全文获取类型
收费全文 | 96925篇 |
免费 | 2172篇 |
国内免费 | 1040篇 |
专业分类
电工技术 | 1567篇 |
技术理论 | 1篇 |
综合类 | 3527篇 |
化学工业 | 13801篇 |
金属工艺 | 5390篇 |
机械仪表 | 3728篇 |
建筑科学 | 2997篇 |
矿业工程 | 870篇 |
能源动力 | 1484篇 |
轻工业 | 5705篇 |
水利工程 | 1538篇 |
石油天然气 | 808篇 |
武器工业 | 95篇 |
无线电 | 10435篇 |
一般工业技术 | 17662篇 |
冶金工业 | 3112篇 |
原子能技术 | 362篇 |
自动化技术 | 27055篇 |
出版年
2024年 | 57篇 |
2023年 | 207篇 |
2022年 | 510篇 |
2021年 | 717篇 |
2020年 | 527篇 |
2019年 | 389篇 |
2018年 | 14855篇 |
2017年 | 13868篇 |
2016年 | 10380篇 |
2015年 | 1329篇 |
2014年 | 1154篇 |
2013年 | 1301篇 |
2012年 | 4366篇 |
2011年 | 10683篇 |
2010年 | 9370篇 |
2009年 | 6648篇 |
2008年 | 7762篇 |
2007年 | 8641篇 |
2006年 | 830篇 |
2005年 | 1621篇 |
2004年 | 1367篇 |
2003年 | 1319篇 |
2002年 | 653篇 |
2001年 | 170篇 |
2000年 | 248篇 |
1999年 | 110篇 |
1998年 | 96篇 |
1997年 | 74篇 |
1996年 | 70篇 |
1995年 | 38篇 |
1994年 | 30篇 |
1993年 | 24篇 |
1992年 | 25篇 |
1991年 | 32篇 |
1988年 | 15篇 |
1969年 | 24篇 |
1968年 | 43篇 |
1967年 | 33篇 |
1966年 | 42篇 |
1965年 | 44篇 |
1963年 | 28篇 |
1962年 | 22篇 |
1961年 | 18篇 |
1960年 | 30篇 |
1959年 | 36篇 |
1958年 | 37篇 |
1957年 | 36篇 |
1956年 | 34篇 |
1955年 | 63篇 |
1954年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
Shanshan Zhuang Wenxiong Zheng Yunong Na Naiyi Chen Fan Gong Bingxuan Huang Stephen Brennan Charles Congyi Liu Jian Cheng Lukai Ma Huifan Liu 《International Journal of Food Science & Technology》2022,57(2):1093-1103
The β-Carotene (BC), an important precursor of vitamin A (VA), possesses antioxidant activity but is fat-soluble and has low bioavailability. In previous in-vitro assays evaluating antioxidant and 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) free radical scavenging, both BC and VA showed a strong ability to scavenge radicals and protected cells from oxidative stress. Here, we used artificially simulated gastrointestinal digestion and Caco-2 cell absorption models to evaluate the bioavailability of the BC during gastrointestinal digestion and absorption using high-performance liquid chromatography (HPLC) analysis. We observed high absorptive and transfer rates of BC and detected retinol metabolites (Vitamin A). Therefore, BC can be detected in the acidic gastrointestinal environment using HPLC. Optimised method provided better separation of BC and VA in the column, improving the accuracy of the test results. 相似文献
3.
4.
文章通过对黑龙江省高效节水现状,存在问题的分析,结合黑龙江省高效节水发展的支撑能力,阐述黑龙江省节水增粮目标、任务及总体布局,为黑龙江省2012—2015年节水增粮实施提供依据。 相似文献
5.
6.
Mobile software applications have to cope with a particular environment that involves small size, limited resources, high autonomy requirements, competitive business models and many other challenges. To provide development guidelines that respond to these needs, several practices have been introduced; however, it is not clear how these guidelines may contribute to solve the issues present in the mobile domain. Furthermore, the rapid evolution of the mobile ecosystem challenges many of the premises upon which the proposed practices were designed. In this paper, we present a survey of the literature on software assurance practices for mobile applications, with the objective of describing them and assessing their contribution and success. We identified, organized and reviewed a body of research that spans in three levels: software development processes, software product assurance practices, and software implementation practices. By carrying out this literature survey, we reviewed the different approaches that researchers on Software Engineering have provided to address the needs that raise in the mobile software development arena. Moreover, we review the evolution of these practices, identifying how the constant changes and modernization of the mobile execution environment has impacted the methods proposed in the literature. Finally, we introduced discussion on the application of these practices in a real productive setting, opening an area for further research that may determine if practitioners have followed the proposed assurance paradigms. 相似文献
7.
This paper presents an integrated passive damping approach in hybrid metal-CFRP parts for structural applications. In this concept a viscoelastic material is embedded in the joint zone of the hybrid component. To examine the connection strength single-lap-joint specimens were produced and tested and the influence of the used material combinations, different surface structures, and different process parameters i.e. the moment of cross-linking were evaluated. Afterwards, the metal-CFRP hybrids were tested in quasi-static tests to assess their connection strength and failure behaviour. Dynamic cyclic tensile tests with step-wise increased loading conditions were performed to determine the specimens damping behaviour and to estimate their fatigue performance. Finally, these results are compared to a state of the art metal-CFRP hybrid with rivets connecting both materials. 相似文献
8.
In this paper, we consider the classical finite mixture model, which is an effective tool for modeling lifetime distributions for random samples from heterogeneous populations. We discuss new results on stochastic comparison for two finite mixtures when each of them is drawn from one of the following semiparametric families, i.e., proportional hazards, accelerated lifetime and proportional reversed hazards. 相似文献
9.
10.