高稳高效海上风电安装平台关键制造技术研究

海上风电作为可再生清洁能源之一,受到世界各国的高度重视与大力发展。我国将海上风电提升至解决能源危机、减缓气候变化、调整能源结构的国家战略高度,到2030年我国单位国内生产总值二氧化碳排放将比2005年下降65%以上,非化石能源占一次能源消费比重将达到25%左右。安装平台不足将是我国海上风电场无法如期建成投产的主要障碍。对自升自航式海上风电安装平台系列高端装备及其设计制造的三大技术难题——腿站立作业易“失稳”、大平台大跨距大倾覆力矩自升易“失控”、高空吊装巨型叶片逾百螺栓精准定位易“失准”,以及焊缝缺陷修复和局部裂纹损伤的激光锻造修复再制造进行了介绍,研制的具有不同规格的系列装备在中国、英国、丹麦、德国等国家的著名海上风电场建设应用情况良好。     

圆堆取料机料耙变形的改造措施

我公司Φ60 m圆堆取料机取料作业依靠主梁行走机构的圆周运动以及主梁一侧料耙的往复运动合成动作，完成石灰石的取料作业。随着使用年限的增加，料耙下部两滚轮开始出现轴承损坏故障，初期1~2月损坏一次，后期达到每周损坏1~2次，又因滚轮及其备件采购周期长，修复难度大，在修复过程中只能靠装载机上料，不仅影响生产，而且极易损伤皮带输送机。     

Matrix Manipulation of Directly-Synthesized PbS Quantum Dot Inks Enabled by Coordination Engineering

The direct-synthesis of conductive PbS quantum dot (QD) ink is facile, scalable, and low-cost, boosting the future commercialization of optoelectronics based on colloidal QDs. However, manipulating the QD matrix structures still is a challenge, which limits the corresponding QD solar cell performance. Here, for the first time a coordination-engineering strategy to finely adjust the matrix thickness around the QDs is presented, in which halogen salts are introduced into the reaction to convert the excessive insulating lead iodide into soluble iodoplumbate species. As a result, the obtained QD film exhibits shrunk insulating shells, leading to higher charge carrier transport and superior surface passivation compared to the control devices. A significantly improved power-conversion efficiency from 10.52% to 12.12% can be achieved after the matrix engineering. Therefore, the work shows high significance in promoting the practical application of directly synthesized PbS QD inks in large-area low-cost optoelectronic devices.     

High-Performance Solution-Processed Nondoped Circularly Polarized OLEDs with Chiral Triptycene Scaffold-Based TADF Emitters Realizing Over 20% External Quantum Efficiency

Recently, circularly polarized organic light-emitting diodes (CP-OLEDs) fabricated with thermally activated delayed fluorescence (TADF) emitters are developed rapidly. However, most devices are fabricated by vacuum deposition technology, and developing efficient solution-processed CP-OLEDs, especially nondoped devices, is still a challenge. Herein, a pair of triptycene-based enantiomers, (S,S)-/(R,R)-TpAc-TRZ, are synthesized. The novel chiral triptycene scaffold of enantiomers avoids their intermolecular π–π stacking, which is conducive to their aggregation-induced emission characteristics and high photoluminescence quantum yield of 85% in the solid state. Moreover, the triptycene-based enantiomers exhibit efficient TADF activities with a small singlet-triplet energy gap (ΔE_ST) of 0.03 eV and delayed fluorescence lifetime of 1.1 µs, as well as intense circularly polarized luminescence with dissymmetry factors (|g_PL|) of about 1.9 × 10⁻³. The solution-processed nondoped CP-OLEDs based on (S,S)-/(R,R)-TpAc-TRZ not only display obvious circularly polarized electroluminescence signals with g_EL values of +1.5 × 10⁻³ and −2.0 × 10⁻³, respectively, but also achieve high efficiencies with external quantum, current, and power efficiency up to 25.5%, 88.6 cd A⁻¹, and 95.9 lm W⁻¹, respectively.     

