Genistein Inhibition of Topoisomerase II�� Expression Participated by Sp1 and Sp3 in HeLa Cell

Genistein (4′, 5, 7-trihydroxyisoflavone) is an isoflavone compound obtained from plants that has potential applications in cancer therapy. However, the molecular mechanism of the action of genistein on cancer cell apoptosis is not well known. In this study, we investigated the effect of genistein on topoisomerase II-α (Topo IIα), an important protein involved in the processes of DNA replication and cell proliferation. The results revealed that inhibition of Topo IIα expression through the regulation of Specificity protein 1 and Specificity protein 3 may be one of the reasons for genistein’s induction of HeLa cell apoptosis.     

柔性多体系统混合递推动力学建模及实时仿真研究

进一步发展了空间算子代数理论体系,采用空间算子描述了广义柔性多体系统动力学高效率建模以及实时仿真问题。根据不同类型的铰链特征(主动关节、被动关节)描述了广义柔性多体系统特征,按照两次从系统顶端到基座和一次从基座到顶端的顺序分别计算系统的广义铰接体惯量算子、系统的冗余力算子以及广义加速度和广义主动力矩,进而建立广义柔性系统O(N)阶动力学模型。采用线性多步积分算法理论解决了大型微分代数方程的数值积分算法,实现了实时动力学仿真的目的。最后通过实例结果对比验证了研究内容的正确性和高效性。     

单晶硅中磷离子注入缺陷的HREM研究

单晶硅中磷离子注入的剖面透射电镜(X-TEM)及HREM研究表明:能量为150keV,剂量为1×10~(13)cm~(-2)的磷离子注入后,在未经退火时,单晶硅表面以下1100A处可产生厚度为1000A的非晶层,非晶区与单晶区的边界为粗糙界面.在非晶区两侧,存在着大量不同类型的缺陷:{311}面缺陷和{111}堆垛层错.它们分布在不同的层区内,对于非晶区而言,形成大体对称的分布状态.接近非晶区,{111}堆垛层错密度较大,远离非晶区,{311}面缺陷密度较大,深层的完整晶体中,上述面缺陷的密度均很小.