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1.
Hiromasa Tanno Emi Kanno Suzuna Sato Yu Asao Mizuki Shimono Shiho Kurosaka Yukari Oikawa Shinyo Ishi Miki Shoji Ko Sato Jun Kasamatsu Tomomitsu Miyasaka Hideki Yamamoto Keiko Ishii Yoshimichi Imai Masahiro Tachi Kazuyoshi Kawakami 《International journal of molecular sciences》2021,22(8)
Chronic infections are considered one of the most severe problems in skin wounds, and bacteria are present in over 90% of chronic wounds. Pseudomonas aeruginosa is frequently isolated from chronic wounds and is thought to be a cause of delayed wound healing. Invariant natural killer T (iNKT) cells, unique lymphocytes with a potent regulatory ability in various inflammatory responses, accelerate the wound healing process. In the present study, we investigated the contribution of iNKT cells in the host defense against P. aeruginosa inoculation at the wound sites. We analyzed the re-epithelialization, bacterial load, accumulation of leukocytes, and production of cytokines and antimicrobial peptides. In iNKT cell–deficient (Jα18KO) mice, re-epithelialization was significantly decreased, and the number of live colonies was significantly increased, when compared with those in wild-type (WT) mice on day 7. IL-17A, and IL-22 production was significantly lower in Jα18KO mice than in WT mice on day 5. Furthermore, the administration of α-galactosylceramide (α-GalCer), a specific activator of iNKT cells, led to enhanced host protection, as shown by reduced bacterial load, and to increased production of IL-22, IL-23, and S100A9 compared that of with WT mice. These results suggest that iNKT cells promote P. aeruginosa clearance during skin wound healing. 相似文献
2.
Jun Ogata Kentaro Hirao Kenya Nishioka Arisa Hayashida Yuanzhe Li Hiroyo Yoshino Soichiro Shimizu Nobutaka Hattori Yuzuru Imai 《International journal of molecular sciences》2021,22(7)
Leucine-rich repeat kinase 2 (LRRK2) is a major causative gene of late-onset familial Parkinson’s disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of LRRK2 associated with PD exhibit increased kinase activity. We herein report a novel LRRK2 variant—p.G2294R—located in the WD40 domain, detected through targeted gene-panel screening in a patient with familial PD. The proband showed late-onset Parkinsonism with dysautonomia and a good response to levodopa, without cognitive decline or psychosis. Cultured cell experiments revealed that p.G2294R is highly destabilized at the protein level. The LRRK2 p.G2294R protein expression was upregulated in the patient’s peripheral blood lymphocytes. However, macrophages differentiated from the same peripheral blood showed decreased LRRK2 protein levels. Moreover, our experiment indicated reduced phagocytic activity in the pathogenic yeasts and α-synuclein fibrils. This PD case presents an example wherein the decrease in LRRK2 activity did not act in a neuroprotective manner. Further investigations are needed in order to elucidate the relationship between LRRK2 expression in the central nervous system and the pathogenesis caused by altered LRRK2 activity. 相似文献
3.
Akio Ohta Faisal Hossain Hitoshi Asakawa Tsuyoshi Asakawa 《Journal of surfactants and detergents》2020,23(1):99-108
Cysteine and methionine, two sulfur-containing amino acids (AA), were introduced in their surfactant forms as potential antioxidants. The antioxidative (AOX) properties of lauroyl methionine (C12-Met) and lauroyl cysteine (C12-Cys) was investigated by means of the oxygen radical absorbance capacity assay. Both the surfactants exhibited excellent AOX behavior at the premicellar state and micellar medium. The AOX behavior was found to be comparable for both the surfactants at their premicellar states. However, in micellar medium, C12-Met showed better AOX property than C12-Cys. The AOX power of the surfactants was compared with other previously developed AA-type surfactants. The order of the AOX power was found to be: C12-tryptophan > C12-tyrosine ≈ C12-methionine ≈ C12-cysteine > C12-histidine at the premicellar state and C12-tryptophan > C12-tyrosine > C12-methionine > C12-cysteine > C12-histidine at the micellar state. C12-Cys displayed lower AOX property in micellar medium due to its dimer formation tendency. Based on the HPLC and UPLC-Q-TOF-MS analysis, the dimer formation of C12-Cys was found to be accelerated due to the micellar environment and results into negative synergistic effect on other aromatic AA-type surfactants. However, the presence of C12-His in the micellar solution of C12-Cys resulted no synergistic effect due to stronger H-bonding between the surfactants and resulting less dimer formation. 相似文献
4.
