共查询到20条相似文献,搜索用时 734 毫秒
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以NBS为溴源,3-特戊酰氧基-5β,6β-环氧-7β-羟基-15β,16β-二亚甲基-孕甾-17-酮为原料,在三苯基膦催化剂的作用下合成了屈螺酮的关键中间体3-特戊酰氧基-5β,6β-环氧-7α-溴-15β,16β-二亚甲基-孕甾-17-酮,考察了NBS的用量、催化剂的用量、反应温度、反应时间对3-特戊酰氧基-5β,6β-环氧-7α-溴-15β,16β-二亚甲基-孕甾-17-酮收率的影响。实验结果表明,最佳投料条件下目标物的质量收率为89.5%。该方法条件温和,操作简单,易于实现工业化生产。 相似文献
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以4-甲基苯并呋咱为起始原料,经N-溴代丁二酰亚胺(NBS)溴化、Sommelet反应制得4-甲酰基苯并呋咱。重点考察了溴化剂和引发剂对溴化反应以及原料配比、反应温度、反应时间等对Sommelet反应过程的影响。优化的工艺条件为:NBS为溴化剂、过氧化苯甲酰(BPO)为与光照引发剂,温度为62℃,时间为5 h,4-溴甲基苯并呋咱收率为86.8%;n(4-溴甲基苯并呋咱)∶n(乌洛托品)=1∶1.2,醋酸为催化剂及反应溶剂,成盐反应60℃反应2 h,酸解80℃反应4 h,产品收率达78.4%。 相似文献
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A. G. Gopala Krishna 《Journal of the American Oil Chemists' Society》1992,69(12):1257-1259
The color of bleached rice bran oil can be improved by silica gel treatment of the oil miscella before or after dewaxing.
A silica gel/oil/solvent ratio of 1:5:5 (wt/wt/vol) is suitable. Silica gel treatment can be carried out either by column
percolation or by merely shaking the miscella with the gel followed by decantation. However, column percolation is more efficient,
with 30–72% color reductionvs. 19–36% reduction for shaking and decanting. 相似文献
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以噻吩-2-甲醛为原料,与磷酰基乙酸三乙酯在氢化钠存在下反应制备3-(2-噻吩)丙烯酸乙酯,后通过水解制备3-(2-噻吩)丙烯酸,总收率78.5%,纯度98.6%,可制备121 g每批。考察了原料滴加速度、物料摩尔比、溶剂用量、柱层析硅胶用量对化合物2合成的影响,确定了最佳条件为:滴加速度8 m L/min、噻吩-2-甲醛与膦酰基乙酸三乙酯摩尔比为1:1.2,溶剂1.6 L,柱层析用硅胶与粗产物重量比为1:15,该步反应收率92.3%,水解后产物经重结晶获得纯品,收率85%。产物结构通过质谱、核磁鉴定正确。 相似文献
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A method has been developed for visible and UV spectrophotometry of lipid monolayers after preadsorption on silica gel from
solution in hydrocarbon solvents. Lipid-coated silica gel is made optically transparent in the desired spectral region by
slurrying with an inert solvent mixture. Reproducible gels with nearly the same refractive index as the solvent are achieved
by careful choice of mixed solvents and carefully timed settling periods. The gel is pipetted into a silica cuvette of 1 cm
light path, and a 9 mm silica spacer bar is inserted between Teflon guide strips. Appropriate choice of solvent mixtures (mainly
spectral grade cyclohexane and cyclooctane) permits quantitation of spectra down to 2250 Angstrom units, using a silica gel
reference cell. Lipid elution from the monolayer into the solvent is usually less than 1% at the dry-mixing dilutions used.
