纳米药物非临床药代动力学的研究策略及关注要点

随着纳米技术的迅速发展，纳米药物的研发已成为目前药物创新的发展方向之一。纳米药物具有基于纳米结构的尺度效应，其药代动力学特征与普通药物相比存在明显差异，其药代动力学研究与普通药物相比也有其特殊性。本文着重探讨纳米药物的非临床药代动力学的研究策略及关注要点，包括受试物、体内/外试验、生物样本分析、数据评价分析等，期望为研发者提供参考。     

Modeling of Ignition and Combustion of a Coflowing Hydrogen Jet in a Supersonic Air Flow

Combustion, Explosion, and Shock Waves - Results of a numerical study of mixing, ignition, and combustion of a cold hydrogen jet propagating along the lower wall of a channel parallel to a...     

智慧标识网络服务机理研究进展及安全性分析

随着互联网规模的不断扩大以及应用场景的多元化,传统网络无法很好地满足新业务的动态多样化需求,因此国内外对未来网络展开了深入研究.本文首先介绍了未来互联网体系架构的研究现状.其次,介绍了具备"三层、两域"特征的智慧标识网络(Smart Identifier NETwork,SINET)体系架构,然后重点阐述了SINET服务机理在服务的命名与解析、路由机制、服务缓存、移动性、传输控制机制、可扩展性、绿色节能等关键技术方面取得的研究进展,并进一步详细分析了SINET服务机理的安全性.最后总结了SINET面临的挑战,对SINET服务机理在大规模场景部署中可能存在的问题做出讨论.     

Low light enhancement algorithm for color images using intuitionistic fuzzy sets with histogram equalization

Multimedia Tools and Applications - In this work, a new fuzzy logic-based algorithm is proposed for the enhancement of low light color images. A generalization of a fuzzy set known as an...     

Effective capacity maximization of two-way full-duplex and half-duplex relays with finite block length packets transmission

Wireless Networks - In order to satisfy the delay requirements of telecommunication systems, in this paper, we present a cooperative network with the short packet transmission in the Rayleigh...     

Deep transfer modeling for classification of Maize Plant Leaf Disease

Multimedia Tools and Applications - Currently, Deep Learning is playing an influential role for Image analysis and object classification. Maize’s diseases reduce production that subsequently...     

IRS辅助的SWIPT系统中基于能效优先的波束成形设计与优化

以智能反射面(intelligent reflecting surface,IRS)辅助的无线携能通信(simultaneous wireless information and power transfer,SWIPT)系统为背景,研究了该系统中基于能效优先的多天线发送端有源波束成形与IRS无源波束成形联合设计与优化方法。以最大化接收端的最小能效为优化目标,构造在发送端功率、接收端能量阈值、IRS相移等多约束下的非线性优化问题,用交替方向乘子法(alternating direction method of multipliers,ADMM)求解。采用Dinkelbach算法转化目标函数,通过奇异值分解(singular value decomposition,SVD)和半定松弛(semi-definite relaxation,SDR)得到发送端有源波束成形向量。采用SDR得到IRS相移矩阵与反射波束成形向量。结果表明,该系统显著降低了系统能量收集(energy harvesting,EH)接收端的能量阈值。当系统总电路功耗为?15 dBm时,所提方案的用户能效为300 KB/J。当IRS反射阵源数与发送天线数均为最大值时,系统可达最大能效。     

Application of big data language recognition technology and GPU parallel computing in English teaching visualization system

International Journal of Speech Technology - With the development of multimedia technology and network technology applications, it is possible to implement online teaching systems in schools. This...