Performance analysis of bit error rate of data link system under pulse LFM interference in time-varying rayleigh channel

Wireless Networks - In such mobile platforms as ships and aircraft, the detection and reconnaissance devices are near to the communication facilities. When working at the same time, they will...     

电磁脉冲辐射波模拟器双锥-平面线栅天线场分布规律

双锥-平面线栅结构的水平极化辐射波天线对辐射场半宽影响较小且架设方便、易于维护，掌握该型天线场分布规律是确定模拟器场均匀区、开展电磁脉冲效应实验的前提。利用天线理论研究双锥-平面线栅天线的场分布规律，结合数值模拟和实际天线试验对理论分析结果进行验证。结果表明：在天线结构和激励电压确定的条件下，双锥中心正下方辐射电场极化分量仅与测点到源的距离相关，二者呈反比；Oxz平面内以双锥中心为圆心的圆弧上任意一点辐射电场极化分量的幅值相等，并在同一时刻达到峰值；Oxz平面内同一水平线上的测点总辐射场幅值相等，方向沿测点所在圆弧的切线方向；各辐射场分量关于Oxz平面和Oyz平面对称分布；对于实际模拟器，地面反射会使辐射场波形下降沿陡降，导致地面附近辐射场半宽变小；线栅极板会影响附近的场分布，且极板外侧4个角点处的反射相对较强，其他位置辐射场分布与理论分析一致。     

Targeted editing of intronic-splicing silencer enhancement of SMN2 Exon 7 inclusion by CRISPR/Case 9

Spinal muscular atrophy (SMA) is an autosomal recessive hereditary neuromuscular disease. Exon 7 and 8 of survival of motor neuron 1 (SMN1) gene or only exon 7 homology deletion leads to the failure to produce a full-length SMN gene. The copy number of SMN2 gene with high homology of SMN1 affects the degree of disease and was the target gene for targeting therapy, in which splicing silencer in intron 7 was the key to suppress the inclusion of exon 7. In this study, we projected to use CRISPR/Case 9 for the targeted editing of intronic-splicing silencer (ISS) sequence to promote the inclusion of SMN2 exon 7 and increase the production of SMN2 full-length (FL) gene expression. It happens that there was a protospacer adjacent motif (PAM) at one end of the ISS sequence according to the design of sgRNA. The recombinant vector of sgRNA HSMN2 CRISPR/Case 9 was constructed and transfected into HEK293 cells. Sequencing results showed that the ISS sequence could be edited accurately and targeting in the predicted direction, in which deleting small fragments, inserting small amounts and mutation. Quantitative analysis of RT-PCR products by restriction enzyme of DdeI digestion showed that the FL of SMN2 increased by 8% (P < 0.05). In the primary cultured chondrocytes of SMA mice, in which sgRNA HSMN2 CRISPR/Case9 recombinant vector transfection could increase the SMN2 FL gene by 23% (P < 0.05) and significantly improve SMN protein levels (P < 0.05). CRISPR/Case 9 is an effective tool for gene editing and therapy of hereditary diseases, but it is rarely reported in the treatment of SMA diseases. This study shows that CRISPR/Case 9 was first used for the precision target of ISS sequence editing, which can effectively promote the production of SMN2 FL gene expressions, in which there was an important clinical reference value.     

HPLC法测定伐地昔布的有关物质

建立高效液相色谱法检测伐地昔布的有关物质.采用α-酸性糖蛋白键合硅胶的手性色谱柱,以乙腈-醋酸铵缓冲液(0.01 mol/L,pH4.0)作为流动相进行梯度洗脱,检测波长215 nm.伐地昔布与5个已知杂质均可达到基线分离,在各自浓度范围内线性关系良好,平均回收率95.13％～99.77％,RSD1.10％～1.77％,检测限0.017 9～0.060 1 μg/mL,定量限0.059 7～0.200 0 μg/mL.方法专属性强,准确度好,灵敏度高,可为伐地昔布的质量控制及后续分离提纯和帕瑞昔布的质量控制提供指导.