Spectra of known unsaturated carbonyl compounds adsorbed on silica show red shifts as great as 240 Angstrom units, while blue
shifts as great as 100 Angstrom units are observed for tocopherol derivatives with an intact aromatic ring. Very small shifts
are observed for polyenes. The extent and direction of the shifts are indicative of adsorption and its orientation and are
useful in the preliminary determination of the class of an unknown compound. The silica slurry spectra of the important tocopherol
oxidation products, the quinone, dimer and trimer, have been examined. Peak wavelength shifts are consistent with structures
elsewhere proposed for these compounds. 相似文献
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硅胶的制备及应用现状 总被引:1,自引:0,他引:1
硅胶不溶于水和任何溶剂,无毒无味,化学性质稳定,除强碱、氢氟酸外不与任何物质发生反应。根据其孔径的大小分为:大孔硅胶、粗孔硅胶、B型硅胶、细孔硅胶。由于孔隙结构的不同,因此它们的吸附性能各有特点。硅胶是一种高活性的吸附材料,通常以硅酸钠和硫酸为原料制备,文中介绍了各种硅胶的生产工艺,论述了硅胶的应用现状。 相似文献
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Setiyo Gunawan Suryadi Ismadji Yi-Hsu Ju 《Journal of the Chinese Institute of Chemical Engineers》2008,39(6):625-633
Liquid–solid chromatography (LSC) is the oldest of the various liquid chromatography methods. Despite the fact that high-performance liquid chromatography (HPLC) operation leads to better separation and analysis, classical column chromatography and thin-layer chromatography (TLC) are still widely practiced because of their convenience. In this study, a modified silica gel column chromatography was designed with the objective of reducing the amount of solvent required to achieve the same degree of separation as the classical silica gel column chromatography. The separation of squalene and fatty acid steryl esters (FASEs) from non-polar lipid fraction (NPLF) of soybean oil deodorizer distillate (SODD) was employed as a model system to test the effectiveness of this new design. Modified silica gel column chromatography process is feasible from economic point of view compare to classical silica gel column chromatography because it significantly reduces the amount of solvent and time required to achieve the same degree of separation. By employing modified silica gel column chromatography to obtain the squalene-rich fraction, the mobile phase volume and elution time required as fractions of those needed in classical silica gel column chromatography are 1/73 and 1/18, respectively. To obtain the FASEs-rich fraction, the corresponding mobile phase volume and elution time are 1/221 and 1/23, respectively of those needed in classical silica gel column chromatography. 相似文献
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采用柱层析法分离羊毛脂中的胆固醇,以胆固醇与杂质羊毛甾醇的分离度为判定依据来筛选吸附剂及优化层析工艺,同时对吸附剂进行了再生考察。实验表明,当以200~300目粗孔硅胶为吸附剂、丙酮/正己烷混合溶剂(体积比4∶96)为流动相、35 ℃ 下胆固醇上载量为2.4%(质量分数)时,胆固醇的分离效果较好,所得胆固醇含量可达84.36%,收率为85.67%。另外选用丙酮/正己烷混合溶剂(体积比50∶50)对吸附剂进行再生处理,硅胶经7次使用再生循环,分离效果未降低。 相似文献
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C. Lekakou I. Kontodimopoulos A.K. Murugesh Y.L. Chen D.A. Jesson J.F. Watts P.A. Smith 《Polymer Engineering and Science》2008,48(2):216-222
The aim of this study is to investigate the processability of silica‐thermoset polymer matrix nanocomposites in terms of dispersion of silica nanoparticles and their effect on curing. Two thermosetting resins were considered, an epoxy and a polyester resin, with 5% silica, although 1% silica was also used in preliminary studies in the polyester system. Various combinations of mechanical mixing and sonication were investigated for the dispersion of silica nanoparticles under different processing conditions and times in solvent‐free and solvent‐containing systems. It was found that the best dispersion route involved a solvent‐aided dispersion technique. Consequently, different procedures for the solvent removal were investigated. Optical microscopy and SEM were used to characterize the resulting nanocomposites. DSC and rheological DMTA tests demonstrated that the silica nanoparticles shorten the gel time and promote curing in these thermosetting systems. POLYM. ENG. SCI., 2008. © 2007 Society of Plastics Engineers 相似文献
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R. Amarowicz M. Karama B. Rudnicka E. Ciska 《European Journal of Lipid Science and Technology》1995,97(9):330-333
Glucopyranosyl sinapate was obtained from rapeseeds using column chromatography on Sephadex LH-20 and RP-18 semipreparative HPLC. TLC analysis of this compound, sinapic acid and phenolic compounds fractions from column chromatography were conducted on plates coated with silica gel (standard and HPTLC), with cellulose and on RP-TLC plates. Eleven various solvent systems were applied to develop chromatograms. HPTL plates were found more efficient than those coated with standard silica gel. Compared to the latter cellulose ensured worse results of TLC analysis. The best developing system for plates coated with silica gel was benzene-methanol-acetic acid (90:16:8). Separation of the compounds analysed using RP-TLC depended on octadodecylsilanization degree of silica gel on TLC plate. 相似文献