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排序方式: 共有1213条查询结果,搜索用时 109 毫秒
1.
Lopes Elio Jordan Kataria Shaolin Keshav Shashank Ikram Sumaiya Thaseen Ghalib Muhammad Rukunuddin Shankar Achyut Krichen Moez 《Wireless Networks》2022,28(7):3111-3125
Wireless Networks - In centralized video streaming platforms, the platform owner, rather than the content producer, controls most of the content uploaded on the centralized video... 相似文献
2.
Camila C. Lopes Wagner A. Pinheiro Daniel Navarro da Rocha José G. Neves Américo Bortolazzo Correr José R.M. Ferreira Rafael M. Barbosa Jefferson R.F. Soares Jheison L. Santos Marcelo H. Prado da Silva 《Ceramics International》2021,47(6):7653-7665
The repair of bone fractures is a clinical challenge for patients with impaired healing, such as osteoporosis. Currently, different strategies have been developed to design new biomaterials, enhancing their interactions with biological systems and conducting the cellular behavior in the desired direction to help fracture healing. In the present work, hydroxyapatite-graphene oxide (HA-GO) nanocomposites were produced and the morphological and physicochemical influences of the addition of 0.5 wt%, 1.0 wt% and 1.5 wt% of GO to HA were observed. FEG-SEM and TEM analyses of HA-GO nanocomposites showed HA nanoparticles adhered to the surface of the GO sheets, suggesting an effective method to form nanostructured graphene-based biomaterials. As confirmation, physicochemical analyses by Raman, FTIR and TGA demonstrated a strong affinity between HA and GO, according to the increase of concentration from 0.5 wt% to 1.5 wt% GO in the HA-GO nanocomposites. Also, in order to evaluate the HA-GO nanocomposites behavior under biological microenvironment, in vitro bioactivity and indirect cytotoxicity tests were performed. FEG-SEM analyses confirmed the positive results for the bioactivity properties of HA-GO nanocomposite and indirect cytotoxicity demonstrated that even with a decrease in the hDPSCs viability and proliferation, when increasing to 1.5 wt% of GO concentration, high level of cell viability was exhibited by HA-GO nanocomposites. These biological results suggested the 0.5 wt% HA-GO nanocomposite as a potential bioactive bone graft and a promising biomaterial for bone tissue regeneration, when compared to the pure HA. 相似文献
3.
P. Carrasqueira H. Rocha J. M. Dias T. Ventura B. C. Ferreira M. C. Lopes 《International Transactions in Operational Research》2023,30(1):206-223
Radiation therapy is a technology-driven cancer treatment modality that has experienced significant advances over the last decades, due to multidisciplinary contributions that include engineering and computing. Recent technological developments allow the use of noncoplanar volumetric modulated arc therapy (VMAT), one of the most recent photon treatment techniques, in clinical practice. In this work, an automated noncoplanar arc trajectory optimization framework designed in two modular phases is presented. First, a noncoplanar beam angle optimization algorithm is used to obtain a set of noncoplanar irradiation directions. Then, anchored in these directions, an optimization strategy is proposed to compute an optimal arc trajectory. The computational experiments considered a pool of twelve difficult head-and-neck tumor cases. It was possible to observe that, for some of these cases, the optimized noncoplanar arc trajectories led to significant treatment planning quality improvements, when compared with coplanar VMAT treatment plans. Although these experiments were done in a research environment treatment planning software (matRad), the conclusions can be of interest for a clinical setting: automated procedures can simplify the current treatment workflow, produce high-quality treatment plans, making better use of human resources and allowing for unbiased comparisons between different treatment techniques. 相似文献
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Engineering with Computers - This work presents a new efficient array-based algorithm for adaptive mesh refinement capable of interactively generating millions of triangles. The new refinement... 相似文献
6.
André Campaniço Dr. Marta P. Carrasco Dr. Mathew Njoroge Ronnett Seldon Prof. Kelly Chibale Dr. João Perdigão Prof. Isabel Portugal Prof. Digby F. Warner Prof. Rui Moreira Prof. Francisca Lopes 《ChemMedChem》2019,14(16):1537-1546
Herein we report the screening of a small library of aurones and their isosteric counterparts, azaaurones and N-acetylazaaurones, against Mycobacterium tuberculosis. Aurones were found to be inactive at 20 μm , whereas azaaurones and N-acetylazaaurones emerged as the most potent compounds, with nine derivatives displaying MIC99 values ranging from 0.4 to 2.0 μm . In addition, several N-acetylazaaurones were found to be active against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical M. tuberculosis isolates. The antimycobacterial mechanism of action of these compounds remains to be determined; however, a preliminary mechanistic study confirmed that they do not inhibit the mycobacterial cytochrome bc1 complex. Additionally, microsomal metabolic stability and metabolite identification studies revealed that N-acetylazaaurones are deacetylated to their azaaurone counterparts. Overall, these results demonstrate that azaaurones and their N-acetyl counterparts represent a new entry in the toolbox of chemotypes capable of inhibiting M. tuberculosis growth. 相似文献
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Margarida S. C. A. Brito Joana Matos Marina V. L. Torres Claudio P. Fonte Madalena M. Dias José Carlos B. Lopes Ricardo J. Santos 《American Institute of Chemical Engineers》2022,68(4):e17597
Product formulations for industrial processes are typically developed at laboratory scale. However, the mixing conditions are not easily mimicked in the laboratory. A rotational device is proposed in this study as a fast laboratory-scale formulation development, which enables mimicking the mixing conditions in the industrial process. The geometrical configurations of the rotational device are from rheometry devices (plate-plate and cone-plate). The main advantages of this method are the small amounts of raw materials and shorter testing times. This methodology is applied to an industrial case study, the reaction injection molding (RIM) process. The mixing length scales evolution in the rotational rheometer were matched to those in RIM machines. The main novelty of this study is the introduction of a protocol that bridges the processing conditions at laboratory using small amounts of raw materials to high throughput continuous flow reactors. 相似文献
9.
Laise Cedraz Pinto Tainá Pinheiro de Oliveira Rayane de Souza Nathane Brito Ferreira Santos Luis Fernandes Pereira Santos Andréa de Assis Santos Teodora Xavier dos Santos Carolaine Teixeira Santos Catarina de Jesus Nunes Isis Barbosa Costa Amanda Catariny de Oliveira Marly Silveira Santos Clícia Maria de Jesus Benevides Mariângela Vieira Lopes 《Journal of Food Processing and Preservation》2021,45(2):e15113
10.
Matheus Henrique Jantsch Viviane Martins Bernardes Juliana Sorraila Oliveira Daniela Ferreira Passos Guilherme Lopes Dornelles Alessandra Guedes Manzoni Fernanda Licker Cabral Jean Lucas Gutknecht da Silva Maria Rosa Chitolina Schetinger Daniela Bitencourt Rosa Leal 《Journal of Food Biochemistry》2021,45(4):e13636