Direct ink writing of vancomycin-loaded polycaprolactone/ polyethylene oxide/ hydroxyapatite 3D scaffolds

Novel inks were formulated by dissolving polycaprolactone (PCL), a hydrophobic polymer, in organic solvent systems; polyethylene oxide (PEO) was incorporated to extend the range of hydrophilicity of the system. Hydroxyapatite (HAp) with a weight ratio of 55–85% was added to the polymer-based solution to mimic the material composition of natural bone tissue. The direct ink writing (DIW) technique was applied to extrude the formulated inks to fabricate the predesigned tissue scaffold structures; the influence of HAp concentration was investigated. The results indicate that in comparison to other inks containing HAp (55%, 75%, and 85%w/w), the ink containing 65% w/w HAp had faster ink recovery behavior; the fabricated scaffold had a rougher surface as well as better mechanical properties and wettability. It is noted that the 65% w/w HAp concentration is similar to the inorganic composition of natural bone tissue. The elastic modulus values of PCL/PEO/HAp scaffolds were in the range of 4–12 MPa; the values were dependent on the HAp concentration. Furthermore, vancomycin as a model drug was successfully encapsulated in the PCL/PEO/HAp composite scaffold for drug release applications. This paper presents novel drug-loaded PCL/PEO/HAp inks for 3D scaffold fabrication using the DIW printing technique for potential bone scaffold applications.     

Ternary type BaY2ZnO5: Eu3+ deep-red phosphor for possible latent fingerprint,security ink and WLED applications

Pc-WLEDs are considered to play a spectacular role in future generation light sources in view of their outstanding energy efficiency. In this regard, Eu³⁺ activated BaY₂ZnO₅ phosphor was prepared and investigated by XRD, PL and SEM analyses. Rietveld refinement analysis was carried out to confirm the structure of the synthesized phosphor. The prepared phosphor shows an intense red emission around 627 nm under excitation by near UV light. The ⁵D₀-⁷F₂ transition intensity of the prepared phosphor is three times higher compared to the commercial (Y,Gd)BO₃:Eu³⁺ red phosphor. The CIE colour coordinates of BaY₂ZnO₅:Eu³⁺ (9mol%) phosphor corresponds to be (0.6169, 0.3742) and it has a high 97.9 % colour purity. The obtained results reveal the utility of BaY₂ZnO₅:Eu³⁺ phosphor as an efficient red component in WLEDs, anti-counterfeiting and fingerprint detection applications.     

The impact of the thermal treatment during ink preparation on the ionomer-supported catalyst interactions in the catalyst layers

Catalyst slurries (inks) were prepared with and without thermal treatment to determine the support/ionomer structures and interactions in the catalyst layer (CL) which impact on membrane electrode performance and durability. The thermal treatment of the ink has a nominal effect on the ionomer/support structure in which the carbon support is non-graphitised. The agglomerate/aggregate structures have a high degree of support/ionomer interface and sufficient macroporosity for water movement in the CL. This improves the membrane electrode assembly (MEA) performance, but also accelerates electrochemical carbon degradation. Thermal treatment of graphitised support-containing inks resulted in increased performance facilitated by a larger support/ionomer interface. Without thermal treatment, the more hydrophobic support would form aggregate structures in which water contact was restricted, limiting proton transfer, isolating catalyst, decreasing performance. The water limited access, would however, prolong stability during accelerates carbon degradation. The electrochemical properties were studied using full and half MEA cells.     

Preparation of P(St-NMA) microsphere inks and their application in photonic crystal patterns with brilliant structural colors

Patterned photonic crystals with structural colors on textile substrates have attracted a special attention due to the great advantages in application, which currently become a research hot-spot. This study utilized an ink-jet printing technology to prepare high-quality photonic crystal patterns with structural colors on polyester substrates. The self-assembly temperature of poly(styrene-N-methylol acrylamide) (P(St-NMA)) microspheres set to construct photonic crystals were deeply optimized. Moreover, the structural colors of prepared photonic crystal patterns were characterized and evaluated. When the mass fraction of P(St-NMA) microspheres was 1.0 wt.%, the pH value ranged from 5 to 7, and the surface tension was in the range of 63.79 to 71.20 mN/m, inks could present the best print performance. At 60 °C, prepared P(St-NMA) microsphere inks were good for printing to obtain patterned photonic crystals with regular arrangement and beautiful structural colors. Specifically, photonic crystals with different colors could be constructed by regulating the diameter of microspheres in inks, and prepared structural colors exhibited distinct iridescent phenomenon. The present results could provide a theoretical basis for the industrial realization of patterned photonic crystals by ink-jet printing technology.     