Hideo Yamauchi Junichi Ikejiri Fumio Sato Hiroyuki Oshita Tsuyoshi Honma Takayuki Komatsu 《Journal of the American Ceramic Society》2019,102(11):6658-6667
In recent years, the expansion of demand for lithium ion batteries has resulted in soaring prices of the constituent resources. From the viewpoint of safety, studies on all-solid-state batteries are actively being carried out. In this study, we succeeded in driving all-solid-state batteries derived from nontoxic oxide glasses at room temperature without requiring scarce resources such as lithium and cobalt. The main structure of the ceramic batteries with a simple structure in which Na2FeP2O7 crystallized glass and β″-alumina solid solution are joined by pressureless cofiring at 550°C. During the crystallization of Na2O-Fe2O3-P2O5 glass, fusion with the β″-alumina solid solution is achieved. Reversible charge and discharge of 80 mAh/g were achieved at room temperature. It is not necessary to apply pressure during cell preparation or the use of the batteries. Furthermore, the strong junction at the cathode and electrolyte interface does not peel off during charge and discharge over a long period of 623 cycles. Ex situ X-ray photoelectron spectroscopy revealed partial Fe4+ induction and a reversible charge and discharge reaction even after overcharging to 9 V. It was demonstrated that Na2FeP2O7 is very stable against overcharging to 9 V. 相似文献
5.
Kazuyoshi Uruga Takeshi Tsukada Tsuyoshi Usami 《Journal of Nuclear Science and Technology》2020,57(4):433-443
ABSTRACTIn order to develop a glass production method that inhibits formation of the Mo-bearing secondary phase, the so-called yellow phase (YP), and also to clarify its formation behavior, vitrification tests using a small-scale liquid-fed ceramic melter (LFCM) were conducted. Chemically simulated PUREX liquid waste containing Na, Mo and other fission elements was fed into a molten glass pool in the melter together with several sizes of feed glass. When the glass beads with a diameter of around 2 mm were fed, some YP was contained in the vitrified glass products at 25 wt% waste loading. While, almost no YP was detected in the glass products when glass powder with a diameter of less than 63 μm was used. The microscopic analysis of the cold-cap samples revealed that powderization of the feed glass contributed to the facilitation of Na dissolution to the feed glass in the cold-cap. This quick intake of Na to the feed glass prevented the formation of liquid Na2MoO4 aggregation and provided homogeneous Mo dispersion in the cold-cap with forms of alkali earth and/or rare earth molybdates. The homogeneous dispersion of Mo resulted in the fast and complete dissolution of Mo in the glass melt. 相似文献
6.
Ninrutsirikun Unhawa Imai Hideyuki Watanapa Bunthit Arpnikanondt Chonlameth 《Wireless Personal Communications》2020,115(4):2897-2916
Wireless Personal Communications - Studying computer programming requires not only an understanding of theories and concepts, but also coding pragmatism. Success in studying or conducting such a... 相似文献
7.
Shahira Said Aly Tsuyoshi Imai Mohamed Salah Hassouna Diem-Mai Kim Nguyen Takaya Higuchi Ariyo Kanno Koichi Yamamoto Rinji Akada Masahiko Sekine 《International Journal of Hydrogen Energy》2018,43(10):5300-5313
The ability of Clostridium butyricum RAK25832 to use casamino acids as a nitrogen source was investigated. Strain RAK25832 showed the capacity to utilize different types of carbon sources. With glucose as a carbon source (10 g/L), the preferred final concentration of casamino acids was 26.67 g/L, with a cumulative hydrogen production, production rate, and yield of 2505 mL H2/L, 160 mL/h, and 1.81 mol H2/mol glucose, respectively. Eighteen metal elements were screened to identify the most important metals for biohydrogen production, and four elements were optimized. The optimal medium composition was MgCl2·6H2O (0.1 g/L), K2HPO4·3H2O (6.67 g/L), NaHCO3 (2.6 g/L), and FeCl2·4H2O (0.002 g/L). Vitamin supplementation of the medium showed no significant effect on hydrogen production. Under the optimized conditions, cumulative hydrogen production reached 3074 mL H2/L. This is the first study to demonstrate the use of casamino acids as a nitrogen source by C. butyricum. 相似文献
8.
9.
Koutaki Gou Ando Sakino Shirai Keiichiro Kishigami Tsuyoshi 《International Journal of Computer Vision》2022,130(9):2286-2304
International Journal of Computer Vision - In April 2016, a massive earthquake with a magnitude of 7.3 struck Kumamoto region, Japan, causing major devastation. One of the structures that were... 相似文献
10.
A consistent grayscale‐free topology optimization method using the level‐set method and zero‐level boundary tracking mesh 下载免费PDF全文
Shintaro Yamasaki Atsushi Kawamoto Tsuyoshi Nomura Kikuo Fujita 《International journal for numerical methods in engineering》2015,101(10):744-773
This paper proposes a level‐set based topology optimization method incorporating a boundary tracking mesh generating method and nonlinear programming. Because the boundary tracking mesh is always conformed to the structural boundary, good approximation to the boundary is maintained during optimization; therefore, structural design problems are solved completely without grayscale material. Previously, we introduced the boundary tracking mesh generating method into level‐set based topology optimization and updated the design variables by solving the level‐set equation. In order to adapt our previous method to general structural optimization frameworks, the incorporation of the method with nonlinear programming is investigated in this paper. To successfully incorporate nonlinear programming, the optimization problem is regularized using a double‐well potential. Furthermore, the sensitivities with respect to the design variables are strictly derived to maintain consistency in mathematical programming. We expect the investigation to open up a new class of grayscale‐free topology optimization. The usefulness of the proposed method is demonstrated using several numerical examples targeting two‐dimensional compliant mechanism and metallic waveguide design problems. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献