Genetic Deficiency and Pharmacological Stabilization of Mast Cells Ameliorate Pressure Overload-Induced Maladaptive Right Ventricular Remodeling in Mice

Although the response of the right ventricle (RV) to the increased afterload is an important determinant of the patient outcome, very little is known about the underlying mechanisms. Mast cells have been implicated in the pathogenesis of left ventricular maladaptive remodeling and failure. However, the role of mast cells in RV remodeling remains unexplored. We subjected mast cell-deficient WBB6F1-KitW/W-v (Kit^W/Kit^W-v) mice and their mast cell-sufficient littermate controls (MC^+/+) to pulmonary artery banding (PAB). PAB led to RV dilatation, extensive myocardial fibrosis, and RV dysfunction in MC^+/+ mice. In PAB Kit^W/Kit^W-v mice, RV remodeling was characterized by minimal RV chamber dilatation and preserved RV function. We further administered to C57Bl/6J mice either placebo or cromolyn treatment starting from day 1 or 7 days after PAB surgery to test whether mast cells stabilizing drugs can prevent or reverse maladaptive RV remodeling. Both preventive and therapeutic cromolyn applications significantly attenuated RV dilatation and improved RV function. Our study establishes a previously undescribed role of mast cells in pressure overload-induced adverse RV remodeling. Mast cells may thus represent an interesting target for the development of a new therapeutic approach directed specifically at the heart.     

公民新闻与权力变移

公民新闻的诞生源于信息网络技术的推动,同时也得力于媒介接近权的付诸实践。结合国内外学者的网络社会学主要研究成果,本文着重探索和分析了媒介权力变移所呈现出来的知识化、扁平化和分散化的趋向,并分析研究了现今阶段公民新闻在媒介权力变移过程的所面临的问题。     

加工切割精度对研磨的影响

本文主要介绍了在加工基板边部时,需将控制边部质量放在首。对于边部质量控制的重要环节是切割工序,切割的精度将直接影响到研磨边部的质量,从而影响边部良品率。因此,切割精度是作为控制边部质量的第一要素。     

Pittsburgh's translocal social movement: A case of the new public water

This paper contributes to the water privatization and governance literatures by examining the case of Pittsburgh where renewed efforts of water privatization have emerged after a failed private management arrangement between the local water authority and Veolia ended abruptly in 2015. We argue that, as the water authority aims to rebuild trust in the community, resident mobilization has played a key role in hindering further privatizing arrangements and has exerted influence in defining what constitutes the “new public” water in Pittsburgh, by advocating for increased transparency and accountability in governance, infrastructure improvements and protections for low-income residents.     

浅谈加拿大魁北克省矿产资源管理制度

魁北克省是加拿大面积最大的省,其矿产资源丰富,矿产品生产在加拿大及全球占有举足轻重的地位。魁北克省自由而透明的矿产资源管理制度、鼓励商业性勘查的优惠政策、矿山复垦的高度重视和不断完善与修改的《矿业法》及其监督措施等,促进了矿产开发与环境保护。文章以魁北克省《矿业法》为重点,介绍魁北克省在矿产资源管理中的经验和优势,为我国矿产资源管理制度改革和企业走出去提供相关信息。     

高层住宅邻里交往空间构成分析

本文在强调邻里交往重要性的同时,对现在与过去在交往内容方面所存在的不同也进行了分析。认为在现代城市集合住宅中实现"促进邻里交往",其关键的问题在于必须设置相应的交往空间。     

城市基础设施项目BOT特许权合同分析

本文通过对既有BOT项目特许权合同的归纳、分析和总结,提出BOT项目特许权合同应具备的合同框架和主要内容.     

实现和分配土地开发权的公共政策——城乡规划体系的核心要义和创新方向

引入"土地开发权"概念,从公共政策的角度,提出城乡规划的核心任务,是要高效地实现和公平地分配开发权。城乡规划体系中的三大法定规划,就是从不同层面逐步明确土地开发权的:区域规划确定各地区发展权并制定区域之间开发权的转移和补偿政策,城乡总体规划确定土地使用性质并制定城乡之间开发权的转移和补偿政策,城市控制性详细规划确定土地开发强度并制定城市内部开发权转移和补偿政策。由此提出对现行城乡规划体系及其编制内容和方法等方面新的完善要求。     

施工企业项目经理的责、权、利的探讨

项目经理是施工项目责、权、利的主体。责任是实现项目经理责任制的核心；权限是确保项目经理能够承担起责任的条件和手段；利益是项目经理工作的动力。本文从以上几个方面阐述了这三者之间的关系以及如何充分发挥项目经理的聪明才智。