钢铁生产的水能关系分析

从钢铁生产过程中水资源使用时的能耗角度研究了钢铁联合企业的水能关系，提出了水能强度的概念来评价企业生产过程中水资源利用的节能水平，建立了钢铁企业的水能关系模型。以中国某大型钢铁联合企业为例，计算并分析了该企业的水能关系。该企业总的水能量为55 709 kW·h/h，重复用水水能量占整个钢铁企业全部水能量的82%，补水水能量占16%，排水水能量占1%；各工序中热轧工序占比最大，其次是炼铁、炼钢工序，冷轧、烧结和炼焦工序较低。该企业的吨钢水能强度为0.208 kW·h/m3，炼铁工序的水能强度最高，热轧、炼钢工序次之，烧结、冷轧和炼焦工序较低。最后，从钢铁生产过程水资源利用的角度得到节能的方向及措施。     

Formulating Pantone colors by unused base inks,formulation software,and a spectrophotometer

Unused base inks that are not going to be used for printing production are considered to be hazardous materials. Their disposal is expensive, and strict environmental regulations should be followed for their disposal. As an alternative, this article describes how spectral data of unused base inks can be gathered and mixed to generate new colors to incorporate them back to print production for small‐volume jobs. In this study, 30 different Pantone colors were selected as target colors. The CIE L*a*b* spectral data of Pantone colors and unused base inks were gathered via a spectrophotometer. A commercial formulation software, based on multiflux theory and CIE L*a*b* color space, was used to formulate ink recipes that contained the base inks. To quantify the performance of ink recipes, they were mixed and printed using an offset printability tester. The CIELAB ΔE*_ab metric, developed by CIE, was used to detect the visual differences between the target Pantone Color and printed colors.     

基于时间延迟的多类型维修与经济生产批量联合优化研究

针对目前未能较好的综合考虑多维修类型与经济生产批量联合优化的问题，首先考虑多类型维修关系，基于时间延迟理论求出故障和缺陷次数的表达式；其次，在此基础上，综合考虑生产费用和维修费用的基础上，构建了多类型维修和经济生产批量联合优化模型，以单位时间内总费用最小为优化目标，获得最优检查间隔期和经济生产批量；最后，通过算例分析验证了模型的有效性，说明了第一类缺陷检查次数的多少对费用和经济生产批量影响不大。     

氮酮与薄荷醇联用对5-氟尿嘧啶的促透作用

目的：以5-氟尿嘧啶（5-FU）为模型药物，对氮酮和薄荷醇的促透特性进行比较，并探讨两种促透剂合用时的促透效果。方法：在离体透皮实验装置上进行透皮试验，由浓度计算累积透过量，运用倍量法对氮酮与薄荷醇联用的效果进行评价。结果： 浓度为0.25%、0.50%、1.00%、2.00%的氮酮对5-FU均有促透作用，与空白对照组相比，差异具有统计学意义（P<0.01）；浓度为0.25%、0.50%、1.00%、2.00%的薄荷醇对5-FU也有明显的促透作用，与空白对照相比，差异具有统计学意义（P<0.01）；用倍量法对两种药物联用的作用进行评价分析时，二者联用未显示有协同作用。结论：氮酮和薄荷醇对（5-FU）均有促透作用，但二者以相同浓度合用时，未有明显的协同作用。     

机械密封腔流场内粒子对密封腔壁面及波纹管冲蚀分析

为研究机械密封腔内混有固体颗粒的流体,在复杂工况下对密封腔壁面及波纹管表面冲蚀的影响,以CFD理论及方法,采用k-ε湍流模型和离散项DPM模型,对固液混合流场进行模拟分析,获得密封腔内流体中介质作用下密封腔壁面及波纹管外表面的压力场分布,分析不同工作状态下固体颗粒作用下密封腔内壁和波纹管外表面的冲蚀区域分布、固体颗粒在流场中的运动轨迹,以及机械密封工作过程中流场内固体颗粒的逃逸量、运动状态的变化。结果表明:粒子主要受颗粒阻力、浮重力、压力梯度力及波纹管和密封腔表面反作用力的影响;在旋转流场中,粒子作与旋转方向一致的螺旋方式前进;无转速时,冲蚀多发生在靠近入口处的波纹管外表面,旋转流场中,冲蚀多发生在密封腔靠后位置的壁面;随着转速增加,粒子逃逸率下降。研究结论为机械密封腔的设计布局及机械密封装置的优化提供理论依据。     

一种模拟量模块的应用

模拟量模块采用RS485通讯网路,将分散的现场数据点的模拟量经AD变换传输到主机或由PC控制远程主站点。模拟量模块具有计量数据采集、测量数据采集、设备开关状态采集和对外逻辑控制等多项功能,主要用作各种测控终端的数据采集、控制和显示设备,适用于各行业的自动化、信息化系统。本文介绍了一种模拟量模块的应用。