基于网络公益传播的食品包装设计思路

在梳理公益包装概念发展的基础上,以公益包装的商业实践为案例,分析目前食品包装参与公益的优势、现状和问题,进而提出基于网络公益传播的食品包装设计思路,指出食品公益包装要遵循公益性、简便性、交互性和传播性等设计原则,通过整合新媒体、新材料、新技术和新场景,推动公益包装设计持续创新,促进公益包装更好地服务于企业公益传播,以实现商业利益和社会效益的共赢。     

液相色谱-串联质谱技术在临床检验中的应用研究进展

液相色谱-串联质谱（LC-MS/MS）技术具有高灵敏度、高特异性、高分辨率和高效率的优点。近年来随着仪器灵敏度的提高，LC-MS/MS在常规临床检验中显示出极大的潜力，并在疾病早期预防和诊断中发挥着不可替代的作用。本文对LC-MS/MS在新生儿疾病筛查、维生素D检测、内分泌激素检测、肽类和蛋白质定量分析等临床检验方面的研究进展进行综述，并讨论了未来面临的挑战。     

Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model

This study investigated the inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products (fAGEs) formation in a bovine serum albumin (BSA)–fructose model. Model systems of BSA and fructose were prepared, and curcumin or piperine was added. fAGEs and BSA oxidation product (dityrosine, kynurenine and N'-formylkynurenine) contents were determined. The results showed that fAGEs content decreased with increasing concentration of curcumin and piperine (P < 0.05). Addition of curcumin and piperine at 160 µg mL⁻¹ could inhibit fluorescent AGEs by 100% and 93% respectively. Dityrosine and N'-formylkynurenine contents decreased as curcumin and piperine concentration increased (P < 0.05). Furthermore, the result of principal component analysis indicated that curcumin and piperine markedly impeded BSA oxidation, resulting in a lower level of fAGEs in model systems. Therefore, adding curcumin and piperine may facilitate reduced fAGEs levels in BSA–fructose model.     

纳米药物非临床药代动力学的研究策略及关注要点

随着纳米技术的迅速发展，纳米药物的研发已成为目前药物创新的发展方向之一。纳米药物具有基于纳米结构的尺度效应，其药代动力学特征与普通药物相比存在明显差异，其药代动力学研究与普通药物相比也有其特殊性。本文着重探讨纳米药物的非临床药代动力学的研究策略及关注要点，包括受试物、体内/外试验、生物样本分析、数据评价分析等，期望为研发者提供参考。     

直通链路技术的发展与展望

直通链路技术己广泛应用于车联网场景。对于直通链路技术的潜在技术方向给出可行的建议，包括传统直通链路技术的增强方向，如载波聚合、使用非授权频谱等；侧行链路对于中继场景的应用扩展，包括终端到终端之间的中继，以及中继的多链接场景；在高精度定位场景使用直通链路技术。并且，给出直通链路技术与各种新技术的融合应用，如智能反射面与区块链技术，从而解决直通链路技术自身的缺陷。     

三维石墨烯-碳纳米管/水泥净浆的压敏性能

为了探索三维石墨烯-碳纳米管(G-CNTs)/水泥净浆的压敏性能,采用四电极法研究了荷载作用下GCNTs/水泥净浆的电阻率变化,并分析不同G-CNTs掺量、加载幅度、加载速度以及恒定荷载对电阻率变化的影响。研究表明:随着G-CNTs掺量的增加,电阻率呈先减小后稳定的变化趋势,在G-CNTs掺量由0.2wt%增加至1.6wt%时,电阻率下降51.8%;电阻率与温度呈负相关;G-CNTs掺量高于0.8wt%时可以显著提高水泥净浆的压敏性能,且电阻率变化率与应力应变有明显的对应关系,1.2wt%G-CNTs掺量下试件的应力灵敏系数和应变灵敏系数分别为2.3%/MPa和291;G-CNTs/水泥净浆电阻率变化率幅值随着加载幅度增大而相应增加,其电阻率变化率曲线在不同加载速度以及恒定荷载作用下均与应力-应变曲线一一对应,具有良好的压敏特性。     

Eco-friendly and degradable red phosphorus nanoparticles for rapid microbial sterilization under visible light

Pathogens pose a serious challenge to environmental sanitation and a threat to public health.The frequent use of chemicals for sterilization in recent years has not only caused secondary damage to the environment but also increased pathogen resistance to drugs,which further threatens public health.To address this issue,the use of non-chemical antibacterial means has become a new trend for environmental disinfection.In this study,we developed red phosphorus nanoparticles(RPNPs),a safe and degradable photosensitive material with good photocatalytic and photothermal properties.The red phosphorus nanoparticles were prepared using a template method and ultrasonication.Under the irradiation of simulated sunlight for 20 min,the RPNPs exhibited an efficiency of 99.98%in killing Staphylococcus aureus due to their excellent photocatalytic and photothermal abilities.Transmission electron microscopy and ultraviolet–visible spectroscopy revealed that the RPNPs exhibited degradability within eight weeks.Both the RPNPs and their degradation products were nontoxic to fibroblast cells.Therefore,such RPNPs are expected to be used as a new type of low-cost,efficient,degradable,biocompatible,and eco-friendly photosensitive material for environmental disinfection.