010年 | 1996篇 |
2009年 | 2061篇 |
2008年 | 2012篇 |
2007年 | 2317篇 |
2006年 | 2080篇 |
2005年 | 1729篇 |
2004年 | 1529篇 |
2003年 | 1303篇 |
2002年 | 984篇 |
2001年 | 910篇 |
2000年 | 736篇 |
1999年 | 587篇 |
1998年 | 370篇 |
1997年 | 310篇 |
1996年 | 267篇 |
1995年 | 234篇 |
1994年 | 155篇 |
1993年 | 129篇 |
1992年 | 115篇 |
1991年 | 84篇 |
1990年 | 67篇 |
1989年 | 41篇 |
1988年 | 23篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 10篇 |
1979年 | 6篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1959年 | 2篇 |
1951年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Liudmila Zakharova Viktoria Sharova Marina Izvolskaia 《International journal of molecular sciences》2021,22(1)
Different aspects of the reciprocal regulatory influence on the development of gonadotropin-releasing hormone (GnRH)-producing- and immune systems in the perinatal ontogenesis and their functioning in adults in normal and pathological conditions are discussed. The influence of GnRH on the development of the immune system, on the one hand, and the influence of proinflammatory cytokines on the development of the hypothalamic-pituitary-gonadal system, on the other hand, and their functioning in adult offspring are analyzed. We have focused on the effects of GnRH on the formation and functional activity of the thymus, as the central organ of the immune system, in the perinatal period. The main mechanisms of reciprocal regulation of these systems are discussed. The reproductive health of an individual is programmed by the establishment and development of physiological systems during critical periods. Regulatory epigenetic mechanisms of development are not strictly genetically controlled. These processes are characterized by a high sensitivity to various regulatory factors, which provides possible corrections for disorders. 相似文献
3.
Matthew Thomas Ferreira Juliano Andreoli Miyake Renata Nascimento Gomes Fbio Feitoza Pollyana Bulgarelli Stevannato Andrew Silva da Cunha Fernanda de Oliveira Serachi Alexandros Theodoros Panagopoulos Alison Colquhoun 《International journal of molecular sciences》2021,22(9)
Prostaglandin E2 (PGE2) is known to increase glioblastoma (GBM) cell proliferation and migration while cyclooxygenase (COX) inhibition decreases proliferation and migration. The present study investigated the effects of COX inhibitors and PGE2 receptor antagonists on GBM cell biology. Cells were grown with inhibitors and dose response, viable cell counting, flow cytometry, cell migration, gene expression, Western blotting, and gelatin zymography studies were performed. The stimulatory effects of PGE2 and the inhibitory effects of ibuprofen (IBP) were confirmed in GBM cells. The EP2 and EP4 receptors were identified as important mediators of the actions of PGE2 in GBM cells. The concomitant inhibition of EP2 and EP4 caused a significant decrease in cell migration which was not reverted by exogenous PGE2. In T98G cells exogenous PGE2 increased latent MMP2 gelatinolytic activity. The inhibition of COX1 or COX2 caused significant alterations in MMP2 expression and gelatinolytic activity in GBM cells. These findings provide further evidence for the importance of PGE2 signalling through the EP2 and the EP4 receptor in the control of GBM cell biology. They also support the hypothesis that a relationship exists between COX1 and MMP2 in GBM cells which merits further investigation as a novel therapeutic target for drug development. 相似文献
4.
5.
6.
现场可编程门阵列(FPGA)内部资源众多,其中互连资源出现故障的概率远远高于片内其他资源,而在以往许多互连测试研究中,所生成的测试配置存在无法覆盖反馈桥接故障的难题,所以较难有测试配置实现故障列表的100%覆盖。因此通过约束桥接故障只发生在单个查找表(LUT)内的信号线上,并结合单项函数,对反馈桥接故障模型进行优化改进,从根本上解决难题;然后对优化后的反馈桥接故障设置相应的约束条件,再使用布尔可满足性理论(SAT)生成满足约束条件的测试配置。采用优化后的故障模型对ISCAS"89基准电路进行了测试配置生成实验,结果表明生成的测试向量解决了反馈桥接故障的覆盖难题,并且在实现故障列表的100%覆盖下,优化后的故障模型所需要的测试配置数最少。 相似文献
7.
为应对"三软"煤层综放沿空掘巷围岩稳定性差的问题,通过数值模拟分析、揭示"三软"煤层中锚杆、锚索载荷变化规律及其与围岩变形相互作用关系,为"三软"煤层沿空掘巷锚网支护参数优化提供理论依据,改善了巷道支护状况,降低相邻工作面间保护煤柱压煤率,提高矿井经济效益和社会效益。 相似文献
8.
9.
Jing-jie Xie Xiao-Li Zou Yan-ping Li Zhuang-Li Kang Han-jun Ma 《International Journal of Food Science & Technology》2022,57(4):2459-2466
The effects of high-pressure-modified soy 11S globulin (0.1, 200, and 400 MPa) on the gel properties, water-holding capacity, and water mobility of pork batter were investigated. The high-pressure-modified soy 11S globulin significantly increased (P < 0.05) the emulsion stability, cooking yield, hardness, springiness, chewiness, resilience, cohesiveness, the a* and b* values, and the G′ and G′′ values of pork batter at 80 °C, compared with those of 0.1 MPa-modified globulin. In contrast, the centrifugal loss and initial relaxation time of T2b, T21, and T22 significantly decreased (P < 0.05). Meanwhile, the microstructure was denser, and the voids were smaller and more uniform compared with those of 0.1 MPa-modified globulin. In addition, the sample with 11S globulin modified at 400 MPa had the best water-holding capacity, gel structure, and gel properties among the samples. Overall, the use of high-pressure-modified soy 11S globulin improved the gel properties and water-holding capacity of pork batter, especially under 400 MPa. 相似文献
10.
Machine learning algorithms have been widely used in mine fault diagnosis. The correct selection of the suitable algorithms is the key factor that affects the fault diagnosis. However, the impact of machine learning algorithms on the prediction performance of mine fault diagnosis models has not been fully evaluated. In this study, the windage alteration faults (WAFs) diagnosis models, which are based on K-nearest neighbor algorithm (KNN), multi-layer perceptron (MLP), support vector machine (SVM), and decision tree (DT), are constructed. Furthermore, the applicability of these four algorithms in the WAFs diagnosis is explored by a T-type ventilation network simulation experiment and the field empirical application research of Jinchuan No. 2 mine. The accuracy of the fault location diagnosis for the four models in both networks was 100%. In the simulation experiment, the mean absolute percentage error (MAPE) between the predicted values and the real values of the fault volume of the four models was 0.59%, 97.26%, 123.61%, and 8.78%, respectively. The MAPE for the field empirical application was 3.94%, 52.40%, 25.25%, and 7.15%, respectively. The results of the comprehensive evaluation of the fault location and fault volume diagnosis tests showed that the KNN model is the most suitable algorithm for the WAFs diagnosis, whereas the prediction performance of the DT model was the second-best. This study realizes the intelligent diagnosis of WAFs, and provides technical support for the realization of intelligent ventilation. 相似文献